3PSE
Structure of a viral OTU domain protease bound to interferon-stimulated gene 15 (ISG15)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0002376 | biological_process | immune system process |
| B | 0002682 | biological_process | regulation of immune system process |
| B | 0003735 | molecular_function | structural constituent of ribosome |
| B | 0005178 | molecular_function | integrin binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0007229 | biological_process | integrin-mediated signaling pathway |
| B | 0009615 | biological_process | response to virus |
| B | 0019941 | biological_process | modification-dependent protein catabolic process |
| B | 0022626 | cellular_component | cytosolic ribosome |
| B | 0030501 | biological_process | positive regulation of bone mineralization |
| B | 0031386 | molecular_function | protein tag activity |
| B | 0031397 | biological_process | negative regulation of protein ubiquitination |
| B | 0032020 | biological_process | ISG15-protein conjugation |
| B | 0032461 | biological_process | positive regulation of protein oligomerization |
| B | 0032649 | biological_process | regulation of type II interferon production |
| B | 0032728 | biological_process | positive regulation of interferon-beta production |
| B | 0032729 | biological_process | positive regulation of type II interferon production |
| B | 0032733 | biological_process | positive regulation of interleukin-10 production |
| B | 0034340 | biological_process | response to type I interferon |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0045071 | biological_process | negative regulation of viral genome replication |
| B | 0045087 | biological_process | innate immune response |
| B | 0045648 | biological_process | positive regulation of erythrocyte differentiation |
| B | 0051240 | biological_process | positive regulation of multicellular organismal process |
| B | 0051607 | biological_process | defense response to virus |
| B | 0060339 | biological_process | negative regulation of type I interferon-mediated signaling pathway |
| B | 0070585 | biological_process | protein localization to mitochondrion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 4LJ B 157 |
| Chain | Residue |
| A | ASP37 |
| A | CYS40 |
| A | TRP99 |
| A | THR150 |
| A | HIS151 |
| B | GLY156 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1344 |
| Chain | Residue |
| B | ASN89 |
| B | GLY91 |
| B | MET150 |
| B | HOH184 |
| A | ASN20 |
| B | ARG87 |
| B | ASN88 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 129 |
| Details | Domain: {"description":"OTU","evidences":[{"source":"PROSITE-ProRule","id":"PRU00139","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 27 |
| Details | Region: {"description":"Essential for the vOTU enzymatic activity","evidences":[{"source":"PubMed","id":"21266548","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For ubiquitin thioesterase activity","evidences":[{"source":"PubMed","id":"21228232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21266548","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For ubiquitin thioesterase activity","evidences":[{"source":"PubMed","id":"21228232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21266548","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18078692","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Interacts with activating enzyme","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"S-nitrosocysteine; alternate","evidences":[{"source":"PubMed","id":"18606809","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
