4AYE

Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 1 E283AE304A mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0009279	cellular_component	cell outer membrane
C	0097691	cellular_component	bacterial extracellular vesicle
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0009279	cellular_component	cell outer membrane
D	0097691	cellular_component	bacterial extracellular vesicle
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0009279	cellular_component	cell outer membrane
F	0097691	cellular_component	bacterial extracellular vesicle

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1444

Chain	Residue
A	GLY350
A	LYS351
A	TYR352
D	ALA283
D	GLY285
D	SER286

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO F 1322

Chain	Residue
F	ARG312
F	HIS313
F	HOH2017
F	GLN193
F	PHE194
F	ILE311

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1445

Chain	Residue
A	GLY350
A	HIS373
A	CYS374
B	ASN396
B	HIS417
D	LYS306

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO E 1444

Chain	Residue
E	TYR327
E	PRO328
E	ASP329
E	ILE330
E	GLY334
E	LEU335

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 1444

Chain	Residue
B	ARG387
B	CYS389
B	TYR390
B	GLY435
B	TRP436

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO D 1323

Chain	Residue
C	GLY186
D	ALA190
D	LYS191
D	ARG192

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 1323

Chain	Residue
B	ARG341
C	SER302
C	ALA303
C	ALA304

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO C 1324

Chain	Residue
C	SER98
C	THR100
C	ALA200

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO E 1445

Chain	Residue
C	GLN281
E	HIS360
E	LYS388
E	TYR390

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 1445

Chain	Residue
B	LYS351
B	TYR353
C	SER276

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO E 1446

Chain	Residue
E	ASP329
E	ILE330

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1446

Chain	Residue
A	GLY419
E	GLN376

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO C 1325

Chain	Residue
C	GLY95
C	LEU96
C	GLN97
C	SER98
C	HOH2041

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1447

Chain	Residue
A	ARG341
D	SER286
D	SER288

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D 1324

Chain	Residue
D	ARG192
D	GLN193
D	PHE194
D	ARG312
D	HIS313

---

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO E 1447

Chain	Residue
E	PHE391
E	PRO392
E	LEU394
E	TYR398
E	ASN399
E	GLN400
E	ASN401
E	HIS402

---

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 1446

Chain	Residue
B	TRP369
B	ASP370
C	GLN193

---

site_id	BC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO B 1447

Chain	Residue
B	PHE391
B	PRO392
B	TYR393
B	LEU394
B	TYR398
B	ASN399
B	GLN400
B	ASN401
B	HIS402

---

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1448

Chain	Residue
A	THR321
A	LYS323

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	186
Details	Domain: {"description":"Sushi 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00302","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	189
Details	Region: {"description":"Domain B","evidences":[{"source":"PubMed","id":"15664958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	270
Details	Region: {"description":"Domain C","evidences":[{"source":"PubMed","id":"15664958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Site: {"description":"Important for antibody recognition","evidences":[{"source":"PubMed","id":"15664958","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---