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4H9G

Probing EF-Tu with a very small brominated fragment library identifies the CCA pocket

Functional Information from GO Data
ChainGOidnamespacecontents
A0003746molecular_functiontranslation elongation factor activity
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006412biological_processtranslation
A0006414biological_processtranslational elongation
Functional Information from PDB Data
site_idAC1
Number of Residues26
DetailsBINDING SITE FOR RESIDUE GNP A 501
ChainResidue
AVAL20
ATHR62
AGLY84
AASN136
ALYS137
AASP139
AMET140
ASER174
AALA175
ALEU176
AGLN354
AASP21
AMG502
AHOH612
AHOH617
AHOH628
AHOH664
AHOH698
AHOH714
AHIS22
AGLY23
ALYS24
ATHR25
ATHR26
ATYR47
AILE61

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 502
ChainResidue
ATHR25
ATHR62
AGNP501
AHOH612
AHOH628

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NH4 A 503
ChainResidue
AILE50
AASP51
AGLU56
ATHR62
AASN64
AHOH609

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 504
ChainResidue
AMET113
APRO114
AARG117
AHOH748
AHOH884
AHOH885

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 505
ChainResidue
ALYS45
AHIS67
AHIS273
AARG274
AHOH908
AHOH942

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 506
ChainResidue
AARG59
AHIS85
AHOH722
AHOH901
AHOH951

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 507
ChainResidue
ATYR130
AARG295
AHOH681
AHOH764
AHOH894
AHOH943

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 508
ChainResidue
ALYS248
AARG291
AHOH794
AHOH948

site_idAC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 509
ChainResidue
AARG330
AHIS331
ATHR332

site_idBC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 510
ChainResidue
AARG57
AGLY358
AHOH878

site_idBC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 511
ChainResidue
AGLN181
AARG184
AASN185
AHOH931

site_idBC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE 14J A 512
ChainResidue
APHE229
AILE231
AARG234
AGLU271
AGLY287
ALEU289

Functional Information from PROSITE/UniProt
site_idPS00301
Number of Residues16
DetailsG_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DKapeERaRGITIntA
ChainResidueDetails
AASP51-ALA66

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING:
ChainResidueDetails
AGLY18
AASP81
AASN136

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250
ChainResidueDetails
ATHR394

227344

PDB entries from 2024-11-13

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