Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3I5D

Crystal structure of the ATP-gated P2X4 ion channel in the closed, apo state at 3.5 Angstroms (R3)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001614	molecular_function	purinergic nucleotide receptor activity
A	0002135	molecular_function	CTP binding
A	0004931	molecular_function	extracellularly ATP-gated monoatomic cation channel activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005524	molecular_function	ATP binding
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0006816	biological_process	calcium ion transport
A	0007165	biological_process	signal transduction
A	0015267	molecular_function	channel activity
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0017076	molecular_function	purine nucleotide binding
A	0033198	biological_process	response to ATP
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0035381	molecular_function	ATP-gated ion channel activity
A	0035590	biological_process	purinergic nucleotide receptor signaling pathway
A	0060079	biological_process	excitatory postsynaptic potential
A	0070588	biological_process	calcium ion transmembrane transport
A	0098655	biological_process	monoatomic cation transmembrane transport
A	0098794	cellular_component	postsynapse
A	1902495	cellular_component	transmembrane transporter complex
B	0001614	molecular_function	purinergic nucleotide receptor activity
B	0002135	molecular_function	CTP binding
B	0004931	molecular_function	extracellularly ATP-gated monoatomic cation channel activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005524	molecular_function	ATP binding
B	0005764	cellular_component	lysosome
B	0005765	cellular_component	lysosomal membrane
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006812	biological_process	monoatomic cation transport
B	0006816	biological_process	calcium ion transport
B	0007165	biological_process	signal transduction
B	0015267	molecular_function	channel activity
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0017076	molecular_function	purine nucleotide binding
B	0033198	biological_process	response to ATP
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034702	cellular_component	monoatomic ion channel complex
B	0035381	molecular_function	ATP-gated ion channel activity
B	0035590	biological_process	purinergic nucleotide receptor signaling pathway
B	0060079	biological_process	excitatory postsynaptic potential
B	0070588	biological_process	calcium ion transmembrane transport
B	0098655	biological_process	monoatomic cation transmembrane transport
B	0098794	cellular_component	postsynapse
B	1902495	cellular_component	transmembrane transporter complex
C	0001614	molecular_function	purinergic nucleotide receptor activity
C	0002135	molecular_function	CTP binding
C	0004931	molecular_function	extracellularly ATP-gated monoatomic cation channel activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005524	molecular_function	ATP binding
C	0005764	cellular_component	lysosome
C	0005765	cellular_component	lysosomal membrane
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006812	biological_process	monoatomic cation transport
C	0006816	biological_process	calcium ion transport
C	0007165	biological_process	signal transduction
C	0015267	molecular_function	channel activity
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0017076	molecular_function	purine nucleotide binding
C	0033198	biological_process	response to ATP
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034702	cellular_component	monoatomic ion channel complex
C	0035381	molecular_function	ATP-gated ion channel activity
C	0035590	biological_process	purinergic nucleotide receptor signaling pathway
C	0060079	biological_process	excitatory postsynaptic potential
C	0070588	biological_process	calcium ion transmembrane transport
C	0098655	biological_process	monoatomic cation transmembrane transport
C	0098794	cellular_component	postsynapse
C	1902495	cellular_component	transmembrane transporter complex

Functional Information from PROSITE/UniProt

site_id	PS01212
Number of Residues	27
Details	P2X_RECEPTOR ATP P2X receptors signature. GGvMGVqIrWdCDLDmpqswCvPrYtF

Chain	Residue	Details
A	GLY253-PHE279

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	TRANSMEM: Helical => ECO:0000305\|PubMed:28332633, ECO:0007744\|PDB:5WZY

Chain	Residue	Details
A	PHE37-TYR57
A	ALA344-MET364
B	PHE37-TYR57
B	ALA344-MET364
C	PHE37-TYR57
C	ALA344-MET364

site_id	SWS_FT_FI2
Number of Residues	855
Details	TOPO_DOM: Extracellular => ECO:0000305\|PubMed:28332633, ECO:0007744\|PDB:5WZY

Chain	Residue	Details
A	GLN58-GLY343
B	GLN58-GLY343
C	GLN58-GLY343

site_id	SWS_FT_FI3
Number of Residues	21
Details	BINDING: BINDING => ECO:0000269\|PubMed:28332633, ECO:0007744\|PDB:5WZY

Chain	Residue	Details
A	LYS70
B	ARG143
B	THR189
B	ASN296
B	ARG298
B	LYS316
C	LYS70
C	LYS72
C	ARG143
C	THR189
C	ASN296
A	LYS72
C	ARG298
C	LYS316
A	ARG143
A	THR189
A	ASN296
A	ARG298
A	LYS316
B	LYS70
B	LYS72

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:22535247, ECO:0007744\|PDB:4DW1

Chain	Residue	Details
A	LEU191
B	LEU191
C	LEU191

site_id	SWS_FT_FI5
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19641588, ECO:0000312\|PDB:3I5D

Chain	Residue	Details
A	ASN78
B	ASN78
C	ASN78

site_id	SWS_FT_FI6
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19641588, ECO:0000269\|PubMed:22535247, ECO:0007744\|PDB:3H9V, ECO:0007744\|PDB:3I5D, ECO:0007744\|PDB:4DW0, ECO:0007744\|PDB:4DW1, ECO:0007744\|PDB:5WZY

Chain	Residue	Details
A	ASN113
B	ASN113
C	ASN113

site_id	SWS_FT_FI7
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19641588, ECO:0007744\|PDB:3I5D

Chain	Residue	Details
A	ASN187
B	ASN187
C	ASN187

site_id	SWS_FT_FI8
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19641588, ECO:0007744\|PDB:3I5D, ECO:0007744\|PDB:4DW0, ECO:0007744\|PDB:4DW1

Chain	Residue	Details
A	ASN213
B	ASN213
C	ASN213

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)