2V95

Structure of Corticosteroid-Binding Globulin in complex with Cortisol

Replaces:  2V6D

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004867	molecular_function	serine-type endopeptidase inhibitor activity
A	0005496	molecular_function	steroid binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0008150	biological_process	biological_process
A	0008211	biological_process	glucocorticoid metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE HCY A 1375

Chain	Residue
A	ALA13
A	HOH2124
A	HOH2174
A	PRO14
A	GLN224
A	PHE234
A	ARG252
A	ASP256
A	LYS359
A	TRP362
A	HOH2096

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Functional Information from PROSITE/UniProt

site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. IKFNKPFILlL

Chain	Residue	Details
A	ILE346-LEU356

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:17644521

Chain	Residue	Details
A	GLN224
A	ASP256
A	TRP362

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Conserved cysteine within steroid binding domain

Chain	Residue	Details
A	CYS220

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site_id	SWS_FT_FI3
Number of Residues	5
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN66
A	ASN194
A	ASN230
A	ASN297
A	ASN330

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