3EGI
Methyltransferase domain of human trimethylguanosine synthase TGS1 bound to m7GpppA (inactive form)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001510 | biological_process | RNA methylation |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0036261 | biological_process | 7-methylguanosine cap hypermethylation |
| B | 0001510 | biological_process | RNA methylation |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0036261 | biological_process | 7-methylguanosine cap hypermethylation |
| C | 0001510 | biological_process | RNA methylation |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0036261 | biological_process | 7-methylguanosine cap hypermethylation |
| D | 0001510 | biological_process | RNA methylation |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0036261 | biological_process | 7-methylguanosine cap hypermethylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ADP C 1 |
| Chain | Residue |
| C | HOH32 |
| C | LYS724 |
| C | GLY746 |
| C | ASP747 |
| C | PHE748 |
| C | PRO765 |
| C | HOH50 |
| C | HOH157 |
| C | HOH563 |
| C | ALA697 |
| C | PHE698 |
| C | ASP719 |
| C | ILE720 |
| C | ASP721 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP D 2 |
| Chain | Residue |
| D | HOH40 |
| D | HOH55 |
| D | HOH121 |
| D | HOH141 |
| D | HOH569 |
| D | ALA697 |
| D | PHE698 |
| D | GLY700 |
| D | ASP719 |
| D | ILE720 |
| D | ASP721 |
| D | LYS724 |
| D | GLY746 |
| D | ASP747 |
| D | PHE748 |
| D | PRO765 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP A 3 |
| Chain | Residue |
| A | HOH194 |
| A | HOH509 |
| A | HOH576 |
| A | HOH586 |
| A | ALA697 |
| A | PHE698 |
| A | GLY700 |
| A | ASP719 |
| A | ILE720 |
| A | ASP721 |
| A | LYS724 |
| A | GLY746 |
| A | ASP747 |
| A | PHE748 |
| A | PRO765 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP B 4 |
| Chain | Residue |
| B | HOH54 |
| B | HOH83 |
| B | HOH461 |
| B | HOH579 |
| B | HOH619 |
| B | ALA697 |
| B | PHE698 |
| B | GLY700 |
| B | ASP719 |
| B | ILE720 |
| B | ASP721 |
| B | LYS724 |
| B | GLY746 |
| B | ASP747 |
| B | PHE748 |
| B | PRO765 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP719 | |
| B | ASP719 | |
| C | ASP719 | |
| D | ASP719 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19386620 |
| Chain | Residue | Details |
| A | TRP766 | |
| B | TRP766 | |
| C | TRP766 | |
| D | TRP766 |
