4WFH

Human TRAAK K+ channel in a Tl+ bound nonconductive conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005267	molecular_function	potassium channel activity
A	0016020	cellular_component	membrane
A	0071805	biological_process	potassium ion transmembrane transport
B	0005267	molecular_function	potassium channel activity
B	0016020	cellular_component	membrane
B	0071805	biological_process	potassium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue TL A 301

Chain	Residue
A	CYS218
A	TRP223

---

site_id	AC2
Number of Residues	10
Details	binding site for residue TL A 302

Chain	Residue
B	GLY131
B	VAL239
B	GLY240
A	ILE130
A	GLY131
A	VAL239
A	GLY240
A	TL303
A	TL307
B	ILE130

---

site_id	AC3
Number of Residues	10
Details	binding site for residue TL A 303

Chain	Residue
A	THR129
A	ILE130
A	THR238
A	VAL239
A	TL302
A	TL304
B	THR129
B	ILE130
B	THR238
B	VAL239

---

site_id	AC4
Number of Residues	5
Details	binding site for residue TL A 304

Chain	Residue
A	THR129
A	THR238
A	TL303
B	THR129
B	THR238

---

site_id	AC5
Number of Residues	4
Details	binding site for residue CA A 305

Chain	Residue
A	SER112
A	ASP115
A	SER118
A	ASP249

---

site_id	AC6
Number of Residues	6
Details	binding site for residue CA A 306

Chain	Residue
A	GLY98
A	ASP100
A	HIS111
A	HOH417
B	GLU58
B	HOH414

---

site_id	AC7
Number of Residues	9
Details	binding site for residue TL A 307

Chain	Residue
A	GLY131
A	TYR132
A	GLY240
A	PHE241
A	TL302
B	GLY131
B	TYR132
B	GLY240
B	PHE241

---

site_id	AC8
Number of Residues	2
Details	binding site for residue TL B 302

Chain	Residue
B	CYS218
B	TRP223

---

site_id	AC9
Number of Residues	1
Details	binding site for residue D10 B 303

Chain	Residue
B	PHE272

---

site_id	AD1
Number of Residues	3
Details	binding site for residue CA G 301

Chain	Residue
G	GLU10
G	LYS19
G	HOH407

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
D	TYR191-HIS197

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	172
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"22282805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500157","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Intramembrane: {"description":"Helical; Name=Pore helix 1","evidences":[{"source":"PubMed","id":"22282805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500157","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	22
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"22282805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500157","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	48
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"22282805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500157","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	42
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"22282805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500157","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	26
Details	Intramembrane: {"description":"Helical; Name=Pore helix 2","evidences":[{"source":"PubMed","id":"22282805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500157","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	10
Details	Region: {"description":"Selectivity filter 1","evidences":[{"source":"PubMed","id":"22282805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500157","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	10
Details	Region: {"description":"Selectivity filter 2","evidences":[{"source":"PubMed","id":"22282805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25500157","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34390650","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LJ5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23341632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25471887","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4I9W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WFE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P57789","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---