4G0A

Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5'-GG Sequence for RTPase activity

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003723	molecular_function	RNA binding
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0005524	molecular_function	ATP binding
A	0016787	molecular_function	hydrolase activity
A	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
A	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
A	0019079	biological_process	viral genome replication
A	0030430	cellular_component	host cell cytoplasm
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0003723	molecular_function	RNA binding
B	0004550	molecular_function	nucleoside diphosphate kinase activity
B	0005524	molecular_function	ATP binding
B	0016787	molecular_function	hydrolase activity
B	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
B	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
B	0019079	biological_process	viral genome replication
B	0030430	cellular_component	host cell cytoplasm
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0003723	molecular_function	RNA binding
C	0004550	molecular_function	nucleoside diphosphate kinase activity
C	0005524	molecular_function	ATP binding
C	0016787	molecular_function	hydrolase activity
C	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
C	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
C	0019079	biological_process	viral genome replication
C	0030430	cellular_component	host cell cytoplasm
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0003723	molecular_function	RNA binding
D	0004550	molecular_function	nucleoside diphosphate kinase activity
D	0005524	molecular_function	ATP binding
D	0016787	molecular_function	hydrolase activity
D	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
D	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
D	0019079	biological_process	viral genome replication
D	0030430	cellular_component	host cell cytoplasm
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 1201

Chain	Residue
A	THR220
A	HIS221
A	GLY222
A	LYS223
A	HIS225
A	ARG227

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL B 1200

Chain	Residue
B	LYS223
B	HIS225
B	ARG227
B	THR220
B	HIS221
B	GLY222

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL C 401

Chain	Residue
C	THR220
C	HIS221
C	GLY222
C	LYS223
C	HIS225
C	ARG227

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA C 402

Chain	Residue
C	ASP39
C	LYS42
C	PRO55
C	HOH613

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL D 401

Chain	Residue
D	THR220
D	HIS221
D	GLY222
D	LYS223
D	HIS225
D	ARG227

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: For NTPase and RTPase activities => ECO:0000255|HAMAP-Rule:MF_04089, ECO:0000305|PubMed:17804496

Chain	Residue	Details
A	HIS225
B	HIS225
C	HIS225
D	HIS225

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site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04089, ECO:0007744|PDB:2R7P

Chain	Residue	Details
A	SER107
C	LYS188
C	HIS221
C	ARG227
D	SER107
D	LYS188
D	HIS221
D	ARG227
A	LYS188
A	HIS221
A	ARG227
B	SER107
B	LYS188
B	HIS221
B	ARG227
C	SER107

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