1K5D

Crystal structure of Ran-GPPNHP-RanBP1-RanGAP complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000054	biological_process	ribosomal subunit export from nucleus
A	0000055	biological_process	ribosomal large subunit export from nucleus
A	0000056	biological_process	ribosomal small subunit export from nucleus
A	0000070	biological_process	mitotic sister chromatid segregation
A	0000166	molecular_function	nucleotide binding
A	0000278	biological_process	mitotic cell cycle
A	0000287	molecular_function	magnesium ion binding
A	0000785	cellular_component	chromatin
A	0001673	cellular_component	male germ cell nucleus
A	0002177	cellular_component	manchette
A	0003682	molecular_function	chromatin binding
A	0003723	molecular_function	RNA binding
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005049	molecular_function	nuclear export signal receptor activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005643	cellular_component	nuclear pore
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005814	cellular_component	centriole
A	0005829	cellular_component	cytosol
A	0006096	biological_process	glycolytic process
A	0006259	biological_process	DNA metabolic process
A	0006606	biological_process	protein import into nucleus
A	0006611	biological_process	protein export from nucleus
A	0006913	biological_process	nucleocytoplasmic transport
A	0007052	biological_process	mitotic spindle organization
A	0007286	biological_process	spermatid development
A	0008104	biological_process	intracellular protein localization
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0016032	biological_process	viral process
A	0016787	molecular_function	hydrolase activity
A	0019003	molecular_function	GDP binding
A	0019904	molecular_function	protein domain specific binding
A	0021766	biological_process	hippocampus development
A	0030036	biological_process	actin cytoskeleton organization
A	0030496	cellular_component	midbody
A	0031503	biological_process	protein-containing complex localization
A	0032991	cellular_component	protein-containing complex
A	0035281	biological_process	pre-miRNA export from nucleus
A	0036126	cellular_component	sperm flagellum
A	0042307	biological_process	positive regulation of protein import into nucleus
A	0042470	cellular_component	melanosome
A	0042565	cellular_component	RNA nuclear export complex
A	0044877	molecular_function	protein-containing complex binding
A	0045296	molecular_function	cadherin binding
A	0045505	molecular_function	dynein intermediate chain binding
A	0046039	biological_process	GTP metabolic process
A	0046872	molecular_function	metal ion binding
A	0046982	molecular_function	protein heterodimerization activity
A	0051301	biological_process	cell division
A	0055037	cellular_component	recycling endosome
A	0061015	biological_process	snRNA import into nucleus
A	0061676	molecular_function	importin-alpha family protein binding
A	0070062	cellular_component	extracellular exosome
A	0070883	molecular_function	pre-miRNA binding
A	0071389	biological_process	cellular response to mineralocorticoid stimulus
A	0090543	cellular_component	Flemming body
A	1902570	biological_process	protein localization to nucleolus
B	0005092	molecular_function	GDP-dissociation inhibitor activity
B	0005096	molecular_function	GTPase activator activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005635	cellular_component	nuclear envelope
B	0005643	cellular_component	nuclear pore
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005829	cellular_component	cytosol
B	0006913	biological_process	nucleocytoplasmic transport
B	0007165	biological_process	signal transduction
B	0031267	molecular_function	small GTPase binding
B	0045296	molecular_function	cadherin binding
B	0046604	biological_process	positive regulation of mitotic centrosome separation
B	0046907	biological_process	intracellular transport
C	0005096	molecular_function	GTPase activator activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006611	biological_process	protein export from nucleus
C	0031267	molecular_function	small GTPase binding
C	0034399	cellular_component	nuclear periphery
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0051168	biological_process	nuclear export
D	0000054	biological_process	ribosomal subunit export from nucleus
D	0000055	biological_process	ribosomal large subunit export from nucleus
D	0000056	biological_process	ribosomal small subunit export from nucleus
D	0000070	biological_process	mitotic sister chromatid segregation
D	0000166	molecular_function	nucleotide binding
D	0000278	biological_process	mitotic cell cycle
D	0000287	molecular_function	magnesium ion binding
D	0000785	cellular_component	chromatin
D	0001673	cellular_component	male germ cell nucleus
D	0002177	cellular_component	manchette
D	0003682	molecular_function	chromatin binding
D	0003723	molecular_function	RNA binding
D	0003924	molecular_function	GTPase activity
D	0003925	molecular_function	G protein activity
D	0005049	molecular_function	nuclear export signal receptor activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005634	cellular_component	nucleus
D	0005635	cellular_component	nuclear envelope
D	0005643	cellular_component	nuclear pore
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005814	cellular_component	centriole
D	0005829	cellular_component	cytosol
D	0006096	biological_process	glycolytic process
D	0006259	biological_process	DNA metabolic process
D	0006606	biological_process	protein import into nucleus
D	0006611	biological_process	protein export from nucleus
D	0006913	biological_process	nucleocytoplasmic transport
D	0007052	biological_process	mitotic spindle organization
D	0007286	biological_process	spermatid development
D	0008104	biological_process	intracellular protein localization
D	0015031	biological_process	protein transport
D	0016020	cellular_component	membrane
D	0016032	biological_process	viral process
D	0016787	molecular_function	hydrolase activity
D	0019003	molecular_function	GDP binding
D	0019904	molecular_function	protein domain specific binding
D	0021766	biological_process	hippocampus development
D	0030036	biological_process	actin cytoskeleton organization
D	0030496	cellular_component	midbody
D	0031503	biological_process	protein-containing complex localization
D	0032991	cellular_component	protein-containing complex
D	0035281	biological_process	pre-miRNA export from nucleus
D	0036126	cellular_component	sperm flagellum
D	0042307	biological_process	positive regulation of protein import into nucleus
D	0042470	cellular_component	melanosome
D	0042565	cellular_component	RNA nuclear export complex
D	0044877	molecular_function	protein-containing complex binding
D	0045296	molecular_function	cadherin binding
D	0045505	molecular_function	dynein intermediate chain binding
D	0046039	biological_process	GTP metabolic process
D	0046872	molecular_function	metal ion binding
D	0046982	molecular_function	protein heterodimerization activity
D	0051301	biological_process	cell division
D	0055037	cellular_component	recycling endosome
D	0061015	biological_process	snRNA import into nucleus
D	0061676	molecular_function	importin-alpha family protein binding
D	0070062	cellular_component	extracellular exosome
D	0070883	molecular_function	pre-miRNA binding
D	0071389	biological_process	cellular response to mineralocorticoid stimulus
D	0090543	cellular_component	Flemming body
D	1902570	biological_process	protein localization to nucleolus
E	0005092	molecular_function	GDP-dissociation inhibitor activity
E	0005096	molecular_function	GTPase activator activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005635	cellular_component	nuclear envelope
E	0005643	cellular_component	nuclear pore
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0006913	biological_process	nucleocytoplasmic transport
E	0007165	biological_process	signal transduction
E	0031267	molecular_function	small GTPase binding
E	0045296	molecular_function	cadherin binding
E	0046604	biological_process	positive regulation of mitotic centrosome separation
E	0046907	biological_process	intracellular transport
F	0005096	molecular_function	GTPase activator activity
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006611	biological_process	protein export from nucleus
F	0031267	molecular_function	small GTPase binding
F	0034399	cellular_component	nuclear periphery
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0051168	biological_process	nuclear export
G	0000054	biological_process	ribosomal subunit export from nucleus
G	0000055	biological_process	ribosomal large subunit export from nucleus
G	0000056	biological_process	ribosomal small subunit export from nucleus
G	0000070	biological_process	mitotic sister chromatid segregation
G	0000166	molecular_function	nucleotide binding
G	0000278	biological_process	mitotic cell cycle
G	0000287	molecular_function	magnesium ion binding
G	0000785	cellular_component	chromatin
G	0001673	cellular_component	male germ cell nucleus
G	0002177	cellular_component	manchette
G	0003682	molecular_function	chromatin binding
G	0003723	molecular_function	RNA binding
G	0003924	molecular_function	GTPase activity
G	0003925	molecular_function	G protein activity
G	0005049	molecular_function	nuclear export signal receptor activity
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005634	cellular_component	nucleus
G	0005635	cellular_component	nuclear envelope
G	0005643	cellular_component	nuclear pore
G	0005654	cellular_component	nucleoplasm
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0005814	cellular_component	centriole
G	0005829	cellular_component	cytosol
G	0006096	biological_process	glycolytic process
G	0006259	biological_process	DNA metabolic process
G	0006606	biological_process	protein import into nucleus
G	0006611	biological_process	protein export from nucleus
G	0006913	biological_process	nucleocytoplasmic transport
G	0007052	biological_process	mitotic spindle organization
G	0007286	biological_process	spermatid development
G	0008104	biological_process	intracellular protein localization
G	0015031	biological_process	protein transport
G	0016020	cellular_component	membrane
G	0016032	biological_process	viral process
G	0016787	molecular_function	hydrolase activity
G	0019003	molecular_function	GDP binding
G	0019904	molecular_function	protein domain specific binding
G	0021766	biological_process	hippocampus development
G	0030036	biological_process	actin cytoskeleton organization
G	0030496	cellular_component	midbody
G	0031503	biological_process	protein-containing complex localization
G	0032991	cellular_component	protein-containing complex
G	0035281	biological_process	pre-miRNA export from nucleus
G	0036126	cellular_component	sperm flagellum
G	0042307	biological_process	positive regulation of protein import into nucleus
G	0042470	cellular_component	melanosome
G	0042565	cellular_component	RNA nuclear export complex
G	0044877	molecular_function	protein-containing complex binding
G	0045296	molecular_function	cadherin binding
G	0045505	molecular_function	dynein intermediate chain binding
G	0046039	biological_process	GTP metabolic process
G	0046872	molecular_function	metal ion binding
G	0046982	molecular_function	protein heterodimerization activity
G	0051301	biological_process	cell division
G	0055037	cellular_component	recycling endosome
G	0061015	biological_process	snRNA import into nucleus
G	0061676	molecular_function	importin-alpha family protein binding
G	0070062	cellular_component	extracellular exosome
G	0070883	molecular_function	pre-miRNA binding
G	0071389	biological_process	cellular response to mineralocorticoid stimulus
G	0090543	cellular_component	Flemming body
G	1902570	biological_process	protein localization to nucleolus
H	0005092	molecular_function	GDP-dissociation inhibitor activity
H	0005096	molecular_function	GTPase activator activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005635	cellular_component	nuclear envelope
H	0005643	cellular_component	nuclear pore
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005829	cellular_component	cytosol
H	0006913	biological_process	nucleocytoplasmic transport
H	0007165	biological_process	signal transduction
H	0031267	molecular_function	small GTPase binding
H	0045296	molecular_function	cadherin binding
H	0046604	biological_process	positive regulation of mitotic centrosome separation
H	0046907	biological_process	intracellular transport
I	0005096	molecular_function	GTPase activator activity
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006611	biological_process	protein export from nucleus
I	0031267	molecular_function	small GTPase binding
I	0034399	cellular_component	nuclear periphery
I	0048471	cellular_component	perinuclear region of cytoplasm
I	0051168	biological_process	nuclear export
J	0000054	biological_process	ribosomal subunit export from nucleus
J	0000055	biological_process	ribosomal large subunit export from nucleus
J	0000056	biological_process	ribosomal small subunit export from nucleus
J	0000070	biological_process	mitotic sister chromatid segregation
J	0000166	molecular_function	nucleotide binding
J	0000278	biological_process	mitotic cell cycle
J	0000287	molecular_function	magnesium ion binding
J	0000785	cellular_component	chromatin
J	0001673	cellular_component	male germ cell nucleus
J	0002177	cellular_component	manchette
J	0003682	molecular_function	chromatin binding
J	0003723	molecular_function	RNA binding
J	0003924	molecular_function	GTPase activity
J	0003925	molecular_function	G protein activity
J	0005049	molecular_function	nuclear export signal receptor activity
J	0005515	molecular_function	protein binding
J	0005525	molecular_function	GTP binding
J	0005634	cellular_component	nucleus
J	0005635	cellular_component	nuclear envelope
J	0005643	cellular_component	nuclear pore
J	0005654	cellular_component	nucleoplasm
J	0005730	cellular_component	nucleolus
J	0005737	cellular_component	cytoplasm
J	0005814	cellular_component	centriole
J	0005829	cellular_component	cytosol
J	0006096	biological_process	glycolytic process
J	0006259	biological_process	DNA metabolic process
J	0006606	biological_process	protein import into nucleus
J	0006611	biological_process	protein export from nucleus
J	0006913	biological_process	nucleocytoplasmic transport
J	0007052	biological_process	mitotic spindle organization
J	0007286	biological_process	spermatid development
J	0008104	biological_process	intracellular protein localization
J	0015031	biological_process	protein transport
J	0016020	cellular_component	membrane
J	0016032	biological_process	viral process
J	0016787	molecular_function	hydrolase activity
J	0019003	molecular_function	GDP binding
J	0019904	molecular_function	protein domain specific binding
J	0021766	biological_process	hippocampus development
J	0030036	biological_process	actin cytoskeleton organization
J	0030496	cellular_component	midbody
J	0031503	biological_process	protein-containing complex localization
J	0032991	cellular_component	protein-containing complex
J	0035281	biological_process	pre-miRNA export from nucleus
J	0036126	cellular_component	sperm flagellum
J	0042307	biological_process	positive regulation of protein import into nucleus
J	0042470	cellular_component	melanosome
J	0042565	cellular_component	RNA nuclear export complex
J	0044877	molecular_function	protein-containing complex binding
J	0045296	molecular_function	cadherin binding
J	0045505	molecular_function	dynein intermediate chain binding
J	0046039	biological_process	GTP metabolic process
J	0046872	molecular_function	metal ion binding
J	0046982	molecular_function	protein heterodimerization activity
J	0051301	biological_process	cell division
J	0055037	cellular_component	recycling endosome
J	0061015	biological_process	snRNA import into nucleus
J	0061676	molecular_function	importin-alpha family protein binding
J	0070062	cellular_component	extracellular exosome
J	0070883	molecular_function	pre-miRNA binding
J	0071389	biological_process	cellular response to mineralocorticoid stimulus
J	0090543	cellular_component	Flemming body
J	1902570	biological_process	protein localization to nucleolus
K	0005092	molecular_function	GDP-dissociation inhibitor activity
K	0005096	molecular_function	GTPase activator activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005635	cellular_component	nuclear envelope
K	0005643	cellular_component	nuclear pore
K	0005737	cellular_component	cytoplasm
K	0005813	cellular_component	centrosome
K	0005829	cellular_component	cytosol
K	0006913	biological_process	nucleocytoplasmic transport
K	0007165	biological_process	signal transduction
K	0031267	molecular_function	small GTPase binding
K	0045296	molecular_function	cadherin binding
K	0046604	biological_process	positive regulation of mitotic centrosome separation
K	0046907	biological_process	intracellular transport
L	0005096	molecular_function	GTPase activator activity
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006611	biological_process	protein export from nucleus
L	0031267	molecular_function	small GTPase binding
L	0034399	cellular_component	nuclear periphery
L	0048471	cellular_component	perinuclear region of cytoplasm
L	0051168	biological_process	nuclear export

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1251

Chain	Residue
A	THR24
A	THR42
A	GNP1250
A	HOH1253
A	HOH1254

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 2251

Chain	Residue
D	HOH2254
D	THR24
D	THR42
D	GNP2250
D	HOH2253

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG G 3251

Chain	Residue
G	THR24
G	THR42
G	GNP3250
G	HOH3253
G	HOH3254

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG J 4251

Chain	Residue
J	THR24
J	THR42
J	GNP4250
J	HOH4253
J	HOH4254

---

site_id	AC5
Number of Residues	24
Details	BINDING SITE FOR RESIDUE GNP A 1250

Chain	Residue
A	GLY20
A	THR21
A	GLY22
A	LYS23
A	THR24
A	THR25
A	GLU36
A	LYS37
A	TYR39
A	THR42
A	GLY68
A	GLN69
A	ASN122
A	LYS123
A	ASP125
A	ILE126
A	SER150
A	ALA151
A	LYS152
A	MG1251
A	HOH1252
A	HOH1253
A	HOH1254
A	HOH1257

---

site_id	AC6
Number of Residues	25
Details	BINDING SITE FOR RESIDUE GNP D 2250

Chain	Residue
D	GLY20
D	THR21
D	GLY22
D	LYS23
D	THR24
D	THR25
D	GLU36
D	LYS37
D	TYR39
D	ALA41
D	THR42
D	GLY68
D	GLN69
D	ASN122
D	LYS123
D	ASP125
D	ILE126
D	SER150
D	ALA151
D	LYS152
D	MG2251
D	HOH2252
D	HOH2253
D	HOH2254
D	HOH2263

---

site_id	AC7
Number of Residues	23
Details	BINDING SITE FOR RESIDUE GNP G 3250

Chain	Residue
G	GLY20
G	THR21
G	GLY22
G	LYS23
G	THR24
G	THR25
G	GLU36
G	LYS37
G	TYR39
G	THR42
G	GLY68
G	GLN69
G	ASN122
G	LYS123
G	ASP125
G	ILE126
G	SER150
G	ALA151
G	LYS152
G	MG3251
G	HOH3252
G	HOH3253
G	HOH3254

---

site_id	AC8
Number of Residues	24
Details	BINDING SITE FOR RESIDUE GNP J 4250

Chain	Residue
J	LYS37
J	TYR39
J	THR42
J	GLY68
J	GLN69
J	ASN122
J	LYS123
J	ASP125
J	ILE126
J	SER150
J	ALA151
J	LYS152
J	MG4251
J	HOH4252
J	HOH4253
J	HOH4254
J	HOH4280
J	GLY20
J	THR21
J	GLY22
J	LYS23
J	THR24
J	THR25
J	GLU36

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Region: {"description":"Switch-I","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	64
Details	Region: {"description":"Switch-II","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10078529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10367892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11832950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18611384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19389996","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19505478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24449914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24915079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26272610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26349033","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28282025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7885480","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K5G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DH9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10078529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10367892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11832950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19389996","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24449914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24915079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26272610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26349033","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28282025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7885480","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DH9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10078529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10367892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11832950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18611384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19389996","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19505478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24449914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24915079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26272610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26349033","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28282025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7885480","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DH9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10078529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10367892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11832950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18611384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19389996","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19505478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24449914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24915079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26272610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26349033","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28282025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7885480","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DH9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10078529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10367892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11832950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18611384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19389996","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19505478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24449914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24915079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26272610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26349033","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28282025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7885480","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1K5G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DH9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Site: {"description":"Essential for GTP hydrolysis","evidences":[{"source":"PubMed","id":"18591255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26272610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8636225","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"31075303","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"29040603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62827","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	552
Details	Domain: {"description":"RanBD1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00164","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P34022","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	100
Details	Repeat: {"description":"LRR 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	108
Details	Repeat: {"description":"LRR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	112
Details	Repeat: {"description":"LRR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	108
Details	Repeat: {"description":"LRR 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	112
Details	Repeat: {"description":"LRR 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	112
Details	Repeat: {"description":"LRR 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	112
Details	Repeat: {"description":"LRR 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	112
Details	Repeat: {"description":"LRR 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	4
Details	Site: {"description":"Critical residue for GTP hydrolysis"}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLN69

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
D	GLN69

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
G	GLN69

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
J	GLN69

---