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5BQB

Crystal structure of Norrin, a Wnt signalling activator, Crystal Form III

Functional Information from GO Data
ChainGOidnamespacecontents
A0000278biological_processmitotic cell cycle
A0000320biological_processre-entry into mitotic cell cycle
A0001508biological_processaction potential
A0001525biological_processangiogenesis
A0001666biological_processresponse to hypoxia
A0001890biological_processplacenta development
A0001974biological_processblood vessel remodeling
A0002088biological_processlens development in camera-type eye
A0003406biological_processretinal pigment epithelium development
A0003407biological_processneural retina development
A0005109molecular_functionfrizzled binding
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006099biological_processtricarboxylic acid cycle
A0006366biological_processtranscription by RNA polymerase II
A0006544biological_processglycine metabolic process
A0006622biological_processprotein targeting to lysosome
A0006749biological_processglutathione metabolic process
A0006954biological_processinflammatory response
A0007033biological_processvacuole organization
A0007179biological_processtransforming growth factor beta receptor signaling pathway
A0007224biological_processsmoothened signaling pathway
A0007399biological_processnervous system development
A0007601biological_processvisual perception
A0008104biological_processprotein localization
A0008283biological_processcell population proliferation
A0009069biological_processserine family amino acid metabolic process
A0009986cellular_componentcell surface
A0010467biological_processgene expression
A0010842biological_processretina layer formation
A0014004biological_processmicroglia differentiation
A0016055biological_processWnt signaling pathway
A0016358biological_processdendrite development
A0016567biological_processprotein ubiquitination
A0021554biological_processoptic nerve development
A0030182biological_processneuron differentiation
A0031290biological_processretinal ganglion cell axon guidance
A0035426biological_processextracellular matrix-cell signaling
A0035640biological_processexploration behavior
A0042803molecular_functionprotein homodimerization activity
A0045446biological_processendothelial cell differentiation
A0045893biological_processpositive regulation of DNA-templated transcription
A0046697biological_processdecidualization
A0048678biological_processresponse to axon injury
A0051402biological_processneuron apoptotic process
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0060041biological_processretina development in camera-type eye
A0060042biological_processretina morphogenesis in camera-type eye
A0060070biological_processcanonical Wnt signaling pathway
A0060221biological_processretinal rod cell differentiation
A0060856biological_processestablishment of blood-brain barrier
A0060996biological_processdendritic spine development
A0061298biological_processretina vasculature development in camera-type eye
A0061299biological_processretina vasculature morphogenesis in camera-type eye
A0061304biological_processretinal blood vessel morphogenesis
A0061518biological_processmicroglial cell proliferation
A0062023cellular_componentcollagen-containing extracellular matrix
A0070086biological_processubiquitin-dependent endocytosis
A0071456biological_processcellular response to hypoxia
A0097601biological_processretina blood vessel maintenance
A0110135biological_processNorrin signaling pathway
A1904390biological_processcone retinal bipolar cell differentiation
A1990963biological_processestablishment of blood-retinal barrier
B0000278biological_processmitotic cell cycle
B0000320biological_processre-entry into mitotic cell cycle
B0001508biological_processaction potential
B0001525biological_processangiogenesis
B0001666biological_processresponse to hypoxia
B0001890biological_processplacenta development
B0001974biological_processblood vessel remodeling
B0002088biological_processlens development in camera-type eye
B0003406biological_processretinal pigment epithelium development
B0003407biological_processneural retina development
B0005109molecular_functionfrizzled binding
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006099biological_processtricarboxylic acid cycle
B0006366biological_processtranscription by RNA polymerase II
B0006544biological_processglycine metabolic process
B0006622biological_processprotein targeting to lysosome
B0006749biological_processglutathione metabolic process
B0006954biological_processinflammatory response
B0007033biological_processvacuole organization
B0007179biological_processtransforming growth factor beta receptor signaling pathway
B0007224biological_processsmoothened signaling pathway
B0007399biological_processnervous system development
B0007601biological_processvisual perception
B0008104biological_processprotein localization
B0008283biological_processcell population proliferation
B0009069biological_processserine family amino acid metabolic process
B0009986cellular_componentcell surface
B0010467biological_processgene expression
B0010842biological_processretina layer formation
B0014004biological_processmicroglia differentiation
B0016055biological_processWnt signaling pathway
B0016358biological_processdendrite development
B0016567biological_processprotein ubiquitination
B0021554biological_processoptic nerve development
B0030182biological_processneuron differentiation
B0031290biological_processretinal ganglion cell axon guidance
B0035426biological_processextracellular matrix-cell signaling
B0035640biological_processexploration behavior
B0042803molecular_functionprotein homodimerization activity
B0045446biological_processendothelial cell differentiation
B0045893biological_processpositive regulation of DNA-templated transcription
B0046697biological_processdecidualization
B0048678biological_processresponse to axon injury
B0051402biological_processneuron apoptotic process
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0060041biological_processretina development in camera-type eye
B0060042biological_processretina morphogenesis in camera-type eye
B0060070biological_processcanonical Wnt signaling pathway
B0060221biological_processretinal rod cell differentiation
B0060856biological_processestablishment of blood-brain barrier
B0060996biological_processdendritic spine development
B0061298biological_processretina vasculature development in camera-type eye
B0061299biological_processretina vasculature morphogenesis in camera-type eye
B0061304biological_processretinal blood vessel morphogenesis
B0061518biological_processmicroglial cell proliferation
B0062023cellular_componentcollagen-containing extracellular matrix
B0070086biological_processubiquitin-dependent endocytosis
B0071456biological_processcellular response to hypoxia
B0097601biological_processretina blood vessel maintenance
B0110135biological_processNorrin signaling pathway
B1904390biological_processcone retinal bipolar cell differentiation
B1990963biological_processestablishment of blood-retinal barrier
C0000278biological_processmitotic cell cycle
C0000320biological_processre-entry into mitotic cell cycle
C0001508biological_processaction potential
C0001525biological_processangiogenesis
C0001666biological_processresponse to hypoxia
C0001890biological_processplacenta development
C0001974biological_processblood vessel remodeling
C0002088biological_processlens development in camera-type eye
C0003406biological_processretinal pigment epithelium development
C0003407biological_processneural retina development
C0005109molecular_functionfrizzled binding
C0005125molecular_functioncytokine activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0006099biological_processtricarboxylic acid cycle
C0006366biological_processtranscription by RNA polymerase II
C0006544biological_processglycine metabolic process
C0006622biological_processprotein targeting to lysosome
C0006749biological_processglutathione metabolic process
C0006954biological_processinflammatory response
C0007033biological_processvacuole organization
C0007179biological_processtransforming growth factor beta receptor signaling pathway
C0007224biological_processsmoothened signaling pathway
C0007399biological_processnervous system development
C0007601biological_processvisual perception
C0008104biological_processprotein localization
C0008283biological_processcell population proliferation
C0009069biological_processserine family amino acid metabolic process
C0009986cellular_componentcell surface
C0010467biological_processgene expression
C0010842biological_processretina layer formation
C0014004biological_processmicroglia differentiation
C0016055biological_processWnt signaling pathway
C0016358biological_processdendrite development
C0016567biological_processprotein ubiquitination
C0021554biological_processoptic nerve development
C0030182biological_processneuron differentiation
C0031290biological_processretinal ganglion cell axon guidance
C0035426biological_processextracellular matrix-cell signaling
C0035640biological_processexploration behavior
C0042803molecular_functionprotein homodimerization activity
C0045446biological_processendothelial cell differentiation
C0045893biological_processpositive regulation of DNA-templated transcription
C0046697biological_processdecidualization
C0048678biological_processresponse to axon injury
C0051402biological_processneuron apoptotic process
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0060041biological_processretina development in camera-type eye
C0060042biological_processretina morphogenesis in camera-type eye
C0060070biological_processcanonical Wnt signaling pathway
C0060221biological_processretinal rod cell differentiation
C0060856biological_processestablishment of blood-brain barrier
C0060996biological_processdendritic spine development
C0061298biological_processretina vasculature development in camera-type eye
C0061299biological_processretina vasculature morphogenesis in camera-type eye
C0061304biological_processretinal blood vessel morphogenesis
C0061518biological_processmicroglial cell proliferation
C0062023cellular_componentcollagen-containing extracellular matrix
C0070086biological_processubiquitin-dependent endocytosis
C0071456biological_processcellular response to hypoxia
C0097601biological_processretina blood vessel maintenance
C0110135biological_processNorrin signaling pathway
C1904390biological_processcone retinal bipolar cell differentiation
C1990963biological_processestablishment of blood-retinal barrier
D0000278biological_processmitotic cell cycle
D0000320biological_processre-entry into mitotic cell cycle
D0001508biological_processaction potential
D0001525biological_processangiogenesis
D0001666biological_processresponse to hypoxia
D0001890biological_processplacenta development
D0001974biological_processblood vessel remodeling
D0002088biological_processlens development in camera-type eye
D0003406biological_processretinal pigment epithelium development
D0003407biological_processneural retina development
D0005109molecular_functionfrizzled binding
D0005125molecular_functioncytokine activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0006099biological_processtricarboxylic acid cycle
D0006366biological_processtranscription by RNA polymerase II
D0006544biological_processglycine metabolic process
D0006622biological_processprotein targeting to lysosome
D0006749biological_processglutathione metabolic process
D0006954biological_processinflammatory response
D0007033biological_processvacuole organization
D0007179biological_processtransforming growth factor beta receptor signaling pathway
D0007224biological_processsmoothened signaling pathway
D0007399biological_processnervous system development
D0007601biological_processvisual perception
D0008104biological_processprotein localization
D0008283biological_processcell population proliferation
D0009069biological_processserine family amino acid metabolic process
D0009986cellular_componentcell surface
D0010467biological_processgene expression
D0010842biological_processretina layer formation
D0014004biological_processmicroglia differentiation
D0016055biological_processWnt signaling pathway
D0016358biological_processdendrite development
D0016567biological_processprotein ubiquitination
D0021554biological_processoptic nerve development
D0030182biological_processneuron differentiation
D0031290biological_processretinal ganglion cell axon guidance
D0035426biological_processextracellular matrix-cell signaling
D0035640biological_processexploration behavior
D0042803molecular_functionprotein homodimerization activity
D0045446biological_processendothelial cell differentiation
D0045893biological_processpositive regulation of DNA-templated transcription
D0046697biological_processdecidualization
D0048678biological_processresponse to axon injury
D0051402biological_processneuron apoptotic process
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0060041biological_processretina development in camera-type eye
D0060042biological_processretina morphogenesis in camera-type eye
D0060070biological_processcanonical Wnt signaling pathway
D0060221biological_processretinal rod cell differentiation
D0060856biological_processestablishment of blood-brain barrier
D0060996biological_processdendritic spine development
D0061298biological_processretina vasculature development in camera-type eye
D0061299biological_processretina vasculature morphogenesis in camera-type eye
D0061304biological_processretinal blood vessel morphogenesis
D0061518biological_processmicroglial cell proliferation
D0062023cellular_componentcollagen-containing extracellular matrix
D0070086biological_processubiquitin-dependent endocytosis
D0071456biological_processcellular response to hypoxia
D0097601biological_processretina blood vessel maintenance
D0110135biological_processNorrin signaling pathway
D1904390biological_processcone retinal bipolar cell differentiation
D1990963biological_processestablishment of blood-retinal barrier
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue CIT A 201
ChainResidue
AARG41
BSER82
AHIS43
ATHR117
ATYR122
ACIT202
AHOH302
AHOH304
AHOH313
BPHE81

site_idAC2
Number of Residues6
Detailsbinding site for residue CIT A 202
ChainResidue
ALYS102
ALYS104
ACIT201
BSER82
BTHR83
BVAL84

site_idAC3
Number of Residues1
Detailsbinding site for residue CL A 203
ChainResidue
AHOH339

site_idAC4
Number of Residues6
Detailsbinding site for residue CIT C 201
ChainResidue
BARG41
BHIS43
BTYR122
CGLN99
CSER125
CCYS126

site_idAC5
Number of Residues7
Detailsbinding site for residue CIT C 202
ChainResidue
APHE81
BARG115
BLEU116
BTHR117
CARG41
CHIS43
CTYR122

Functional Information from PROSITE/UniProt
site_idPS01185
Number of Residues37
DetailsCTCK_1 C-terminal cystine knot signature. CCrpqtsklkalrlrCsgGmrltatyryilsChCee..C
ChainResidueDetails
ACYS95-CYS131

219140

PDB entries from 2024-05-01

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