4C8K

Crystal structure of the large fragment of DNA polymerase I from Thermus Aquaticus in a partially closed complex with the artificial base pair d5SICS-dNaMTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001882	molecular_function	nucleoside binding
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 1833

Chain	Residue
A	PHE724
A	TYR811

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site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE BMR A 1834

Chain	Residue
A	TYR671
A	MG1835
A	HOH2076
A	HOH2085
A	HOH2086
B	DOC112
C	DG205
A	ARG587
A	GLN613
A	HIS639
A	ARG659
A	ARG660
A	LYS663
A	PHE667

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 1835

Chain	Residue
A	BMR1834
A	HOH2085
A	HOH2086
A	HOH2111

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 1113

Chain	Residue
B	HOH2004
B	HOH2005
B	HOH2008
B	HOH2016
B	HOH2017
B	HOH2018

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 1217

Chain	Residue
B	DA102
C	DT212
C	DG213
C	DG214

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE TRS C 1218

Chain	Residue
C	DG205
C	DG206

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Functional Information from PROSITE/UniProt

site_id	PS00447
Number of Residues	20
Details	DNA_POLYMERASE_A DNA polymerase family A signature. RraAKtinFGvlYgmSahrL

Chain	Residue	Details
A	ARG659-LEU678

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	422
Details	Region: {"description":"Polymerase","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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