4UEL
UCH-L5 in complex with ubiquitin-propargyl bound to the RPN13 DEUBAD domain
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000502 | cellular_component | proteasome complex |
A | 0000723 | biological_process | telomere maintenance |
A | 0003723 | molecular_function | RNA binding |
A | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
A | 0004866 | molecular_function | endopeptidase inhibitor activity |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005730 | cellular_component | nucleolus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006275 | biological_process | regulation of DNA replication |
A | 0006281 | biological_process | DNA repair |
A | 0006282 | biological_process | regulation of DNA repair |
A | 0006310 | biological_process | DNA recombination |
A | 0006338 | biological_process | chromatin remodeling |
A | 0006508 | biological_process | proteolysis |
A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
A | 0008234 | molecular_function | cysteine-type peptidase activity |
A | 0016579 | biological_process | protein deubiquitination |
A | 0021670 | biological_process | lateral ventricle development |
A | 0030901 | biological_process | midbrain development |
A | 0031011 | cellular_component | Ino80 complex |
A | 0031597 | cellular_component | cytosolic proteasome complex |
A | 0032435 | biological_process | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
A | 0033044 | biological_process | regulation of chromosome organization |
A | 0045739 | biological_process | positive regulation of DNA repair |
A | 0045880 | biological_process | positive regulation of smoothened signaling pathway |
A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
A | 0045995 | biological_process | regulation of embryonic development |
A | 0048853 | biological_process | forebrain morphogenesis |
A | 0051726 | biological_process | regulation of cell cycle |
A | 0060382 | biological_process | regulation of DNA strand elongation |
A | 0061136 | biological_process | regulation of proteasomal protein catabolic process |
A | 0070628 | molecular_function | proteasome binding |
A | 1904507 | biological_process | positive regulation of telomere maintenance in response to DNA damage |
C | 0005634 | cellular_component | nucleus |
C | 0005737 | cellular_component | cytoplasm |
Functional Information from PROSITE/UniProt
site_id | PS00299 |
Number of Residues | 26 |
Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
Chain | Residue | Details |
B | LYS27-ASP52 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | SITE: Interacts with activating enzyme |
Chain | Residue | Details |
B | ARG54 | |
B | ARG72 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | SITE: Essential for function |
Chain | Residue | Details |
B | HIS68 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 |
Chain | Residue | Details |
B | SER65 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 |
Chain | Residue | Details |
B | THR66 | |
A | HIS289 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742 |
Chain | Residue | Details |
B | AYE76 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
Chain | Residue | Details |
B | LYS6 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
Chain | Residue | Details |
B | AYE76 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 |
Chain | Residue | Details |
B | LYS11 | |
B | LYS48 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
Chain | Residue | Details |
B | LYS27 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 |
Chain | Residue | Details |
B | LYS29 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
Chain | Residue | Details |
B | LYS33 |
site_id | SWS_FT_FI12 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 |
Chain | Residue | Details |
B | LYS63 |