5HKX
Crystal Structure of c-Cbl TKBD-RING domains (Y371E mutant) Refined to 1.85 A Resolution
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | E3 ubiquitin-protein ligase CBL | polymer | 392 | 45166.9 | 1 | UniProt (P22681) Pfam (PF02262) Pfam (PF02761) Pfam (PF02762) Pfam (PF00097) In PDB | Homo sapiens (Human) | Casitas B-lineage lymphoma proto-oncogene,Proto-oncogene c-Cbl,RING finger protein 55,Signal transduction protein CBL |
2 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
3 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
4 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
5 | water | water | 18.0 | 235 | Chemie (HOH) |
Sequence modifications
A: 47 - 435 (UniProt: P22681)
PDB | External Database | Details |
---|---|---|
Ser 44 | - | expression tag |
Asn 45 | - | expression tag |
Ala 46 | - | expression tag |
Glu 371 | Tyr 371 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 45166.9 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 215.9 | |
All* | Total formula weight | 45382.8 |