5CDR

2.65 structure of S.aureus DNA gyrase and artificially nicked DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006259	biological_process	DNA metabolic process
A	0006265	biological_process	DNA topological change
B	0003677	molecular_function	DNA binding
B	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B	0005524	molecular_function	ATP binding
B	0006265	biological_process	DNA topological change
C	0003677	molecular_function	DNA binding
C	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
C	0005524	molecular_function	ATP binding
C	0006259	biological_process	DNA metabolic process
C	0006265	biological_process	DNA topological change
D	0003677	molecular_function	DNA binding
D	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
D	0005524	molecular_function	ATP binding
D	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MN A 501

Chain	Residue
A	TYR322
A	THR325
A	GLN328
A	HOH705
A	HOH809

---

site_id	AC2
Number of Residues	2
Details	binding site for residue GOL A 502

Chain	Residue
A	ASP61
A	ARG127

---

site_id	AC3
Number of Residues	4
Details	binding site for residue GOL A 503

Chain	Residue
A	PRO219
A	THR220
A	ASP96
A	MET113

---

site_id	AC4
Number of Residues	6
Details	binding site for residue MN B 701

Chain	Residue
B	ASP508
B	ASP510
B	HOH818
B	HOH842
B	HOH848
E	HOH211

---

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL C 501

Chain	Residue
C	ARG47
C	ARG48
C	GLU156
C	PRO157
C	HOH612
C	HOH677

---

site_id	AC6
Number of Residues	7
Details	binding site for residue GOL C 502

Chain	Residue
A	ARG244
A	ASN319
C	GLU251
C	GLY255
C	ARG256
C	HOH686
C	HOH709

---

site_id	AC7
Number of Residues	6
Details	binding site for residue MN D 1001

Chain	Residue
D	ASP508
D	ASP510
D	HOH1108
D	HOH1110
D	HOH1116
D	HOH1130

---

site_id	AC8
Number of Residues	7
Details	binding site for residue GOL E 101

Chain	Residue
A	PHE97
A	SER112
A	MET113
A	GLN267
A	VAL268
A	HOH681
E	DC4

---

site_id	AC9
Number of Residues	6
Details	binding site for residue GOL G 2101

Chain	Residue
A	SER84
E	DG8
F	DC2013
G	DG2009
G	DT2010
G	HOH2213

---

Functional Information from PROSITE/UniProt

site_id	PS00177
Number of Residues	9
Details	TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG

Chain	Residue	Details
B	LEU433-GLY441

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01897","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	228
Details	Domain: {"description":"Toprim","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---