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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5DFZ

Structure of Vps34 complex II from S. cerevisiae.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000149molecular_functionSNARE binding
A0000323cellular_componentlytic vacuole
A0000329cellular_componentfungal-type vacuole membrane
A0003674molecular_functionmolecular_function
A0005515molecular_functionprotein binding
A0005768cellular_componentendosome
A0005794cellular_componentGolgi apparatus
A0010008cellular_componentendosome membrane
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016236biological_processmacroautophagy
A0034272cellular_componentphosphatidylinositol 3-kinase complex, class III, type II
A0035493biological_processSNARE complex assembly
A0045324biological_processlate endosome to vacuole transport
A0046854biological_processphosphatidylinositol phosphate biosynthetic process
A0051365biological_processcellular response to potassium ion starvation
B0000011biological_processvacuole inheritance
B0000139cellular_componentGolgi membrane
B0000166molecular_functionnucleotide binding
B0000329cellular_componentfungal-type vacuole membrane
B0000425biological_processpexophagy
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005739cellular_componentmitochondrion
B0005768cellular_componentendosome
B0005770cellular_componentlate endosome
B0005794cellular_componentGolgi apparatus
B0006468biological_processprotein phosphorylation
B0006623biological_processprotein targeting to vacuole
B0006914biological_processautophagy
B0010008cellular_componentendosome membrane
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0016236biological_processmacroautophagy
B0016301molecular_functionkinase activity
B0016740molecular_functiontransferase activity
B0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
B0034045cellular_componentphagophore assembly site membrane
B0034271cellular_componentphosphatidylinositol 3-kinase complex, class III, type I
B0034272cellular_componentphosphatidylinositol 3-kinase complex, class III, type II
B0043130molecular_functionubiquitin binding
B0045053biological_processprotein retention in Golgi apparatus
B0045324biological_processlate endosome to vacuole transport
B0046854biological_processphosphatidylinositol phosphate biosynthetic process
B0051365biological_processcellular response to potassium ion starvation
B0071561cellular_componentnucleus-vacuole junction
B0072665biological_processprotein localization to vacuole
B0106310molecular_functionprotein serine kinase activity
B0120095cellular_componentvacuole-isolation membrane contact site
C0000045biological_processautophagosome assembly
C0000139cellular_componentGolgi membrane
C0000166molecular_functionnucleotide binding
C0000329cellular_componentfungal-type vacuole membrane
C0000407cellular_componentphagophore assembly site
C0000425biological_processpexophagy
C0004672molecular_functionprotein kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005777cellular_componentperoxisome
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0006897biological_processendocytosis
C0006914biological_processautophagy
C0010008cellular_componentendosome membrane
C0015031biological_processprotein transport
C0016020cellular_componentmembrane
C0016236biological_processmacroautophagy
C0016301molecular_functionkinase activity
C0016303molecular_function1-phosphatidylinositol-3-kinase activity
C0016740molecular_functiontransferase activity
C0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
C0033554biological_processcellular response to stress
C0034045cellular_componentphagophore assembly site membrane
C0034271cellular_componentphosphatidylinositol 3-kinase complex, class III, type I
C0034272cellular_componentphosphatidylinositol 3-kinase complex, class III, type II
C0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
C0045324biological_processlate endosome to vacuole transport
C0046854biological_processphosphatidylinositol phosphate biosynthetic process
C0048015biological_processphosphatidylinositol-mediated signaling
C0051365biological_processcellular response to potassium ion starvation
C0071561cellular_componentnucleus-vacuole junction
D0000045biological_processautophagosome assembly
D0000139cellular_componentGolgi membrane
D0000329cellular_componentfungal-type vacuole membrane
D0000407cellular_componentphagophore assembly site
D0000423biological_processmitophagy
D0000425biological_processpexophagy
D0003674molecular_functionmolecular_function
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005768cellular_componentendosome
D0005773cellular_componentvacuole
D0005774cellular_componentvacuolar membrane
D0005829cellular_componentcytosol
D0006623biological_processprotein targeting to vacuole
D0006661biological_processphosphatidylinositol biosynthetic process
D0006914biological_processautophagy
D0006995biological_processcellular response to nitrogen starvation
D0010008cellular_componentendosome membrane
D0015031biological_processprotein transport
D0016020cellular_componentmembrane
D0016236biological_processmacroautophagy
D0030674molecular_functionprotein-macromolecule adaptor activity
D0032258biological_processcytoplasm to vacuole targeting by the Cvt pathway
D0034045cellular_componentphagophore assembly site membrane
D0034271cellular_componentphosphatidylinositol 3-kinase complex, class III, type I
D0034272cellular_componentphosphatidylinositol 3-kinase complex, class III, type II
D0034727biological_processpiecemeal microautophagy of the nucleus
D0042147biological_processretrograde transport, endosome to Golgi
D0043548molecular_functionphosphatidylinositol 3-kinase binding
D0045324biological_processlate endosome to vacuole transport
D0046854biological_processphosphatidylinositol phosphate biosynthetic process
D0051365biological_processcellular response to potassium ion starvation
D0120095cellular_componentvacuole-isolation membrane contact site
Functional Information from PROSITE/UniProt
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHgDIKteNILV
ChainResidueDetails
BILE143-VAL155
site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKvg.DDLRQDqlvvQ
ChainResidueDetails
CPHE623-GLN637
site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVitYILgVgDRHldN
ChainResidueDetails
CSER716-ASN736
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues165
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues174
DetailsDomain: {"description":"C2 PI3K-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00880","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues266
DetailsDomain: {"description":"PI3K/PI4K catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues6
DetailsRegion: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues8
DetailsRegion: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues21
DetailsRegion: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues37
DetailsRepeat: {"description":"HEAT 1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues37
DetailsRepeat: {"description":"HEAT 3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues37
DetailsRepeat: {"description":"HEAT 4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues40
DetailsRepeat: {"description":"WD 1","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues39
DetailsRepeat: {"description":"WD 2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues39
DetailsRepeat: {"description":"WD 3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues40
DetailsRepeat: {"description":"WD 4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues38
DetailsRepeat: {"description":"WD 5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues32
DetailsRepeat: {"description":"WD 6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues9
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues20
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues25
DetailsRegion: {"description":"Required for membrane-association, autophagic function during starvation and normal autophagosome morphology","evidences":[{"source":"PubMed","id":"23878393","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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