Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004407 | molecular_function | histone deacetylase activity |
| B | 0004407 | molecular_function | histone deacetylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 500 |
| Chain | Residue |
| A | ASP170 |
| A | HIS172 |
| A | ASP259 |
| A | ACT501 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ACT A 501 |
| Chain | Residue |
| A | ASP259 |
| A | GLY296 |
| A | TYR298 |
| A | ZN500 |
| A | HIS134 |
| A | HIS135 |
| A | GLY143 |
| A | ASP170 |
| A | HIS172 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 503 |
| Chain | Residue |
| A | ASP168 |
| A | ASP170 |
| A | HIS172 |
| A | SER191 |
| A | PHE192 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 504 |
| Chain | Residue |
| A | PHE181 |
| A | THR184 |
| A | VAL187 |
| A | TYR217 |
| A | HOH2087 |
| A | HOH2090 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 505 |
| Chain | Residue |
| A | GLN113 |
| A | THR116 |
| A | HOH2070 |
| B | ARG265 |
| D | I0P501 |
| D | HOH2011 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 506 |
| Chain | Residue |
| A | THR116 |
| A | ASN119 |
| A | ASN120 |
| A | GLU156 |
| A | TYR160 |
| D | LYS449 |
| D | I0P501 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 500 |
| Chain | Residue |
| B | ASP170 |
| B | HIS172 |
| B | ASP259 |
| B | ACT501 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ACT B 501 |
| Chain | Residue |
| B | HIS134 |
| B | HIS135 |
| B | ASP170 |
| B | HIS172 |
| B | ASP259 |
| B | GLY296 |
| B | TYR298 |
| B | ZN500 |
| C | MET412 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 503 |
| Chain | Residue |
| B | ASP168 |
| B | ASP170 |
| B | HIS172 |
| B | SER191 |
| B | PHE192 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K B 504 |
| Chain | Residue |
| B | PHE181 |
| B | THR184 |
| B | VAL187 |
| B | TYR217 |
| B | HOH2071 |
| B | HOH2075 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 505 |
| Chain | Residue |
| A | ARG265 |
| A | HOH2130 |
| B | TYR51 |
| B | GLN113 |
| B | THR116 |
| C | I0P501 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 506 |
| Chain | Residue |
| B | ASN119 |
| B | ASN120 |
| B | GLU156 |
| B | TYR160 |
| C | LYS449 |
| C | TYR470 |
| C | I0P501 |
| site_id | BC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE I0P C 501 |
| Chain | Residue |
| A | HIS17 |
| A | GLY21 |
| A | LYS25 |
| A | ARG265 |
| A | VAL300 |
| A | ARG301 |
| A | TYR331 |
| A | HOH2139 |
| A | HOH2140 |
| A | HOH2143 |
| B | ASN120 |
| B | GOL505 |
| B | GOL506 |
| B | HOH2062 |
| C | LYS449 |
| C | TYR470 |
| C | TYR471 |
| C | LYS474 |
| C | HOH2021 |
| C | HOH2022 |
| C | HOH2023 |
| site_id | BC5 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE I0P D 501 |
| Chain | Residue |
| B | HIS17 |
| B | GLY21 |
| B | HIS22 |
| B | LYS25 |
| B | ARG265 |
| B | VAL300 |
| B | TYR331 |
| B | HOH2120 |
| B | HOH2121 |
| D | LYS449 |
| D | TYR470 |
| D | TYR471 |
| D | LYS474 |
| D | HOH2009 |
| D | HOH2010 |
| D | HOH2011 |
| A | THR116 |
| A | ASN120 |
| A | GOL505 |
| A | GOL506 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 626 |
| Details | Region: {"description":"Histone deacetylase"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"Q13547","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22230954","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4A69","evidenceCode":"ECO:0007744"}]} |
