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5EYA

TRIM25 RING domain in complex with Ubc13-Ub conjugate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000151cellular_componentubiquitin ligase complex
A0000166molecular_functionnucleotide binding
A0000209biological_processprotein polyubiquitination
A0000724biological_processdouble-strand break repair via homologous recombination
A0000729biological_processDNA double-strand break processing
A0001650cellular_componentfibrillar center
A0003723molecular_functionRNA binding
A0004842molecular_functionubiquitin-protein transferase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006281biological_processDNA repair
A0006282biological_processregulation of DNA repair
A0006301biological_processDNA damage tolerance
A0006513biological_processprotein monoubiquitination
A0006974biological_processDNA damage response
A0016567biological_processprotein ubiquitination
A0016740molecular_functiontransferase activity
A0031371cellular_componentubiquitin conjugating enzyme complex
A0031372cellular_componentUBC13-MMS2 complex
A0031625molecular_functionubiquitin protein ligase binding
A0032991cellular_componentprotein-containing complex
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043130molecular_functionubiquitin binding
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0045739biological_processpositive regulation of DNA repair
A0050852biological_processT cell receptor signaling pathway
A0061631molecular_functionubiquitin conjugating enzyme activity
A0070062cellular_componentextracellular exosome
A0070534biological_processprotein K63-linked ubiquitination
A0097027molecular_functionubiquitin-protein transferase activator activity
A0140374biological_processantiviral innate immune response
A1902523biological_processpositive regulation of protein K63-linked ubiquitination
A1902533biological_processpositive regulation of intracellular signal transduction
A1904262biological_processnegative regulation of TORC1 signaling
A2000781biological_processpositive regulation of double-strand break repair
B0000151cellular_componentubiquitin ligase complex
B0000166molecular_functionnucleotide binding
B0000209biological_processprotein polyubiquitination
B0000724biological_processdouble-strand break repair via homologous recombination
B0000729biological_processDNA double-strand break processing
B0001650cellular_componentfibrillar center
B0003723molecular_functionRNA binding
B0004842molecular_functionubiquitin-protein transferase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006281biological_processDNA repair
B0006282biological_processregulation of DNA repair
B0006301biological_processDNA damage tolerance
B0006513biological_processprotein monoubiquitination
B0006974biological_processDNA damage response
B0016567biological_processprotein ubiquitination
B0016740molecular_functiontransferase activity
B0031371cellular_componentubiquitin conjugating enzyme complex
B0031372cellular_componentUBC13-MMS2 complex
B0031625molecular_functionubiquitin protein ligase binding
B0032991cellular_componentprotein-containing complex
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043130molecular_functionubiquitin binding
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0045739biological_processpositive regulation of DNA repair
B0050852biological_processT cell receptor signaling pathway
B0061631molecular_functionubiquitin conjugating enzyme activity
B0070062cellular_componentextracellular exosome
B0070534biological_processprotein K63-linked ubiquitination
B0097027molecular_functionubiquitin-protein transferase activator activity
B0140374biological_processantiviral innate immune response
B1902523biological_processpositive regulation of protein K63-linked ubiquitination
B1902533biological_processpositive regulation of intracellular signal transduction
B1904262biological_processnegative regulation of TORC1 signaling
B2000781biological_processpositive regulation of double-strand break repair
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN F 101
ChainResidue
FCYS28
FHIS30
FCYS50
FCYS53

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN F 102
ChainResidue
FCYS13
FCYS16
FCYS33
FCYS36

site_idAC3
Number of Residues4
Detailsbinding site for residue ZN G 101
ChainResidue
GHIS30
GCYS50
GCYS53
GCYS28

site_idAC4
Number of Residues4
Detailsbinding site for residue ZN G 102
ChainResidue
GCYS13
GCYS16
GCYS33
GCYS36

site_idAC5
Number of Residues18
Detailsbinding site for Di-peptide GLY C 76 and LYS B 87
ChainResidue
BPHE47
BILE75
BHIS77
BASN79
BILE86
BLEU88
BASP119
BPRO120
BLEU121
BGLN128
BTRP129
BALA136
BTHR139
BTRP143
BHOH212
BHOH224
CARG74
CGLY75

Functional Information from PROSITE/UniProt
site_idPS00299
Number of Residues26
DetailsUBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD
ChainResidueDetails
CLYS27-ASP52

site_idPS00518
Number of Residues10
DetailsZF_RING_1 Zinc finger RING-type signature. CgHnFCgsCL
ChainResidueDetails
FCYS28-LEU37

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues292
DetailsDomain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsActive site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)","evidences":[{"source":"PubMed","id":"16112642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16122702","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues82
DetailsZinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PDB","id":"5EYA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FER","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues150
DetailsDomain: {"description":"Ubiquitin-like 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246333

PDB entries from 2025-12-17

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