3OJ4
Crystal structure of the A20 ZnF4, ubiquitin and UbcH5A complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
A | 0000151 | cellular_component | ubiquitin ligase complex |
A | 0000209 | biological_process | protein polyubiquitination |
A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
A | 0016567 | biological_process | protein ubiquitination |
A | 0016740 | molecular_function | transferase activity |
A | 0019787 | molecular_function | ubiquitin-like protein transferase activity |
A | 0030514 | biological_process | negative regulation of BMP signaling pathway |
A | 0031371 | cellular_component | ubiquitin conjugating enzyme complex |
A | 0031398 | biological_process | positive regulation of protein ubiquitination |
A | 0031625 | molecular_function | ubiquitin protein ligase binding |
A | 0032991 | cellular_component | protein-containing complex |
A | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
A | 0061630 | molecular_function | ubiquitin protein ligase activity |
A | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
A | 0070936 | biological_process | protein K48-linked ubiquitination |
A | 1902916 | biological_process | positive regulation of protein polyubiquitination |
A | 1904262 | biological_process | negative regulation of TORC1 signaling |
C | 0003677 | molecular_function | DNA binding |
C | 0008270 | molecular_function | zinc ion binding |
D | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
D | 0000151 | cellular_component | ubiquitin ligase complex |
D | 0000209 | biological_process | protein polyubiquitination |
D | 0004842 | molecular_function | ubiquitin-protein transferase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005524 | molecular_function | ATP binding |
D | 0005634 | cellular_component | nucleus |
D | 0005654 | cellular_component | nucleoplasm |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
D | 0016567 | biological_process | protein ubiquitination |
D | 0016740 | molecular_function | transferase activity |
D | 0019787 | molecular_function | ubiquitin-like protein transferase activity |
D | 0030514 | biological_process | negative regulation of BMP signaling pathway |
D | 0031371 | cellular_component | ubiquitin conjugating enzyme complex |
D | 0031398 | biological_process | positive regulation of protein ubiquitination |
D | 0031625 | molecular_function | ubiquitin protein ligase binding |
D | 0032991 | cellular_component | protein-containing complex |
D | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
D | 0061630 | molecular_function | ubiquitin protein ligase activity |
D | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
D | 0070936 | biological_process | protein K48-linked ubiquitination |
D | 1902916 | biological_process | positive regulation of protein polyubiquitination |
D | 1904262 | biological_process | negative regulation of TORC1 signaling |
F | 0003677 | molecular_function | DNA binding |
F | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 900 |
Chain | Residue |
C | CYS607 |
C | CYS612 |
C | CYS624 |
C | CYS627 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN F 900 |
Chain | Residue |
F | CYS607 |
F | CYS612 |
F | CYS624 |
F | CYS627 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | SITE: Interacts with activating enzyme |
Chain | Residue | Details |
B | ARG54 | |
B | ARG72 | |
E | ARG54 | |
E | ARG72 | |
F | CYS607 | |
F | CYS612 | |
F | CYS624 | |
F | CYS627 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | SITE: Essential for function |
Chain | Residue | Details |
B | HIS68 | |
E | HIS68 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 |
Chain | Residue | Details |
B | SER65 | |
E | SER65 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 |
Chain | Residue | Details |
B | THR66 | |
E | THR66 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742 |
Chain | Residue | Details |
B | GLY76 | |
E | GLY76 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
Chain | Residue | Details |
B | LYS6 | |
E | LYS6 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
Chain | Residue | Details |
B | GLY76 | |
E | GLY76 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 |
Chain | Residue | Details |
B | LYS11 | |
B | LYS48 | |
E | LYS11 | |
E | LYS48 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
Chain | Residue | Details |
B | LYS27 | |
E | LYS27 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 |
Chain | Residue | Details |
B | LYS29 | |
E | LYS29 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
Chain | Residue | Details |
B | LYS33 | |
E | LYS33 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 |
Chain | Residue | Details |
B | LYS63 | |
E | LYS63 |