Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5F9F

Crystal structure of RIG-I helicase-RD in complex with 24-mer blunt-end hairpin RNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0005524	molecular_function	ATP binding
C	0003676	molecular_function	nucleic acid binding
C	0005524	molecular_function	ATP binding
E	0003676	molecular_function	nucleic acid binding
E	0005524	molecular_function	ATP binding
G	0003676	molecular_function	nucleic acid binding
G	0005524	molecular_function	ATP binding
I	0003676	molecular_function	nucleic acid binding
I	0005524	molecular_function	ATP binding
K	0003676	molecular_function	nucleic acid binding
K	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1001

Chain	Residue
A	CYS810
A	CYS813
A	CYS864
A	CYS869

site_id	AC2
Number of Residues	1
Details	binding site for residue MG A 1002

Chain	Residue
A	LYS723

site_id	AC3
Number of Residues	6
Details	binding site for residue ETF A 1003

Chain	Residue
A	LEU408
A	THR409
A	ILE262
A	ALA264
A	CYS268
A	LYS270

site_id	AC4
Number of Residues	6
Details	binding site for residue BU3 A 1004

Chain	Residue
A	GLU510
A	ARG546
A	ASP550
A	TYR566
A	THR636
B	A19

site_id	AC5
Number of Residues	4
Details	binding site for residue BU3 A 1005

Chain	Residue
A	GLY269
A	LYS270
A	THR271
A	PHE272

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN C 1001

Chain	Residue
C	CYS810
C	CYS813
C	CYS864
C	CYS869

site_id	AC7
Number of Residues	4
Details	binding site for residue BU3 C 1003

Chain	Residue
C	LYS666
C	THR667
C	ASN668
C	LYS888

site_id	AC8
Number of Residues	9
Details	binding site for residue BU3 C 1004

Chain	Residue
A	ARG320
A	GLN336
A	ILE337
A	ASN340
A	ASN341
C	ARG320
C	ILE337
C	ASN340
C	ASN341

site_id	AC9
Number of Residues	4
Details	binding site for residue BU3 C 1005

Chain	Residue
C	ASN376
C	ALA700
D	A5
D	U22

site_id	AD1
Number of Residues	6
Details	binding site for residue BU3 C 1006

Chain	Residue
C	ILE262
C	ALA264
C	CYS268
C	LYS270
C	LEU408
C	THR409

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN E 1001

Chain	Residue
E	CYS810
E	CYS813
E	CYS864
E	CYS869

site_id	AD3
Number of Residues	5
Details	binding site for residue ETF E 1002

Chain	Residue
E	LYS666
E	ASN668
E	GLN669
E	ASP872
E	LYS888

site_id	AD4
Number of Residues	8
Details	binding site for residue BU3 E 1003

Chain	Residue
E	LEU250
E	ILE262
E	ALA264
E	CYS268
E	LYS270
E	VAL273
E	LEU408
E	THR409

site_id	AD5
Number of Residues	8
Details	binding site for residue BU3 E 1004

Chain	Residue
E	LEU714
E	TYR717
E	GLY719
E	ASN720
E	LYS723
E	MET724
E	THR727
E	GLU751

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN G 1001

Chain	Residue
G	CYS810
G	CYS813
G	CYS864
G	CYS869

site_id	AD7
Number of Residues	8
Details	binding site for residue ETF G 1002

Chain	Residue
G	ARG320
G	ILE337
G	ASN340
G	ASN341
K	GLN336
K	ILE337
K	ASN340
K	ASN341

site_id	AD8
Number of Residues	7
Details	binding site for residue BU3 G 1003

Chain	Residue
G	ILE262
G	ALA264
G	PRO265
G	CYS268
G	LYS270
G	THR409
G	GLU702

site_id	AD9
Number of Residues	5
Details	binding site for residue BU3 G 1004

Chain	Residue
G	ALA329
G	GLU330
G	ILE350
G	ASN353
G	ASN354

site_id	AE1
Number of Residues	6
Details	binding site for residue BU3 G 1005

Chain	Residue
G	GLY719
G	LYS723
G	THR727
G	GLU751
G	LEU714
G	TYR717

site_id	AE2
Number of Residues	4
Details	binding site for residue ZN I 1001

Chain	Residue
I	CYS810
I	CYS813
I	CYS864
I	CYS869

site_id	AE3
Number of Residues	1
Details	binding site for residue MG I 1003

Chain	Residue
I	LYS723

site_id	AE4
Number of Residues	6
Details	binding site for residue BU3 I 1004

Chain	Residue
I	ILE262
I	ALA264
I	CYS268
I	LYS270
I	LEU408
I	THR409

site_id	AE5
Number of Residues	4
Details	binding site for residue ZN K 1001

Chain	Residue
K	CYS810
K	CYS813
K	CYS864
K	CYS869

site_id	AE6
Number of Residues	1
Details	binding site for residue MG K 1002

Chain	Residue
K	LYS723

site_id	AE7
Number of Residues	5
Details	binding site for residue ETF K 1003

Chain	Residue
K	PRO456
K	LYS458
K	THR727
K	ARG728
K	CYS738

site_id	AE8
Number of Residues	6
Details	binding site for residue BU3 K 1004

Chain	Residue
K	ILE262
K	ALA264
K	CYS268
K	LYS270
K	LEU408
K	THR409

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1074
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	996
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	18
Details	Motif: {"description":"DECH box"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	42
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01125","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	6
Details	Modified residue: {"description":"(Microbial infection) Deamidated asparagine; by herpes simplex virus 1/HHV-1 UL37","evidences":[{"source":"PubMed","id":"27866900","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine; by CK2","evidences":[{"source":"PubMed","id":"21068236","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine; by CK2","evidences":[{"source":"PubMed","id":"21068236","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"26746851","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q6Q899","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)