4C2B

Crystal Structure of High-Affinity von Willebrand Factor A1 domain with Disulfide Mutation in Complex with High Affinity GPIb alpha

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 H 1266

Chain	Residue
C	LEU1427
C	LYS1430
H	LYS19
H	ARG21

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 G 2466

Chain	Residue
G	ARG1336
G	PRO1337
G	SER1338
G	ARG1341

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 2467

Chain	Residue
C	ARG1336
C	PRO1337
C	SER1338
B	PRO188

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 2466

Chain	Residue
E	ARG1336
E	PRO1337
E	SER1338
E	HOH2005
H	PRO188

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 1266

Chain	Residue
B	PRO141
B	GLY142
B	PRO164
B	GLY166
C	SER1338
C	ARG1342

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 H 1267

Chain	Residue
E	SER1338
H	PRO141
H	GLY142
H	PRO164
H	ALA165
H	GLY166

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 1266

Chain	Residue
A	SER1338
A	ARG1342
D	PRO141
D	ALA165
D	GLY166

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 G 2467

Chain	Residue
F	GLY166
G	SER1338
G	ARG1342

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 1266

Chain	Residue
A	LYS1423
A	LEU1427
F	LYS19
F	HOH2002

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 2266

Chain	Residue
A	HIS1419

---

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG G 2468

Chain	Residue
G	ALA1350

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MES A 2466

Chain	Residue
A	ARG1336
A	PRO1337
A	SER1338
A	ARG1341
D	GLU162
D	GLU212

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	MOD_RES: Sulfotyrosine => ECO:0000269|PubMed:12087105

Chain	Residue	Details
B	TYR276
B	TYR278
B	TYR279
D	TYR276
D	TYR278
D	TYR279
F	TYR276
F	TYR278
F	TYR279
H	TYR276
H	TYR278
H	TYR279

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:3497398, ECO:0000269|PubMed:36740532

Chain	Residue	Details
B	ARG21
D	ARG21
F	ARG21
H	ARG21

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3497398

Chain	Residue	Details
B	ARG159
D	ARG159
F	ARG159
H	ARG159

---