3QE9

Crystal structure of human exonuclease 1 Exo1 (D173A) in complex with DNA (complex I)

Functional Information from GO Data

Chain	GOid	namespace	contents
Y	0003677	molecular_function	DNA binding
Y	0003824	molecular_function	catalytic activity
Y	0004518	molecular_function	nuclease activity
Y	0016788	molecular_function	hydrolase activity, acting on ester bonds
Y	0035312	molecular_function	5'-3' DNA exonuclease activity
Y	0046872	molecular_function	metal ion binding
Z	0003677	molecular_function	DNA binding
Z	0003824	molecular_function	catalytic activity
Z	0004518	molecular_function	nuclease activity
Z	0016788	molecular_function	hydrolase activity, acting on ester bonds
Z	0035312	molecular_function	5'-3' DNA exonuclease activity
Z	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K Y 353

Chain	Residue
C	DA15
C	HOH92
Y	SER222
Y	SER229
Y	ILE233

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA Y 354

Chain	Residue
Y	HOH427
D	HOH35
Y	ASP152
Y	HOH363
Y	HOH371

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K Z 353

Chain	Residue
A	DT14
Z	SER222
Z	SER229
Z	ILE233
Z	HOH511

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA Z 354

Chain	Residue
Z	ASP152
Z	HOH364
Z	HOH366
Z	HOH378
Z	HOH433
Z	HOH484

---

Functional Information from PROSITE/UniProt

site_id	PS00841
Number of Residues	15
Details	XPG_1 XPG protein signature 1. IKPiLVFDGctLpSK

Chain	Residue	Details
Y	ILE71-LYS85

---

site_id	PS00842
Number of Residues	15
Details	XPG_2 XPG protein signature 2. GVDCLvAPyEADAQL

Chain	Residue	Details
Y	GLY141-LEU155

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	182
Details	Region: {"description":"I-domain"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P39748","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q17RS7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PDB","id":"3QEB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V07","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V08","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V09","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V0A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V0B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V0D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"3QEB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V09","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V0A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V0B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V0D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q58839","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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