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1NW3

Structure of the Catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase

Functional Information from GO Data
ChainGOidnamespacecontents
A0031151molecular_functionhistone H3K79 methyltransferase activity
A0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ACT A 600
ChainResidue
ATYR183
AARG231
ATHR235
AHOH1047

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 A 601
ChainResidue
AARG203
AHIS213

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 602
ChainResidue
AARG256
AARG229
AGLN252
AGLU255

site_idAC4
Number of Residues17
DetailsBINDING SITE FOR RESIDUE SAM A 500
ChainResidue
APRO133
AGLY137
AGLU138
ATHR139
AASP161
AGLY163
AGLN168
AVAL169
AGLU186
ALYS187
AGLY221
AASP222
APHE223
APHE239
AASN241
APHE245
AHOH1032

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING:
ChainResidueDetails
ATYR136
APHE159
AGLU186
AASP222

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER297

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER374

219140

PDB entries from 2024-05-01

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