2AZE
Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005667 | cellular_component | transcription regulator complex |
| A | 0051726 | biological_process | regulation of cell cycle |
| B | 0000978 | molecular_function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| B | 0046983 | molecular_function | protein dimerization activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 73 |
| Details | Region: {"description":"Dimerization","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 116 |
| Details | Region: {"description":"Enhances binding of RB protein to E2F"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Region: {"description":"DCB1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 56 |
| Details | Region: {"description":"DCB2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-methyllysine; by SMYD2","evidences":[{"source":"PubMed","id":"20870719","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
