4QBT

Crystal structure of tyrosine bound human tyrosyl tRNA synthetase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004831	molecular_function	tyrosine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006437	biological_process	tyrosyl-tRNA aminoacylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 A 501

Chain	Residue
A	HIS305
A	PRO306
A	GLY307
A	ASP308
A	HOH687
A	HOH689

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 502

Chain	Residue
A	TYR52
A	TYR97
A	HOH601
A	THR42
A	ALA43
A	THR45

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 503

Chain	Residue
A	HIS12
A	ARG16

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 504

Chain	Residue
A	SER126
A	LYS127
A	GLU128
A	LYS146

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 505

Chain	Residue
A	LYS26
A	ARG34

---

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE TYR A 506

Chain	Residue
A	TYR39
A	GLY41
A	LEU72
A	ALA74
A	HIS77
A	VAL152
A	TYR166
A	GLN170
A	ASP173
A	GLN182
A	GLN188
A	HOH601
A	HOH622

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 A 507

Chain	Residue
A	LYS282
A	TRP283
A	HOH747

---

site_id	AC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 A 508

Chain	Residue
A	HIS49
A	VAL50
A	ALA51
A	GLY217
A	LEU218
A	THR219
A	LYS231
A	ILE232
A	HOH631
A	HOH684

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE K A 509

Chain	Residue
A	THR45

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Motif: {"description":"'HIGH' region","evidences":[{"source":"PubMed","id":"14671330","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"22291016","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25533949","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4Q93","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14671330","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4QBT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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