4NCN
Crystal structure of eukaryotic translation initiation factor eIF5B (517-858) from Chaetomium thermophilum in complex with GTP
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE GTP A 1001 |
| Chain | Residue |
| A | VAL532 |
| A | ILE556 |
| A | THR557 |
| A | GLY597 |
| A | ASN648 |
| A | LYS649 |
| A | ASP651 |
| A | ARG652 |
| A | SER716 |
| A | ALA717 |
| A | HIS718 |
| A | ASP533 |
| A | MG1002 |
| A | NA1003 |
| A | HOH1101 |
| A | HOH1102 |
| A | HOH1103 |
| A | HOH1146 |
| A | HOH1156 |
| A | THR534 |
| A | GLY535 |
| A | LYS536 |
| A | THR537 |
| A | LYS538 |
| A | GLN549 |
| A | GLY555 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1002 |
| Chain | Residue |
| A | THR537 |
| A | THR557 |
| A | GTP1001 |
| A | HOH1101 |
| A | HOH1102 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 1003 |
| Chain | Residue |
| A | ASP533 |
| A | GLY555 |
| A | ILE556 |
| A | GTP1001 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1004 |
| Chain | Residue |
| A | LYS542 |
| A | ILE543 |
| A | GLN545 |
| A | LYS573 |
| A | ILE723 |
| A | PRO724 |
| A | HOH1110 |
| A | HOH1126 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 1005 |
| Chain | Residue |
| A | HIS531 |
| A | VAL532 |
| A | ASP533 |
| A | THR534 |
| A | ASP620 |
| A | HIS623 |
| A | GLU626 |
| A | LYS649 |
| A | HOH1296 |
| A | HOH1323 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1006 |
| Chain | Residue |
| A | ASP541 |
| A | LYS542 |
| A | GLN545 |
| A | THR546 |
| A | ASN547 |
| A | HOH1116 |
| A | HOH1203 |
| site_id | AC7 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE GTP B 1001 |
| Chain | Residue |
| B | VAL532 |
| B | ASP533 |
| B | THR534 |
| B | GLY535 |
| B | LYS536 |
| B | THR537 |
| B | LYS538 |
| B | GLN549 |
| B | GLY555 |
| B | ILE556 |
| B | THR557 |
| B | GLY597 |
| B | ASN648 |
| B | LYS649 |
| B | ASP651 |
| B | ARG652 |
| B | SER716 |
| B | ALA717 |
| B | HIS718 |
| B | MG1002 |
| B | NA1003 |
| B | HOH1101 |
| B | HOH1102 |
| B | HOH1103 |
| B | HOH1123 |
| B | HOH1137 |
| B | HOH1262 |
| B | HOH1343 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 1002 |
| Chain | Residue |
| B | THR537 |
| B | THR557 |
| B | GTP1001 |
| B | HOH1101 |
| B | HOH1102 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA B 1003 |
| Chain | Residue |
| B | ASP533 |
| B | GLY555 |
| B | ILE556 |
| B | GTP1001 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACY B 1004 |
| Chain | Residue |
| B | ARG775 |
| B | HOH1197 |
| B | HOH1203 |
| B | HOH1347 |
| B | GLY772 |
| B | ILE773 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1005 |
| Chain | Residue |
| B | LEU521 |
| B | LYS571 |
| B | PHE585 |
| B | LYS586 |
| B | VAL587 |
| B | PRO588 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1006 |
| Chain | Residue |
| B | LYS538 |
| B | ASP541 |
| B | LYS542 |
| B | THR546 |
| B | ASN547 |
| B | ALA717 |
| B | HOH1159 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 1007 |
| Chain | Residue |
| B | LYS542 |
| B | ILE543 |
| B | GLN545 |
| B | LYS573 |
| B | ILE723 |
| B | HOH1106 |
| B | HOH1169 |
| B | HOH1297 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 1008 |
| Chain | Residue |
| B | THR546 |
| B | ASN547 |
| B | VAL548 |
| B | GLU804 |
| B | HOH1253 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 442 |
| Details | Domain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Region: {"description":"G1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Region: {"description":"G2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Region: {"description":"G3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Region: {"description":"G4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Region: {"description":"G5","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24686316","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25225612","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25225612","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TMV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TMX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25225612","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
