3PD8

X-ray structure of the ligand-binding core of GluA2 in complex with (S)-7-HPCA at 2.5 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 260

Chain	Residue
A	GLU39
A	LYS42
A	HIS43

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HA7 A 261

Chain	Residue
A	GLY138
A	SER139
A	THR140
A	GLU190
A	MET193
A	HOH270
A	HOH280
A	HOH313
A	HOH322
A	TYR58
A	PRO86
A	LEU87
A	THR88
A	ARG93
A	LEU135

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 262

Chain	Residue
A	PRO102
A	PHE103
A	MET104
A	SER105
A	ASN239
B	SER214
B	LYS215

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACY A 263

Chain	Residue
A	HIS43
A	HOH314

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 260

Chain	Residue
B	GLU39
B	HIS43
C	GLU163
C	CAC263

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 261

Chain	Residue
A	ASP62
A	ASP64
B	HIS20
B	HOH308
B	HOH396

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HA7 B 262

Chain	Residue
B	TYR58
B	PRO86
B	LEU87
B	THR88
B	ARG93
B	LEU135
B	GLY138
B	SER139
B	THR140
B	GLU190
B	HOH267
B	HOH276
B	HOH296
B	HOH311

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 260

Chain	Residue
A	HIS20
C	HIS20
C	GLU27
C	HOH395

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 261

Chain	Residue
B	GLU163
C	GLU39
C	HIS43
C	GLN241
C	HOH358

---

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HA7 C 262

Chain	Residue
C	TYR58
C	PRO86
C	LEU87
C	THR88
C	ARG93
C	LEU135
C	GLY138
C	SER139
C	THR140
C	GLU190
C	MET193
C	HOH272
C	HOH285
C	HOH337

---

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CAC C 263

Chain	Residue
B	GLU39
B	HIS43
B	ZN260
C	ARG160
C	ALA162
C	GLU163
C	SER165
C	PHE167
C	HOH354

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---