5GUT
The crystal structure of mouse DNMT1 (731-1602) mutant - N1248A
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue SAH A 1701 |
| Chain | Residue |
| A | PHE1148 |
| A | TRP1173 |
| A | GLU1192 |
| A | ASP1193 |
| A | CYS1194 |
| A | GLY1226 |
| A | LEU1250 |
| A | ASN1580 |
| A | ALA1581 |
| A | VAL1582 |
| A | HOH1906 |
| A | SER1149 |
| A | HOH1941 |
| A | HOH1977 |
| A | HOH1982 |
| A | HOH2001 |
| A | HOH2071 |
| A | GLY1150 |
| A | CYS1151 |
| A | GLY1152 |
| A | GLY1153 |
| A | LEU1154 |
| A | GLU1171 |
| A | MET1172 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1702 |
| Chain | Residue |
| A | HIS796 |
| A | CYS823 |
| A | CYS897 |
| A | CYS900 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1703 |
| Chain | Residue |
| A | CYS1479 |
| A | CYS1481 |
| A | CYS1487 |
| A | HIS1504 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 1704 |
| Chain | Residue |
| A | GLN1303 |
| A | THR1312 |
| A | ARG1313 |
| A | ARG1314 |
| A | THR1527 |
| A | HOH1845 |
| A | HOH2041 |
| A | HOH2122 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 1705 |
| Chain | Residue |
| A | GLN1409 |
| A | ARG1413 |
| A | SER1564 |
| A | HOH1858 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1706 |
| Chain | Residue |
| A | GLN1446 |
| A | HIS1456 |
| A | LYS1457 |
| A | HOH1808 |
| A | HOH1856 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1707 |
| Chain | Residue |
| A | ASN953 |
| A | ASP1049 |
| A | GLU1050 |
| A | GLU1051 |
| A | HOH2097 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 1708 |
| Chain | Residue |
| A | ARG1181 |
| A | THR1187 |
| A | VAL1189 |
| A | GLN1212 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1709 |
| Chain | Residue |
| A | ASN1239 |
| A | ARG1241 |
| A | THR1242 |
| A | LYS1245 |
| A | ARG1278 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 1710 |
| Chain | Residue |
| A | HIS1031 |
| A | ARG1032 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1711 |
| Chain | Residue |
| A | PHE1494 |
| A | SER1495 |
| A | HOH1947 |
| A | HOH2048 |
| A | HOH2059 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 1712 |
| Chain | Residue |
| A | ALA949 |
| A | PHE950 |
| A | THR951 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1713 |
| Chain | Residue |
| A | GLN875 |
| A | GLU876 |
| A | ARG902 |
| A | LYS1095 |
| A | HOH1880 |
Functional Information from PROSITE/UniProt
| site_id | PS00094 |
| Number of Residues | 13 |
| Details | C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. EmLcgGpPCqGFS |
| Chain | Residue | Details |
| A | GLU1221-SER1233 |
| site_id | PS00095 |
| Number of Residues | 19 |
| Details | C5_MTASE_2 C-5 cytosine-specific DNA methylases C-terminal signature. RqvGNAVpPpLakaIgleI |
| Chain | Residue | Details |
| A | ARG1576-ILE1594 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"17576694","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21163962","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3PT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DA4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21163962","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3PT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DA4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21163962","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3PT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PT9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P26358","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P26358","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
