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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3O0J

PDE4B In complex with ligand an2898

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	HOH78
A	HIS238
A	HIS274
A	ASP275
A	ASP392
A	3OJ485

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 2

Chain	Residue
A	3OJ485
A	HOH495
A	HOH496
A	HOH77
A	HOH78
A	ASP275

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 3OJ A 485

Chain	Residue
A	ZN1
A	MG2
A	HOH78
A	HIS234
A	HIS238
A	ASP275
A	MET347
A	ASP392
A	MET431
A	PHE446
A	HOH496

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 486

Chain	Residue
A	EDO18
A	THR208
A	PHE209
A	ASN325
A	LEU326
A	GLN330

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO A 487

Chain	Residue
A	EDO11
A	ARG210
A	ILE211
A	SER212
A	THR215
A	ASP321
A	ILE322
A	MET324
A	ASN325
A	HOH490

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 5

Chain	Residue
A	SER251
A	ASP256

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 6

Chain	Residue
A	LEU249
A	THR252
A	TRP458
A	ASP465
A	ILE469

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 7

Chain	Residue
A	ASP340
A	LYS349
A	ARG385

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 8

Chain	Residue
A	LEU293
A	TYR297
A	HIS306

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 9

Chain	Residue
A	GLY280
A	VAL281
A	GLU413
A	PHE414
A	GLN417

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 11

Chain	Residue
A	SER212
A	ASP214
A	THR215
A	HIS319
A	EDO487

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 12

Chain	Residue
A	HOH109
A	ARG331
A	ARG335

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 14

Chain	Residue
A	GLU202
A	SER251

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 16

Chain	Residue
A	HOH55
A	LEU250
A	LEU255
A	ALA257
A	VAL258
A	PHE259

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 17

Chain	Residue
A	ARG203
A	ASP204
A	LEU205
A	THR208
A	ASP261
A	ILE264
A	HOH493

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 18

Chain	Residue
A	HOH101
A	THR208
A	ASP261
A	GLN330
A	EDO486

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 19

Chain	Residue
A	GLU300
A	LYS349

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF

Chain	Residue	Details
A	HIS274-PHE285

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000305\|PubMed:15003452, ECO:0007744\|PDB:1ROR

Chain	Residue	Details
A	HIS234

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:15003452, ECO:0000269\|PubMed:15260978, ECO:0007744\|PDB:1ROR, ECO:0007744\|PDB:1TB5

Chain	Residue	Details
A	HIS234
A	GLN443

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:15003452, ECO:0000269\|PubMed:15260978, ECO:0000269\|PubMed:15576036, ECO:0000269\|PubMed:15685167, ECO:0000269\|PubMed:17727341, ECO:0000269\|PubMed:18539455, ECO:0007744\|PDB:1RO6, ECO:0007744\|PDB:1RO9, ECO:0007744\|PDB:1ROR, ECO:0007744\|PDB:1TB5, ECO:0007744\|PDB:1XLX, ECO:0007744\|PDB:1XLZ, ECO:0007744\|PDB:1XM4, ECO:0007744\|PDB:1XM6, ECO:0007744\|PDB:1XMU, ECO:0007744\|PDB:1XMY, ECO:0007744\|PDB:1XN0, ECO:0007744\|PDB:1XOS, ECO:0007744\|PDB:1XOT, ECO:0007744\|PDB:1Y2H, ECO:0007744\|PDB:1Y2J, ECO:0007744\|PDB:2QYL, ECO:0007744\|PDB:3D3P

Chain	Residue	Details
A	HIS238

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:10846163, ECO:0000269\|PubMed:15003452, ECO:0000269\|PubMed:15576036, ECO:0000269\|PubMed:15685167, ECO:0000269\|PubMed:17727341, ECO:0000269\|PubMed:18539455, ECO:0007744\|PDB:1F0J, ECO:0007744\|PDB:1RO6, ECO:0007744\|PDB:1RO9, ECO:0007744\|PDB:1ROR, ECO:0007744\|PDB:1XLX, ECO:0007744\|PDB:1XLZ, ECO:0007744\|PDB:1XM4, ECO:0007744\|PDB:1XM6, ECO:0007744\|PDB:1XMU, ECO:0007744\|PDB:1XMY, ECO:0007744\|PDB:1XN0, ECO:0007744\|PDB:1XOS, ECO:0007744\|PDB:1XOT, ECO:0007744\|PDB:1Y2H, ECO:0007744\|PDB:1Y2J, ECO:0007744\|PDB:2QYL, ECO:0007744\|PDB:3D3P

Chain	Residue	Details
A	HIS274

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:15003452, ECO:0007744\|PDB:1ROR

Chain	Residue	Details
A	ASP275

site_id	SWS_FT_FI6
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:10846163, ECO:0000269\|PubMed:15003452, ECO:0000269\|PubMed:15260978, ECO:0000269\|PubMed:15576036, ECO:0000269\|PubMed:15685167, ECO:0000269\|PubMed:18539455, ECO:0007744\|PDB:1F0J, ECO:0007744\|PDB:1RO6, ECO:0007744\|PDB:1RO9, ECO:0007744\|PDB:1ROR, ECO:0007744\|PDB:1TB5, ECO:0007744\|PDB:1XLX, ECO:0007744\|PDB:1XLZ, ECO:0007744\|PDB:1XM4, ECO:0007744\|PDB:1XM6, ECO:0007744\|PDB:1XMU, ECO:0007744\|PDB:1XMY, ECO:0007744\|PDB:1XN0, ECO:0007744\|PDB:1XOS, ECO:0007744\|PDB:1XOT, ECO:0007744\|PDB:1Y2H, ECO:0007744\|PDB:1Y2J, ECO:0007744\|PDB:3D3P

Chain	Residue	Details
A	ASP392

site_id	SWS_FT_FI7
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305\|PubMed:15003452, ECO:0000305\|PubMed:15260978, ECO:0007744\|PDB:1ROR, ECO:0007744\|PDB:1TB5

Chain	Residue	Details
A	PHE446

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PDB entries from 2024-11-06

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