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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5GNK

Crystal structure of EGFR 696-988 T790M in complex with LXX-6-34

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue 80U A 1001

Chain	Residue
A	LEU718
A	CYS797
A	ARG841
A	LEU844
A	THR854
A	ASP855
A	EDO1026
A	EDO1027
A	HOH1205
A	ALA743
A	LYS745
A	MET766
A	CYS775
A	LEU788
A	MET790
A	GLN791
A	MET793

site_id	AC2
Number of Residues	5
Details	binding site for residue NO3 A 1002

Chain	Residue
A	LYS713
A	LYS739
A	THR847
A	PRO848
A	GLN849

site_id	AC3
Number of Residues	7
Details	binding site for residue NO3 A 1003

Chain	Residue
A	GLU804
A	HIS805
A	LYS806
A	ASP807
A	ASN808
A	HOH1112
A	HOH1170

site_id	AC4
Number of Residues	6
Details	binding site for residue NO3 A 1004

Chain	Residue
A	ASN816
A	VAL819
A	GLN820
A	LYS823
A	EDO1023
A	HOH1138

site_id	AC5
Number of Residues	10
Details	binding site for residue NO3 A 1005

Chain	Residue
A	GLY721
A	ALA722
A	PHE723
A	GLY724
A	LYS745
A	ARG841
A	ASN842
A	ASP855
A	EDO1026
A	HOH1104

site_id	AC6
Number of Residues	3
Details	binding site for residue NO3 A 1006

Chain	Residue
A	SER912
A	PRO937
A	NO31031

site_id	AC7
Number of Residues	7
Details	binding site for residue NO3 A 1007

Chain	Residue
A	ILE715
A	LYS728
A	PHE795
A	TYR801
A	GLU804
A	HIS805
A	HOH1103

site_id	AC8
Number of Residues	4
Details	binding site for residue NO3 A 1008

Chain	Residue
A	LYS714
A	ILE715
A	TYR727
A	HOH1254

site_id	AC9
Number of Residues	5
Details	binding site for residue NO3 A 1009

Chain	Residue
A	PRO877
A	ILE878
A	LYS879
A	TRP880
A	ALA920

site_id	AD1
Number of Residues	4
Details	binding site for residue NO3 A 1010

Chain	Residue
A	GLU884
A	ILE953
A	ASP954
A	ALA955

site_id	AD2
Number of Residues	4
Details	binding site for residue EDO A 1011

Chain	Residue
A	ARG705
A	ARG776
A	LEU778
A	HOH1117

site_id	AD3
Number of Residues	7
Details	binding site for residue EDO A 1012

Chain	Residue
A	GLU709
A	PHE712
A	LYS714
A	GLN787
A	HOH1122
A	HOH1198
A	HOH1258

site_id	AD4
Number of Residues	3
Details	binding site for residue EDO A 1013

Chain	Residue
A	GLY724
A	THR725
A	GLU746

site_id	AD5
Number of Residues	4
Details	binding site for residue EDO A 1014

Chain	Residue
A	ASN771
A	LYS823
A	EDO1015
A	HOH1115

site_id	AD6
Number of Residues	4
Details	binding site for residue EDO A 1015

Chain	Residue
A	PRO753
A	ILE965
A	EDO1014
A	HOH1131

site_id	AD7
Number of Residues	4
Details	binding site for residue CL A 1016

Chain	Residue
A	CYS775
A	ARG776
A	GLN791
A	LYS852

site_id	AD8
Number of Residues	4
Details	binding site for residue EDO A 1017

Chain	Residue
A	LEU883
A	GLU884
A	HIS888
A	HOH1147

site_id	AD9
Number of Residues	2
Details	binding site for residue EDO A 1018

Chain	Residue
A	HIS893
A	THR892

site_id	AE1
Number of Residues	2
Details	binding site for residue EDO A 1019

Chain	Residue
A	ILE981
A	GLN982

site_id	AE2
Number of Residues	5
Details	binding site for residue EDO A 1020

Chain	Residue
A	ASP956
A	ARG958
A	LYS960
A	GLU963
A	HOH1155

site_id	AE3
Number of Residues	3
Details	binding site for residue EDO A 1021

Chain	Residue
A	ARG889
A	LYS970
A	TYR978

site_id	AE4
Number of Residues	2
Details	binding site for residue EDO A 1022

Chain	Residue
A	GLU762
A	HOH1107

site_id	AE5
Number of Residues	5
Details	binding site for residue EDO A 1023

Chain	Residue
A	GLN820
A	GLN849
A	NO31004
A	HOH1239
A	HOH1263

site_id	AE6
Number of Residues	2
Details	binding site for residue EDO A 1024

Chain	Residue
A	GLY911
A	HOH1124

site_id	AE7
Number of Residues	3
Details	binding site for residue EDO A 1025

Chain	Residue
A	THR783
A	GLU928
A	HOH1211

site_id	AE8
Number of Residues	9
Details	binding site for residue EDO A 1026

Chain	Residue
A	SER720
A	GLY721
A	VAL726
A	ARG841
A	80U1001
A	NO31005
A	EDO1027
A	HOH1113
A	HOH1205

site_id	AE9
Number of Residues	7
Details	binding site for residue EDO A 1027

Chain	Residue
A	SER720
A	80U1001
A	EDO1026
A	HOH1132
A	HOH1171
A	HOH1218
A	HOH1262

site_id	AF1
Number of Residues	3
Details	binding site for residue CL A 1028

Chain	Residue
A	LYS846
A	HIS850
A	LYS852

site_id	AF2
Number of Residues	7
Details	binding site for residue NO3 A 1029

Chain	Residue
A	TYR801
A	HIS805
A	ASN808
A	ILE809
A	TYR813
A	PRO848
A	HOH1229

site_id	AF3
Number of Residues	7
Details	binding site for residue EDO A 1030

Chain	Residue
A	ASP837
A	ALA839
A	ARG841
A	TRP880
A	HOH1192
A	HOH1216
A	HOH1232

site_id	AF4
Number of Residues	8
Details	binding site for residue NO3 A 1031

Chain	Residue
A	TRP905
A	LYS913
A	TYR915
A	ASP916
A	LEU933
A	PRO934
A	NO31006
A	HOH1164

site_id	AF5
Number of Residues	4
Details	binding site for residue EDO A 1032

Chain	Residue
A	LYS716
A	LEU718
A	LYS728
A	HOH1114

site_id	AF6
Number of Residues	5
Details	binding site for residue EDO A 1033

Chain	Residue
A	LEU782
A	ARG932
A	VAL948
A	TRP951
A	MET952

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	28
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGAFGTVYkGlwipegekvkip......VAIK

Chain	Residue	Details
A	LEU718-LYS745

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LVHrDLAARNVLV

Chain	Residue	Details
A	LEU833-VAL845

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU00159, ECO:0000255\|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP837

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:19563760, ECO:0007744\|PDB:2GS7, ECO:0007744\|PDB:3GT8, ECO:0007744\|PDB:4ZSE, ECO:0007744\|PDB:5CNN, ECO:0007744\|PDB:5CNO, ECO:0007744\|PDB:5D41

Chain	Residue	Details
A	LEU718

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:17349580, ECO:0000269\|PubMed:19563760, ECO:0007744\|PDB:2EB3, ECO:0007744\|PDB:2GS7, ECO:0007744\|PDB:2ITN, ECO:0007744\|PDB:3GT8, ECO:0007744\|PDB:3VJN, ECO:0007744\|PDB:3VJO, ECO:0007744\|PDB:4RIW, ECO:0007744\|PDB:4RIY, ECO:0007744\|PDB:4ZSE, ECO:0007744\|PDB:5CNN, ECO:0007744\|PDB:5CNO, ECO:0007744\|PDB:5D41

Chain	Residue	Details
A	LYS745

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:17349580, ECO:0000269\|PubMed:19563760, ECO:0007744\|PDB:2EB3, ECO:0007744\|PDB:2GS7, ECO:0007744\|PDB:2ITN, ECO:0007744\|PDB:2ITV, ECO:0007744\|PDB:2ITX, ECO:0007744\|PDB:3GT8, ECO:0007744\|PDB:3VJN, ECO:0007744\|PDB:3VJO, ECO:0007744\|PDB:4RIW, ECO:0007744\|PDB:4RIX, ECO:0007744\|PDB:4RIY, ECO:0007744\|PDB:4ZSE, ECO:0007744\|PDB:5CNN, ECO:0007744\|PDB:5CNO, ECO:0007744\|PDB:5D41

Chain	Residue	Details
A	MET790

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:17349580, ECO:0000269\|PubMed:19563760, ECO:0007744\|PDB:2EB3, ECO:0007744\|PDB:2GS7, ECO:0007744\|PDB:2ITN, ECO:0007744\|PDB:2ITV, ECO:0007744\|PDB:2ITX, ECO:0007744\|PDB:3GT8, ECO:0007744\|PDB:3VJN, ECO:0007744\|PDB:4RIW, ECO:0007744\|PDB:4RIX, ECO:0007744\|PDB:4RIY, ECO:0007744\|PDB:4ZSE, ECO:0007744\|PDB:5CNN, ECO:0007744\|PDB:5CNO, ECO:0007744\|PDB:5D41

Chain	Residue	Details
A	ASP855

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000269\|PubMed:29192674

Chain	Residue	Details
A	LYS745

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000269\|PubMed:23774213

Chain	Residue	Details
A	TYR869

site_id	SWS_FT_FI8
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16543144, ECO:0000269\|PubMed:33996800

Chain	Residue	Details
A	LYS716
A	LYS737
A	LYS754
A	LYS867

site_id	SWS_FT_FI9
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16543144

Chain	Residue	Details
A	LYS929
A	LYS970

site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:33996800

Chain	Residue	Details
A	LYS757
A	LYS960

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PDB entries from 2024-07-24

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