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3BJI

Structural Basis of Promiscuous Guanine Nucleotide Exchange by the T-Cell Essential Vav1

Functional Information from GO Data
ChainGOidnamespacecontents
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0035556biological_processintracellular signal transduction
B0005085molecular_functionguanyl-nucleotide exchange factor activity
B0035556biological_processintracellular signal transduction
C0001764biological_processneuron migration
C0001934biological_processpositive regulation of protein phosphorylation
C0003376biological_processsphingosine-1-phosphate receptor signaling pathway
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005802cellular_componenttrans-Golgi network
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005884cellular_componentactin filament
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0005938cellular_componentcell cortex
C0006954biological_processinflammatory response
C0007015biological_processactin filament organization
C0007155biological_processcell adhesion
C0007160biological_processcell-matrix adhesion
C0007163biological_processestablishment or maintenance of cell polarity
C0007264biological_processsmall GTPase-mediated signal transduction
C0008045biological_processmotor neuron axon guidance
C0008360biological_processregulation of cell shape
C0008361biological_processregulation of cell size
C0009611biological_processresponse to wounding
C0009653biological_processanatomical structure morphogenesis
C0010310biological_processregulation of hydrogen peroxide metabolic process
C0010591biological_processregulation of lamellipodium assembly
C0010592biological_processpositive regulation of lamellipodium assembly
C0010595biological_processpositive regulation of endothelial cell migration
C0010764biological_processnegative regulation of fibroblast migration
C0010811biological_processpositive regulation of cell-substrate adhesion
C0016020cellular_componentmembrane
C0016477biological_processcell migration
C0016601biological_processRac protein signal transduction
C0016787molecular_functionhydrolase activity
C0019899molecular_functionenzyme binding
C0019901molecular_functionprotein kinase binding
C0030027cellular_componentlamellipodium
C0030031biological_processcell projection assembly
C0030032biological_processlamellipodium assembly
C0030036biological_processactin cytoskeleton organization
C0030041biological_processactin filament polymerization
C0030334biological_processregulation of cell migration
C0030425cellular_componentdendrite
C0030667cellular_componentsecretory granule membrane
C0030865biological_processcortical cytoskeleton organization
C0031116biological_processpositive regulation of microtubule polymerization
C0031410cellular_componentcytoplasmic vesicle
C0031529biological_processruffle organization
C0031996molecular_functionthioesterase binding
C0032587cellular_componentruffle membrane
C0032707biological_processnegative regulation of interleukin-23 production
C0032956biological_processregulation of actin cytoskeleton organization
C0034446biological_processsubstrate adhesion-dependent cell spreading
C0035025biological_processpositive regulation of Rho protein signal transduction
C0035556biological_processintracellular signal transduction
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0042470cellular_componentmelanosome
C0042554biological_processsuperoxide anion generation
C0042995cellular_componentcell projection
C0043020cellular_componentNADPH oxidase complex
C0043197cellular_componentdendritic spine
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0045428biological_processregulation of nitric oxide biosynthetic process
C0045730biological_processrespiratory burst
C0048012biological_processhepatocyte growth factor receptor signaling pathway
C0048261biological_processnegative regulation of receptor-mediated endocytosis
C0048870biological_processcell motility
C0051022molecular_functionRho GDP-dissociation inhibitor binding
C0051492biological_processregulation of stress fiber assembly
C0051496biological_processpositive regulation of stress fiber assembly
C0051668biological_processlocalization within membrane
C0051894biological_processpositive regulation of focal adhesion assembly
C0055038cellular_componentrecycling endosome membrane
C0060071biological_processWnt signaling pathway, planar cell polarity pathway
C0060263biological_processregulation of respiratory burst
C0060326biological_processcell chemotaxis
C0070062cellular_componentextracellular exosome
C0071526biological_processsemaphorin-plexin signaling pathway
C0090023biological_processpositive regulation of neutrophil chemotaxis
C0097178biological_processruffle assembly
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0101003cellular_componentficolin-1-rich granule membrane
C1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
C1902622biological_processregulation of neutrophil migration
C1903348biological_processpositive regulation of bicellular tight junction assembly
C1990606molecular_functionmembrane scission GTPase motor activity
D0001764biological_processneuron migration
D0001934biological_processpositive regulation of protein phosphorylation
D0003376biological_processsphingosine-1-phosphate receptor signaling pathway
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005789cellular_componentendoplasmic reticulum membrane
D0005802cellular_componenttrans-Golgi network
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005884cellular_componentactin filament
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0005938cellular_componentcell cortex
D0006954biological_processinflammatory response
D0007015biological_processactin filament organization
D0007155biological_processcell adhesion
D0007160biological_processcell-matrix adhesion
D0007163biological_processestablishment or maintenance of cell polarity
D0007264biological_processsmall GTPase-mediated signal transduction
D0008045biological_processmotor neuron axon guidance
D0008360biological_processregulation of cell shape
D0008361biological_processregulation of cell size
D0009611biological_processresponse to wounding
D0009653biological_processanatomical structure morphogenesis
D0010310biological_processregulation of hydrogen peroxide metabolic process
D0010591biological_processregulation of lamellipodium assembly
D0010592biological_processpositive regulation of lamellipodium assembly
D0010595biological_processpositive regulation of endothelial cell migration
D0010764biological_processnegative regulation of fibroblast migration
D0010811biological_processpositive regulation of cell-substrate adhesion
D0016020cellular_componentmembrane
D0016477biological_processcell migration
D0016601biological_processRac protein signal transduction
D0016787molecular_functionhydrolase activity
D0019899molecular_functionenzyme binding
D0019901molecular_functionprotein kinase binding
D0030027cellular_componentlamellipodium
D0030031biological_processcell projection assembly
D0030032biological_processlamellipodium assembly
D0030036biological_processactin cytoskeleton organization
D0030041biological_processactin filament polymerization
D0030334biological_processregulation of cell migration
D0030425cellular_componentdendrite
D0030667cellular_componentsecretory granule membrane
D0030865biological_processcortical cytoskeleton organization
D0031116biological_processpositive regulation of microtubule polymerization
D0031410cellular_componentcytoplasmic vesicle
D0031529biological_processruffle organization
D0031996molecular_functionthioesterase binding
D0032587cellular_componentruffle membrane
D0032707biological_processnegative regulation of interleukin-23 production
D0032956biological_processregulation of actin cytoskeleton organization
D0034446biological_processsubstrate adhesion-dependent cell spreading
D0035025biological_processpositive regulation of Rho protein signal transduction
D0035556biological_processintracellular signal transduction
D0036464cellular_componentcytoplasmic ribonucleoprotein granule
D0042470cellular_componentmelanosome
D0042554biological_processsuperoxide anion generation
D0042995cellular_componentcell projection
D0043020cellular_componentNADPH oxidase complex
D0043197cellular_componentdendritic spine
D0044877molecular_functionprotein-containing complex binding
D0045202cellular_componentsynapse
D0045428biological_processregulation of nitric oxide biosynthetic process
D0045730biological_processrespiratory burst
D0048012biological_processhepatocyte growth factor receptor signaling pathway
D0048261biological_processnegative regulation of receptor-mediated endocytosis
D0048870biological_processcell motility
D0051022molecular_functionRho GDP-dissociation inhibitor binding
D0051492biological_processregulation of stress fiber assembly
D0051496biological_processpositive regulation of stress fiber assembly
D0051668biological_processlocalization within membrane
D0051894biological_processpositive regulation of focal adhesion assembly
D0055038cellular_componentrecycling endosome membrane
D0060071biological_processWnt signaling pathway, planar cell polarity pathway
D0060263biological_processregulation of respiratory burst
D0060326biological_processcell chemotaxis
D0070062cellular_componentextracellular exosome
D0071526biological_processsemaphorin-plexin signaling pathway
D0090023biological_processpositive regulation of neutrophil chemotaxis
D0097178biological_processruffle assembly
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0101003cellular_componentficolin-1-rich granule membrane
D1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
D1902622biological_processregulation of neutrophil migration
D1903348biological_processpositive regulation of bicellular tight junction assembly
D1990606molecular_functionmembrane scission GTPase motor activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 1
ChainResidue
ACYS529
ACYS532
AHIS554
ACYS557

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 2
ChainResidue
BHIS516
BCYS546
BCYS549
BCYS564

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 3
ChainResidue
BCYS532
BHIS554
BCYS557
BCYS529

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 4
ChainResidue
AHIS516
ACYS546
ACYS549
ACYS564

Functional Information from PROSITE/UniProt
site_idPS00479
Number of Residues49
DetailsZF_DAG_PE_1 Zinc finger phorbol-ester/DAG-type signature. HdFqmfsfeetts.CkaCqmlLrgtfyqgyr.ChrCrasaHkeClgrvpp...C
ChainResidueDetails
AHIS516-CYS564

site_idPS00741
Number of Residues26
DetailsDH_1 Dbl homology (DH) domain signature. LrdLLmvPMqrVlKyhLlLqELvkhT
ChainResidueDetails
ALEU322-THR347

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR
ChainResidueDetails
CALA13
CGLY30
CGLY60
DALA13
DGLY30
DGLY60

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR, ECO:0007744|PDB:5HZH
ChainResidueDetails
CLYS116
CALA159
DLYS116
DALA159

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538
ChainResidueDetails
CTYR32
DTYR32

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
CTHR35
DTHR35

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10617634
ChainResidueDetails
CSER71
DSER71

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
CTYR32
DTYR32

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB, and by P.sordellii toxin TcsL; alternate => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
CTHR35
DTHR35

site_idSWS_FT_FI8
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18093184
ChainResidueDetails
CLYS147
DLYS147

site_idSWS_FT_FI9
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23512198
ChainResidueDetails
CLYS166
DLYS166

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
CGLN61

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
DGLN61

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
CALA13

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
DALA13

227111

PDB entries from 2024-11-06

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