2P4S
Structure of Purine Nucleoside Phosphorylase from Anopheles gambiae in complex with DADMe-ImmH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| C | 0006166 | biological_process | purine ribonucleoside salvage |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0016757 | molecular_function | glycosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 B 501 |
| Chain | Residue |
| B | GLY117 |
| B | HOH506 |
| B | SER118 |
| B | HIS149 |
| B | ARG169 |
| B | HIS171 |
| B | ASN200 |
| B | ALA201 |
| B | SER305 |
| B | DIH403 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 C 502 |
| Chain | Residue |
| C | GLY117 |
| C | SER118 |
| C | HIS149 |
| C | ARG169 |
| C | HIS171 |
| C | ASN200 |
| C | ALA201 |
| C | SER305 |
| C | DIH402 |
| C | HOH510 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 A 503 |
| Chain | Residue |
| A | GLY117 |
| A | SER118 |
| A | HIS149 |
| A | ARG169 |
| A | HIS171 |
| A | ASN200 |
| A | ALA201 |
| A | SER305 |
| A | DIH401 |
| A | HOH529 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 504 |
| Chain | Residue |
| A | LEU223 |
| B | LEU223 |
| C | LEU223 |
| C | PHE226 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE DIH A 401 |
| Chain | Residue |
| A | HIS171 |
| A | TYR173 |
| A | ALA201 |
| A | ALA202 |
| A | GLY203 |
| A | PHE285 |
| A | GLU286 |
| A | ILE302 |
| A | GLY303 |
| A | MET304 |
| A | THR327 |
| A | ASN328 |
| A | HIS342 |
| A | ILE345 |
| A | PO4503 |
| A | HOH560 |
| C | PHE244 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE DIH C 402 |
| Chain | Residue |
| B | PHE244 |
| C | SER118 |
| C | HIS171 |
| C | TYR173 |
| C | ALA201 |
| C | ALA202 |
| C | GLY203 |
| C | PHE285 |
| C | GLU286 |
| C | ILE302 |
| C | GLY303 |
| C | MET304 |
| C | THR327 |
| C | ASN328 |
| C | HIS342 |
| C | PO4502 |
| C | HOH606 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE DIH B 403 |
| Chain | Residue |
| A | PHE244 |
| B | HIS171 |
| B | TYR173 |
| B | ALA201 |
| B | ALA202 |
| B | GLY203 |
| B | PHE285 |
| B | GLU286 |
| B | ILE302 |
| B | GLY303 |
| B | MET304 |
| B | THR327 |
| B | ASN328 |
| B | HIS342 |
| B | ILE345 |
| B | PO4501 |
| B | HOH545 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 15 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17918964, ECO:0007744|PDB:2P4S |
| Chain | Residue | Details |
| A | SER118 | |
| B | SER305 | |
| C | SER118 | |
| C | HIS149 | |
| C | ARG169 | |
| C | ALA201 | |
| C | SER305 | |
| A | HIS149 | |
| A | ARG169 | |
| A | ALA201 | |
| A | SER305 | |
| B | SER118 | |
| B | HIS149 | |
| B | ARG169 | |
| B | ALA201 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:17918964, ECO:0007744|PDB:2P4S |
| Chain | Residue | Details |
| A | GLU286 | |
| A | ASN328 | |
| B | GLU286 | |
| B | ASN328 | |
| C | GLU286 | |
| C | ASN328 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ula |
| Chain | Residue | Details |
| A | ASN328 | |
| A | GLU174 | |
| A | HIS171 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ula |
| Chain | Residue | Details |
| B | ASN328 | |
| B | GLU174 | |
| B | HIS171 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ula |
| Chain | Residue | Details |
| C | ASN328 | |
| C | GLU174 | |
| C | HIS171 |
