3PD8

X-ray structure of the ligand-binding core of GluA2 in complex with (S)-7-HPCA at 2.5 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 260

Chain	Residue
A	GLU39
A	LYS42
A	HIS43

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HA7 A 261

Chain	Residue
A	GLY138
A	SER139
A	THR140
A	GLU190
A	MET193
A	HOH270
A	HOH280
A	HOH313
A	HOH322
A	TYR58
A	PRO86
A	LEU87
A	THR88
A	ARG93
A	LEU135

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 262

Chain	Residue
A	PRO102
A	PHE103
A	MET104
A	SER105
A	ASN239
B	SER214
B	LYS215

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACY A 263

Chain	Residue
A	HIS43
A	HOH314

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 260

Chain	Residue
B	GLU39
B	HIS43
C	GLU163
C	CAC263

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 261

Chain	Residue
A	ASP62
A	ASP64
B	HIS20
B	HOH308
B	HOH396

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HA7 B 262

Chain	Residue
B	TYR58
B	PRO86
B	LEU87
B	THR88
B	ARG93
B	LEU135
B	GLY138
B	SER139
B	THR140
B	GLU190
B	HOH267
B	HOH276
B	HOH296
B	HOH311

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 260

Chain	Residue
A	HIS20
C	HIS20
C	GLU27
C	HOH395

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 261

Chain	Residue
B	GLU163
C	GLU39
C	HIS43
C	GLN241
C	HOH358

---

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HA7 C 262

Chain	Residue
C	TYR58
C	PRO86
C	LEU87
C	THR88
C	ARG93
C	LEU135
C	GLY138
C	SER139
C	THR140
C	GLU190
C	MET193
C	HOH272
C	HOH285
C	HOH337

---

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CAC C 263

Chain	Residue
B	GLU39
B	HIS43
B	ZN260
C	ARG160
C	ALA162
C	GLU163
C	SER165
C	PHE167
C	HOH354

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO86
B	SER139
B	THR140
B	GLU190
C	PRO86
C	THR88
C	ARG93
C	SER139
C	THR140
C	GLU190
A	THR88
A	ARG93
A	SER139
A	THR140
A	GLU190
B	PRO86
B	THR88
B	ARG93

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG61
A	ARG145
A	LYS237
B	ARG61
B	ARG145
B	LYS237
C	ARG61
C	ARG145
C	LYS237

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE118
B	ILE118
C	ILE118

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER147
B	SER147
C	SER147

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER181
B	SER181
C	SER181

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN0
B	ASN0
C	ASN0

---