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4FBK

Crystal structure of a covalently fused Nbs1-Mre11 complex with one manganese ion per active site

Functional Information from GO Data
ChainGOidnamespacecontents
A0004519molecular_functionendonuclease activity
A0004520molecular_functionDNA endonuclease activity
A0005634cellular_componentnucleus
A0006302biological_processdouble-strand break repair
A0008296molecular_function3'-5'-DNA exonuclease activity
A0016787molecular_functionhydrolase activity
A0030145molecular_functionmanganese ion binding
A0030870cellular_componentMre11 complex
B0004519molecular_functionendonuclease activity
B0004520molecular_functionDNA endonuclease activity
B0005634cellular_componentnucleus
B0006302biological_processdouble-strand break repair
B0008296molecular_function3'-5'-DNA exonuclease activity
B0016787molecular_functionhydrolase activity
B0030145molecular_functionmanganese ion binding
B0030870cellular_componentMre11 complex
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE SO4 A 1501
ChainResidue
AASP1065
AHOH1693
AILE1066
APHE1067
AHIS1131
AGLY1132
AHIS1134
ALEU1146
AHOH1648
AHOH1656

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 1502
ChainResidue
ALYS1071
AHOH1618
BSER1073
BARG1074

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 1503
ChainResidue
ASER1073
AARG1074
AHOH1607
BLYS1071

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN A 1504
ChainResidue
AASP1025
AHIS1027
AASP1065
AHIS1250
AHIS1252

site_idAC5
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 B 1501
ChainResidue
BASP1065
BILE1066
BPHE1067
BHIS1131
BGLY1132
BHIS1134
BLEU1146
BHOH1640
BHOH1657

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN B 1502
ChainResidue
BASP1025
BHIS1027
BASP1065
BHIS1250
BHIS1252

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000255|PIRSR:PIRSR000882-1
ChainResidueDetails
AHIS1134
BHIS1134

site_idSWS_FT_FI2
Number of Residues14
DetailsBINDING: BINDING => ECO:0000269|PubMed:22705791, ECO:0007744|PDB:4FBQ, ECO:0007744|PDB:4FBW, ECO:0007744|PDB:4FCX
ChainResidueDetails
AASP1025
BASP1065
BASN1133
BHIS1222
BHIS1250
BHIS1252
AHIS1027
AASP1065
AASN1133
AHIS1222
AHIS1250
AHIS1252
BASP1025
BHIS1027

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PDB entries from 2024-11-06

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