5GNK
Crystal structure of EGFR 696-988 T790M in complex with LXX-6-34
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 297 | 33777.5 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | 1-[(3R)-3-[4-azanyl-3-[3-chloranyl-4-[(1-methylimidazol-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | non-polymer | 493.0 | 1 | Chemie (80U) | |||
| 3 | C, D, DA, E, F... (A) | NITRATE ION | non-polymer | 62.0 | 11 | Chemie (NO3) | |||
| 4 | AA, BA, EA, GA, HA... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 19 | Chemie (EDO) | |||
| 5 | CA, Q (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | IA (A) | water | water | 18.0 | 239 | Chemie (HOH) |
Sequence modifications
A: 696 - 988 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 692 | - | expression tag |
| Ala 693 | - | expression tag |
| Met 694 | - | expression tag |
| Gly 695 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33777.5 | |
| Non-Polymers* | Number of molecules | 33 |
| Total formula weight | 2425.2 | |
| All* | Total formula weight | 36202.7 |
