4Q9M
Crystal structure of UPPs in complex with FPP and an allosteric inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0004659 | molecular_function | prenyltransferase activity |
A | 0005829 | cellular_component | cytosol |
A | 0008834 | molecular_function | di-trans,poly-cis-undecaprenyl-diphosphate synthase activity |
A | 0016094 | biological_process | polyprenol biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
A | 0030145 | molecular_function | manganese ion binding |
A | 0045547 | molecular_function | dehydrodolichyl diphosphate synthase activity |
A | 0046872 | molecular_function | metal ion binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0004659 | molecular_function | prenyltransferase activity |
B | 0005829 | cellular_component | cytosol |
B | 0008834 | molecular_function | di-trans,poly-cis-undecaprenyl-diphosphate synthase activity |
B | 0016094 | biological_process | polyprenol biosynthetic process |
B | 0016740 | molecular_function | transferase activity |
B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
B | 0030145 | molecular_function | manganese ion binding |
B | 0045547 | molecular_function | dehydrodolichyl diphosphate synthase activity |
B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE 2ZW A 301 |
Chain | Residue |
A | MET49 |
A | PHE143 |
A | FPP302 |
A | GLN53 |
A | ALA71 |
A | ILE87 |
A | PRO91 |
A | TYR98 |
A | VAL99 |
A | LEU102 |
A | ALA129 |
site_id | AC2 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE FPP A 302 |
Chain | Residue |
A | MET27 |
A | ASP28 |
A | GLY29 |
A | ASN30 |
A | GLY31 |
A | ARG32 |
A | ARG41 |
A | HIS45 |
A | LEU52 |
A | ALA71 |
A | ARG79 |
A | ILE87 |
A | 2ZW301 |
A | CD303 |
A | HOH494 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CD A 303 |
Chain | Residue |
A | ASP28 |
A | FPP302 |
A | HOH404 |
A | HOH419 |
A | HOH433 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CD A 304 |
Chain | Residue |
A | GLU114 |
A | ASP116 |
A | HOH403 |
B | ASP81 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CD A 305 |
Chain | Residue |
A | GLU176 |
A | HOH406 |
A | HOH408 |
B | HOH404 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CD A 306 |
Chain | Residue |
A | ASP191 |
A | HOH451 |
A | HOH459 |
A | HOH478 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CD A 307 |
Chain | Residue |
A | ASP96 |
A | HOH588 |
A | HOH596 |
A | HOH599 |
site_id | AC8 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE CD A 308 |
Chain | Residue |
A | GLU50 |
site_id | AC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CD A 309 |
Chain | Residue |
A | GLU204 |
A | HOH552 |
site_id | BC1 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE CD A 310 |
Chain | Residue |
A | GLU101 |
site_id | BC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CD A 311 |
Chain | Residue |
A | ASP163 |
A | HOH541 |
A | HOH561 |
site_id | BC3 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE 2ZW B 301 |
Chain | Residue |
B | MET49 |
B | GLN53 |
B | ALA71 |
B | ILE87 |
B | PRO91 |
B | TYR98 |
B | VAL99 |
B | LEU102 |
B | ALA129 |
B | PHE143 |
B | FPP302 |
site_id | BC4 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE FPP B 302 |
Chain | Residue |
B | MET27 |
B | ASP28 |
B | GLY29 |
B | ASN30 |
B | GLY31 |
B | ARG32 |
B | ARG41 |
B | HIS45 |
B | ALA71 |
B | ARG79 |
B | ILE87 |
B | 2ZW301 |
B | CD303 |
B | HOH439 |
B | HOH507 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CD B 303 |
Chain | Residue |
B | ASP28 |
B | FPP302 |
B | HOH420 |
B | HOH436 |
B | HOH439 |
site_id | BC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CD B 304 |
Chain | Residue |
B | ASP191 |
B | HOH409 |
B | HOH412 |
B | HOH606 |
site_id | BC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CD B 305 |
Chain | Residue |
B | GLU75 |
B | HOH407 |
B | HOH421 |
B | HOH490 |
site_id | BC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CD B 306 |
Chain | Residue |
A | HOH401 |
B | GLU176 |
B | HOH581 |
site_id | BC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CD B 307 |
Chain | Residue |
B | HOH531 |
A | HIS246 |
B | GLU204 |
B | HOH479 |
site_id | CC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CD B 308 |
Chain | Residue |
B | ASP163 |
B | HOH518 |
B | HOH534 |
B | HOH538 |
Functional Information from PROSITE/UniProt
site_id | PS01066 |
Number of Residues | 18 |
Details | UPP_SYNTHASE Undecaprenyl pyrophosphate synthase family signature. DLIIRTSGelRlSnFLPW |
Chain | Residue | Details |
A | ASP196-TRP213 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01139 |
Chain | Residue | Details |
A | ASP28 | |
B | ASP28 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_01139 |
Chain | Residue | Details |
A | ASN76 | |
B | ASN76 |
site_id | SWS_FT_FI3 |
Number of Residues | 22 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01139 |
Chain | Residue | Details |
A | HIS45 | |
A | SER73 | |
A | TRP77 | |
A | ARG79 | |
A | ARG200 | |
A | ARG206 | |
A | GLU219 | |
B | ASP28 | |
B | GLY29 | |
B | TRP33 | |
B | ARG41 | |
B | HIS45 | |
B | SER73 | |
B | TRP77 | |
B | ARG79 | |
B | ARG200 | |
B | ARG206 | |
B | GLU219 | |
A | ASP28 | |
A | GLY29 | |
A | TRP33 | |
A | ARG41 |