Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2G1T

A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1501

Chain	Residue
A	ASN368
A	ASP381
A	HOH1512
A	HOH1525
E	1121101

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 1601

Chain	Residue
F	1121201
B	ASN368
B	ASP381
F	HOH268
F	HOH269

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 1701

Chain	Residue
C	ASN368
C	ASP381
C	HOH1795
G	HOH7
G	1121301

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 1801

Chain	Residue
D	ASN368
D	ASP381
D	HOH1928
H	1121401
H	HOH1402

site_id	AC5
Number of Residues	32
Details	BINDING SITE FOR RESIDUE 112 E 1101

Chain	Residue
A	LEU248
A	GLY250
A	GLY251
A	GLN252
A	TYR253
A	GLY254
A	VAL256
A	ALA269
A	LYS271
A	THR315
A	GLU316
A	MET318
A	ASN322
A	ARG367
A	ASN368
A	LEU370
A	ASP381
A	MG1501
A	HOH1512
A	HOH1525
A	HOH1541
A	HOH1560
E	PHE107
E	HOH1103
E	HOH1104
E	HOH1105
E	HOH1107
E	HOH1108
E	HOH1112
E	HOH1113
E	HOH1114
E	HOH1117

site_id	AC6
Number of Residues	32
Details	BINDING SITE FOR RESIDUE 112 F 1201

Chain	Residue
B	LEU248
B	GLY250
B	GLY251
B	GLN252
B	TYR253
B	GLY254
B	VAL256
B	ALA269
B	LYS271
B	THR315
B	GLU316
B	PHE317
B	MET318
B	ASN322
B	ASP363
B	ARG367
B	ASN368
B	LEU370
B	ASP381
B	MG1601
B	HOH1610
B	HOH1637
F	PHE107
F	HOH129
F	HOH200
F	HOH223
F	HOH262
F	HOH268
F	HOH269
F	HOH306
F	HOH536
F	HOH661

site_id	AC7
Number of Residues	31
Details	BINDING SITE FOR RESIDUE 112 G 1301

Chain	Residue
C	ASN368
C	LEU370
C	ASP381
C	MG1701
C	HOH1711
C	HOH1721
C	HOH1795
C	HOH1801
G	HOH7
G	PHE107
G	HOH143
G	HOH323
G	HOH326
G	HOH489
G	HOH586
G	HOH991
C	LEU248
C	GLY250
C	GLY251
C	GLN252
C	TYR253
C	GLY254
C	VAL256
C	ALA269
C	LYS271
C	THR315
C	GLU316
C	PHE317
C	MET318
C	ASN322
C	ARG367

site_id	AC8
Number of Residues	34
Details	BINDING SITE FOR RESIDUE 112 H 1401

Chain	Residue
D	LEU248
D	GLY250
D	GLY251
D	GLN252
D	TYR253
D	GLY254
D	VAL256
D	ALA269
D	LYS271
D	THR315
D	GLU316
D	PHE317
D	MET318
D	ASN322
D	ASP363
D	ARG367
D	ASN368
D	LEU370
D	ASP381
D	MG1801
D	HOH1810
D	HOH1812
D	HOH1928
H	PHE107
H	HOH1402
H	HOH1403
H	HOH1404
H	HOH1405
H	HOH1406
H	HOH1408
H	HOH1410
H	HOH1412
H	HOH1413
H	HOH1415

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGGGQYGEVYeGvwkkyslt..........VAVK

Chain	Residue	Details
A	LEU248-LYS271

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FIHrDLAARNCLV

Chain	Residue	Details
A	PHE359-VAL371

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1004
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	96
Details	Motif: {"description":"Kinase activation loop"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	60
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases","evidences":[{"source":"PubMed","id":"16912036","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P00520","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P42684","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP363
A	ARG367

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASN368
B	ASP363
B	ALA365

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASN368
C	ASP363
C	ALA365

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASN368
D	ASP363
D	ALA365

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP363
B	ARG367

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP363
C	ARG367

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP363
D	ARG367

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP363
A	ALA365

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP363
B	ALA365

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP363
C	ALA365

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP363
D	ALA365

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASN368
A	ASP363
A	ALA365

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)