5HKX

Crystal Structure of c-Cbl TKBD-RING domains (Y371E mutant) Refined to 1.85 A Resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001784	molecular_function	phosphotyrosine residue binding
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005509	molecular_function	calcium ion binding
A	0007166	biological_process	cell surface receptor signaling pathway
A	0023051	biological_process	regulation of signaling
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue EDO A 501

Chain	Residue
A	LEU328
A	ASN346
A	PRO347
A	ASP348
A	LEU349
A	HOH635

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 502

Chain	Residue
A	CYS419
A	CYS396
A	HIS398
A	CYS416

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 503

Chain	Residue
A	CYS381
A	CYS384
A	CYS401
A	CYS404

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site_id	AC4
Number of Residues	6
Details	binding site for residue NA A 504

Chain	Residue
A	ASP229
A	THR231
A	ASN233
A	TYR235
A	GLU240
A	HOH667

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Functional Information from PROSITE/UniProt

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CgHlMCtsCL

Chain	Residue	Details
A	CYS396-LEU405

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	39
Details	ZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175

Chain	Residue	Details
A	CYS381-ARG420

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL

Chain	Residue	Details
A	THR231
A	ASN233
A	TYR235
A	GLU240
A	ASP229

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ARG294

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497

Chain	Residue	Details
A	GLU371

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