1MZN

CRYSTAL STRUCTURE at 1.9 ANGSTROEMS RESOLUTION OF THE HOMODIMER OF HUMAN RXR ALPHA LIGAND BINDING DOMAIN BOUND TO THE SYNTHETIC AGONIST COMPOUND BMS 649 AND A COACTIVATOR PEPTIDE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003707	molecular_function	nuclear steroid receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
C	0003677	molecular_function	DNA binding
C	0003707	molecular_function	nuclear steroid receptor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription
C	0008270	molecular_function	zinc ion binding
E	0003677	molecular_function	DNA binding
E	0003707	molecular_function	nuclear steroid receptor activity
E	0005634	cellular_component	nucleus
E	0006355	biological_process	regulation of DNA-templated transcription
E	0008270	molecular_function	zinc ion binding
G	0003677	molecular_function	DNA binding
G	0003707	molecular_function	nuclear steroid receptor activity
G	0005634	cellular_component	nucleus
G	0006355	biological_process	regulation of DNA-templated transcription
G	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE BM6 A 200

Chain	Residue
A	ILE268
A	LEU326
A	ALA327
A	CYS432
A	HIS435
A	HOH4020
A	ALA271
A	ALA272
A	GLN275
A	ASN306
A	LEU309
A	ILE310
A	PHE313
A	ARG316

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BM6 C 1200

Chain	Residue
C	ILE1268
C	ALA1271
C	ALA1272
C	GLN1275
C	ASN1306
C	LEU1309
C	ILE1310
C	PHE1313
C	ARG1316
C	LEU1326
C	ALA1327
C	CYS1432
C	HIS1435
C	PHE1439
C	HOH4076

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE BM6 E 2200

Chain	Residue
E	ILE2268
E	ALA2271
E	ALA2272
E	GLN2275
E	ASN2306
E	LEU2309
E	ILE2310
E	PHE2313
E	ARG2316
E	LEU2326
E	ALA2327
E	CYS2432
E	HIS2435
E	HOH4010

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE BM6 G 3200

Chain	Residue
G	ILE3268
G	ALA3271
G	ALA3272
G	GLN3275
G	ASN3306
G	LEU3309
G	ILE3310
G	PHE3313
G	ARG3316
G	LEU3326
G	ALA3327
G	CYS3432
G	HIS3435
G	HOH4057

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Region: {"description":"Required for nuclear export","evidences":[{"source":"PubMed","id":"15509776","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16107141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18800767","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167885","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ACL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FC6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Motif: {"description":"LXXLL motif 2"}

Chain

Residue

Details

---