3S3X
Structure of chicken acid-sensing ion channel 1 AT 3.0 A resolution in complex with psalmotoxin
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005272 | molecular_function | sodium channel activity |
A | 0006814 | biological_process | sodium ion transport |
A | 0015280 | molecular_function | ligand-gated sodium channel activity |
A | 0016020 | cellular_component | membrane |
B | 0005272 | molecular_function | sodium channel activity |
B | 0006814 | biological_process | sodium ion transport |
B | 0015280 | molecular_function | ligand-gated sodium channel activity |
B | 0016020 | cellular_component | membrane |
C | 0005272 | molecular_function | sodium channel activity |
C | 0006814 | biological_process | sodium ion transport |
C | 0015280 | molecular_function | ligand-gated sodium channel activity |
C | 0016020 | cellular_component | membrane |
D | 0005515 | molecular_function | protein binding |
D | 0005576 | cellular_component | extracellular region |
D | 0035821 | biological_process | modulation of process of another organism |
D | 0090729 | molecular_function | toxin activity |
D | 0099106 | molecular_function | ion channel regulator activity |
E | 0005515 | molecular_function | protein binding |
E | 0005576 | cellular_component | extracellular region |
E | 0035821 | biological_process | modulation of process of another organism |
E | 0090729 | molecular_function | toxin activity |
E | 0099106 | molecular_function | ion channel regulator activity |
F | 0005515 | molecular_function | protein binding |
F | 0005576 | cellular_component | extracellular region |
F | 0035821 | biological_process | modulation of process of another organism |
F | 0090729 | molecular_function | toxin activity |
F | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from PROSITE/UniProt
site_id | PS01206 |
Number of Residues | 21 |
Details | ASC Amiloride-sensitive sodium channels signature. YsiTaCridCeTryLVenCnC |
Chain | Residue | Details |
A | TYR304-CYS324 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 9 |
Details | SITE: Key residue for interaction with ASIC1a => ECO:0000269|PubMed:22760635, ECO:0000269|PubMed:22842900, ECO:0000269|PubMed:26248594 |
Chain | Residue | Details |
D | TRP7 | |
D | ARG28 | |
D | PHE30 | |
E | TRP7 | |
E | ARG28 | |
E | PHE30 | |
F | TRP7 | |
F | ARG28 | |
F | PHE30 |
site_id | SWS_FT_FI2 |
Number of Residues | 9 |
Details | SITE: Key residue for interaction with ASIC1a => ECO:0000269|PubMed:21825095, ECO:0000269|PubMed:22760635, ECO:0000269|PubMed:22842900 |
Chain | Residue | Details |
D | TRP24 | |
D | ARG26 | |
D | ARG27 | |
E | TRP24 | |
E | ARG26 | |
E | ARG27 | |
F | TRP24 | |
F | ARG26 | |
F | ARG27 |
site_id | SWS_FT_FI3 |
Number of Residues | 78 |
Details | TRANSMEM: Discontinuously helical |
Chain | Residue | Details |
A | VAL427-PHE453 | |
B | VAL427-PHE453 | |
C | VAL427-PHE453 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | SITE: Important for channel gating |
Chain | Residue | Details |
A | TYR72 | |
A | TRP288 | |
B | TYR72 | |
B | TRP288 | |
C | TYR72 | |
C | TRP288 |
site_id | SWS_FT_FI5 |
Number of Residues | 3 |
Details | SITE: Important for channel desensitizing |
Chain | Residue | Details |
A | GLU80 | |
B | GLU80 | |
C | GLU80 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17882215, ECO:0000269|PubMed:22760635, ECO:0000269|PubMed:22842900 |
Chain | Residue | Details |
A | ASN367 | |
A | ASN394 | |
B | ASN367 | |
B | ASN394 | |
C | ASN367 | |
C | ASN394 |