4Q9M
Crystal structure of UPPs in complex with FPP and an allosteric inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008834 | molecular_function | ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity |
| A | 0016094 | biological_process | polyprenol biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0045547 | molecular_function | ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008834 | molecular_function | ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity |
| B | 0016094 | biological_process | polyprenol biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0045547 | molecular_function | ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 2ZW A 301 |
| Chain | Residue |
| A | MET49 |
| A | PHE143 |
| A | FPP302 |
| A | GLN53 |
| A | ALA71 |
| A | ILE87 |
| A | PRO91 |
| A | TYR98 |
| A | VAL99 |
| A | LEU102 |
| A | ALA129 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE FPP A 302 |
| Chain | Residue |
| A | MET27 |
| A | ASP28 |
| A | GLY29 |
| A | ASN30 |
| A | GLY31 |
| A | ARG32 |
| A | ARG41 |
| A | HIS45 |
| A | LEU52 |
| A | ALA71 |
| A | ARG79 |
| A | ILE87 |
| A | 2ZW301 |
| A | CD303 |
| A | HOH494 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CD A 303 |
| Chain | Residue |
| A | ASP28 |
| A | FPP302 |
| A | HOH404 |
| A | HOH419 |
| A | HOH433 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CD A 304 |
| Chain | Residue |
| A | GLU114 |
| A | ASP116 |
| A | HOH403 |
| B | ASP81 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CD A 305 |
| Chain | Residue |
| A | GLU176 |
| A | HOH406 |
| A | HOH408 |
| B | HOH404 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CD A 306 |
| Chain | Residue |
| A | ASP191 |
| A | HOH451 |
| A | HOH459 |
| A | HOH478 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CD A 307 |
| Chain | Residue |
| A | ASP96 |
| A | HOH588 |
| A | HOH596 |
| A | HOH599 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CD A 308 |
| Chain | Residue |
| A | GLU50 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CD A 309 |
| Chain | Residue |
| A | GLU204 |
| A | HOH552 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CD A 310 |
| Chain | Residue |
| A | GLU101 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CD A 311 |
| Chain | Residue |
| A | ASP163 |
| A | HOH541 |
| A | HOH561 |
| site_id | BC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 2ZW B 301 |
| Chain | Residue |
| B | MET49 |
| B | GLN53 |
| B | ALA71 |
| B | ILE87 |
| B | PRO91 |
| B | TYR98 |
| B | VAL99 |
| B | LEU102 |
| B | ALA129 |
| B | PHE143 |
| B | FPP302 |
| site_id | BC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE FPP B 302 |
| Chain | Residue |
| B | MET27 |
| B | ASP28 |
| B | GLY29 |
| B | ASN30 |
| B | GLY31 |
| B | ARG32 |
| B | ARG41 |
| B | HIS45 |
| B | ALA71 |
| B | ARG79 |
| B | ILE87 |
| B | 2ZW301 |
| B | CD303 |
| B | HOH439 |
| B | HOH507 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CD B 303 |
| Chain | Residue |
| B | ASP28 |
| B | FPP302 |
| B | HOH420 |
| B | HOH436 |
| B | HOH439 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CD B 304 |
| Chain | Residue |
| B | ASP191 |
| B | HOH409 |
| B | HOH412 |
| B | HOH606 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CD B 305 |
| Chain | Residue |
| B | GLU75 |
| B | HOH407 |
| B | HOH421 |
| B | HOH490 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CD B 306 |
| Chain | Residue |
| A | HOH401 |
| B | GLU176 |
| B | HOH581 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CD B 307 |
| Chain | Residue |
| B | HOH531 |
| A | HIS246 |
| B | GLU204 |
| B | HOH479 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CD B 308 |
| Chain | Residue |
| B | ASP163 |
| B | HOH518 |
| B | HOH534 |
| B | HOH538 |
Functional Information from PROSITE/UniProt
| site_id | PS01066 |
| Number of Residues | 18 |
| Details | UPP_SYNTHASE Undecaprenyl pyrophosphate synthase family signature. DLIIRTSGelRlSnFLPW |
| Chain | Residue | Details |
| A | ASP196-TRP213 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01139","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_01139","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 30 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01139","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
