5I42
Structure of HIV-1 Reverse Transcriptase in complex with a DNA aptamer, AZTTP, and CA(2+) ion
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003676 | molecular_function | nucleic acid binding |
A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
B | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
B | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
C | 0003676 | molecular_function | nucleic acid binding |
C | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
C | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
C | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
D | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
D | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue CA A 601 |
Chain | Residue |
A | ASP110 |
A | VAL111 |
A | ASP185 |
A | AZT602 |
site_id | AC2 |
Number of Residues | 15 |
Details | binding site for residue AZT A 602 |
Chain | Residue |
A | ASP113 |
A | ALA114 |
A | TYR115 |
A | PHE116 |
A | GLN151 |
A | ASP185 |
A | LYS220 |
A | CA601 |
E | DA1 |
E | DG34 |
A | LYS65 |
A | ARG72 |
A | ASP110 |
A | VAL111 |
A | GLY112 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue CA C 601 |
Chain | Residue |
C | ASP110 |
C | VAL111 |
C | ASP185 |
C | AZT602 |
site_id | AC4 |
Number of Residues | 15 |
Details | binding site for residue AZT C 602 |
Chain | Residue |
C | LYS65 |
C | ARG72 |
C | ASP110 |
C | VAL111 |
C | GLY112 |
C | ASP113 |
C | ALA114 |
C | TYR115 |
C | PHE116 |
C | GLN151 |
C | ASP185 |
C | CA601 |
F | DA1 |
F | DC2 |
F | DG34 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | BINDING: |
Chain | Residue | Details |
B | ASP110 | |
B | ASP185 | |
B | ASP186 | |
D | ASP110 | |
D | ASP185 | |
D | ASP186 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | SITE: Essential for RT p66/p51 heterodimerization |
Chain | Residue | Details |
B | TRP401 | |
B | TRP414 | |
D | TRP401 | |
D | TRP414 | |
C | ASP443 | |
C | GLU478 | |
C | ASP498 | |
C | ASP549 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | SITE: Essential for RT p66/p51 heterodimerization |
Chain | Residue | Details |
A | TRP401 | |
A | TRP414 | |
C | TRP401 | |
C | TRP414 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | SITE: Cleavage; by viral protease; partial |
Chain | Residue | Details |
A | PHE440 | |
C | PHE440 |