4C2B
Crystal Structure of High-Affinity von Willebrand Factor A1 domain with Disulfide Mutation in Complex with High Affinity GPIb alpha
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 H 1266 |
| Chain | Residue |
| C | LEU1427 |
| C | LYS1430 |
| H | LYS19 |
| H | ARG21 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 G 2466 |
| Chain | Residue |
| G | ARG1336 |
| G | PRO1337 |
| G | SER1338 |
| G | ARG1341 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2467 |
| Chain | Residue |
| C | ARG1336 |
| C | PRO1337 |
| C | SER1338 |
| B | PRO188 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 E 2466 |
| Chain | Residue |
| E | ARG1336 |
| E | PRO1337 |
| E | SER1338 |
| E | HOH2005 |
| H | PRO188 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1266 |
| Chain | Residue |
| B | PRO141 |
| B | GLY142 |
| B | PRO164 |
| B | GLY166 |
| C | SER1338 |
| C | ARG1342 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 H 1267 |
| Chain | Residue |
| E | SER1338 |
| H | PRO141 |
| H | GLY142 |
| H | PRO164 |
| H | ALA165 |
| H | GLY166 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1266 |
| Chain | Residue |
| A | SER1338 |
| A | ARG1342 |
| D | PRO141 |
| D | ALA165 |
| D | GLY166 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 G 2467 |
| Chain | Residue |
| F | GLY166 |
| G | SER1338 |
| G | ARG1342 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 F 1266 |
| Chain | Residue |
| A | LYS1423 |
| A | LEU1427 |
| F | LYS19 |
| F | HOH2002 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2266 |
| Chain | Residue |
| A | HIS1419 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG G 2468 |
| Chain | Residue |
| G | ALA1350 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MES A 2466 |
| Chain | Residue |
| A | ARG1336 |
| A | PRO1337 |
| A | SER1338 |
| A | ARG1341 |
| D | GLU162 |
| D | GLU212 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 704 |
| Details | Domain: {"description":"VWFA 1; binding site for platelet glycoprotein Ib","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 80 |
| Details | Repeat: {"description":"LRR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"LRR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"LRR 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 80 |
| Details | Repeat: {"description":"LRR 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"LRR 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"LRR 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"LRR 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3497398","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36740532","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"3497398","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
