5HKX
Crystal Structure of c-Cbl TKBD-RING domains (Y371E mutant) Refined to 1.85 A Resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | E3 ubiquitin-protein ligase CBL | polymer | 392 | 45166.9 | 1 | UniProt (P22681) Pfam (PF02262) Pfam (PF02761) Pfam (PF02762) Pfam (PF00097) | Homo sapiens (Human) | Casitas B-lineage lymphoma proto-oncogene,Proto-oncogene c-Cbl,RING finger protein 55,Signal transduction protein CBL |
| 2 | B (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 3 | C, D (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | F (A) | water | water | 18.0 | 235 | Chemie (HOH) |
Sequence modifications
A: 47 - 435 (UniProt: P22681)
| PDB | External Database | Details |
|---|---|---|
| Ser 44 | - | expression tag |
| Asn 45 | - | expression tag |
| Ala 46 | - | expression tag |
| Glu 371 | Tyr 371 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45166.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 215.9 | |
| All* | Total formula weight | 45382.8 |
