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1K5D

Crystal structure of Ran-GPPNHP-RanBP1-RanGAP complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000054biological_processribosomal subunit export from nucleus
A0000055biological_processribosomal large subunit export from nucleus
A0000056biological_processribosomal small subunit export from nucleus
A0000070biological_processmitotic sister chromatid segregation
A0000166molecular_functionnucleotide binding
A0000278biological_processmitotic cell cycle
A0000287molecular_functionmagnesium ion binding
A0000785cellular_componentchromatin
A0001673cellular_componentmale germ cell nucleus
A0002177cellular_componentmanchette
A0003682molecular_functionchromatin binding
A0003723molecular_functionRNA binding
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005049molecular_functionnuclear export signal receptor activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005643cellular_componentnuclear pore
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005814cellular_componentcentriole
A0005829cellular_componentcytosol
A0006259biological_processDNA metabolic process
A0006606biological_processprotein import into nucleus
A0006611biological_processprotein export from nucleus
A0006913biological_processnucleocytoplasmic transport
A0007049biological_processcell cycle
A0007052biological_processmitotic spindle organization
A0007286biological_processspermatid development
A0008104biological_processprotein localization
A0014070biological_processresponse to organic cyclic compound
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016032biological_processviral process
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0019904molecular_functionprotein domain specific binding
A0021766biological_processhippocampus development
A0030036biological_processactin cytoskeleton organization
A0030496cellular_componentmidbody
A0031503biological_processprotein-containing complex localization
A0032092biological_processpositive regulation of protein binding
A0032991cellular_componentprotein-containing complex
A0035281biological_processpre-miRNA export from nucleus
A0036126cellular_componentsperm flagellum
A0042307biological_processpositive regulation of protein import into nucleus
A0042470cellular_componentmelanosome
A0042565cellular_componentRNA nuclear export complex
A0044877molecular_functionprotein-containing complex binding
A0045296molecular_functioncadherin binding
A0045505molecular_functiondynein intermediate chain binding
A0046039biological_processGTP metabolic process
A0046872molecular_functionmetal ion binding
A0046982molecular_functionprotein heterodimerization activity
A0051301biological_processcell division
A0055037cellular_componentrecycling endosome
A0061015biological_processsnRNA import into nucleus
A0061676molecular_functionimportin-alpha family protein binding
A0070062cellular_componentextracellular exosome
A0070883molecular_functionpre-miRNA binding
A0071389biological_processcellular response to mineralocorticoid stimulus
A0090543cellular_componentFlemming body
A1902570biological_processprotein localization to nucleolus
B0005092molecular_functionGDP-dissociation inhibitor activity
B0005096molecular_functionGTPase activator activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005643cellular_componentnuclear pore
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0006607biological_processNLS-bearing protein import into nucleus
B0006913biological_processnucleocytoplasmic transport
B0007165biological_processsignal transduction
B0031267molecular_functionsmall GTPase binding
B0045296molecular_functioncadherin binding
B0046604biological_processpositive regulation of mitotic centrosome separation
B0046907biological_processintracellular transport
C0005096molecular_functionGTPase activator activity
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006611biological_processprotein export from nucleus
C0006913biological_processnucleocytoplasmic transport
C0031267molecular_functionsmall GTPase binding
C0034399cellular_componentnuclear periphery
C0048471cellular_componentperinuclear region of cytoplasm
D0000054biological_processribosomal subunit export from nucleus
D0000055biological_processribosomal large subunit export from nucleus
D0000056biological_processribosomal small subunit export from nucleus
D0000070biological_processmitotic sister chromatid segregation
D0000166molecular_functionnucleotide binding
D0000278biological_processmitotic cell cycle
D0000287molecular_functionmagnesium ion binding
D0000785cellular_componentchromatin
D0001673cellular_componentmale germ cell nucleus
D0002177cellular_componentmanchette
D0003682molecular_functionchromatin binding
D0003723molecular_functionRNA binding
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005049molecular_functionnuclear export signal receptor activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005634cellular_componentnucleus
D0005635cellular_componentnuclear envelope
D0005643cellular_componentnuclear pore
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005814cellular_componentcentriole
D0005829cellular_componentcytosol
D0006259biological_processDNA metabolic process
D0006606biological_processprotein import into nucleus
D0006611biological_processprotein export from nucleus
D0006913biological_processnucleocytoplasmic transport
D0007049biological_processcell cycle
D0007052biological_processmitotic spindle organization
D0007286biological_processspermatid development
D0008104biological_processprotein localization
D0014070biological_processresponse to organic cyclic compound
D0015031biological_processprotein transport
D0016020cellular_componentmembrane
D0016032biological_processviral process
D0016787molecular_functionhydrolase activity
D0019003molecular_functionGDP binding
D0019904molecular_functionprotein domain specific binding
D0021766biological_processhippocampus development
D0030036biological_processactin cytoskeleton organization
D0030496cellular_componentmidbody
D0031503biological_processprotein-containing complex localization
D0032092biological_processpositive regulation of protein binding
D0032991cellular_componentprotein-containing complex
D0035281biological_processpre-miRNA export from nucleus
D0036126cellular_componentsperm flagellum
D0042307biological_processpositive regulation of protein import into nucleus
D0042470cellular_componentmelanosome
D0042565cellular_componentRNA nuclear export complex
D0044877molecular_functionprotein-containing complex binding
D0045296molecular_functioncadherin binding
D0045505molecular_functiondynein intermediate chain binding
D0046039biological_processGTP metabolic process
D0046872molecular_functionmetal ion binding
D0046982molecular_functionprotein heterodimerization activity
D0051301biological_processcell division
D0055037cellular_componentrecycling endosome
D0061015biological_processsnRNA import into nucleus
D0061676molecular_functionimportin-alpha family protein binding
D0070062cellular_componentextracellular exosome
D0070883molecular_functionpre-miRNA binding
D0071389biological_processcellular response to mineralocorticoid stimulus
D0090543cellular_componentFlemming body
D1902570biological_processprotein localization to nucleolus
E0005092molecular_functionGDP-dissociation inhibitor activity
E0005096molecular_functionGTPase activator activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005635cellular_componentnuclear envelope
E0005643cellular_componentnuclear pore
E0005737cellular_componentcytoplasm
E0005813cellular_componentcentrosome
E0005829cellular_componentcytosol
E0006607biological_processNLS-bearing protein import into nucleus
E0006913biological_processnucleocytoplasmic transport
E0007165biological_processsignal transduction
E0031267molecular_functionsmall GTPase binding
E0045296molecular_functioncadherin binding
E0046604biological_processpositive regulation of mitotic centrosome separation
E0046907biological_processintracellular transport
F0005096molecular_functionGTPase activator activity
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006611biological_processprotein export from nucleus
F0006913biological_processnucleocytoplasmic transport
F0031267molecular_functionsmall GTPase binding
F0034399cellular_componentnuclear periphery
F0048471cellular_componentperinuclear region of cytoplasm
G0000054biological_processribosomal subunit export from nucleus
G0000055biological_processribosomal large subunit export from nucleus
G0000056biological_processribosomal small subunit export from nucleus
G0000070biological_processmitotic sister chromatid segregation
G0000166molecular_functionnucleotide binding
G0000278biological_processmitotic cell cycle
G0000287molecular_functionmagnesium ion binding
G0000785cellular_componentchromatin
G0001673cellular_componentmale germ cell nucleus
G0002177cellular_componentmanchette
G0003682molecular_functionchromatin binding
G0003723molecular_functionRNA binding
G0003924molecular_functionGTPase activity
G0003925molecular_functionG protein activity
G0005049molecular_functionnuclear export signal receptor activity
G0005515molecular_functionprotein binding
G0005525molecular_functionGTP binding
G0005634cellular_componentnucleus
G0005635cellular_componentnuclear envelope
G0005643cellular_componentnuclear pore
G0005654cellular_componentnucleoplasm
G0005730cellular_componentnucleolus
G0005737cellular_componentcytoplasm
G0005814cellular_componentcentriole
G0005829cellular_componentcytosol
G0006259biological_processDNA metabolic process
G0006606biological_processprotein import into nucleus
G0006611biological_processprotein export from nucleus
G0006913biological_processnucleocytoplasmic transport
G0007049biological_processcell cycle
G0007052biological_processmitotic spindle organization
G0007286biological_processspermatid development
G0008104biological_processprotein localization
G0014070biological_processresponse to organic cyclic compound
G0015031biological_processprotein transport
G0016020cellular_componentmembrane
G0016032biological_processviral process
G0016787molecular_functionhydrolase activity
G0019003molecular_functionGDP binding
G0019904molecular_functionprotein domain specific binding
G0021766biological_processhippocampus development
G0030036biological_processactin cytoskeleton organization
G0030496cellular_componentmidbody
G0031503biological_processprotein-containing complex localization
G0032092biological_processpositive regulation of protein binding
G0032991cellular_componentprotein-containing complex
G0035281biological_processpre-miRNA export from nucleus
G0036126cellular_componentsperm flagellum
G0042307biological_processpositive regulation of protein import into nucleus
G0042470cellular_componentmelanosome
G0042565cellular_componentRNA nuclear export complex
G0044877molecular_functionprotein-containing complex binding
G0045296molecular_functioncadherin binding
G0045505molecular_functiondynein intermediate chain binding
G0046039biological_processGTP metabolic process
G0046872molecular_functionmetal ion binding
G0046982molecular_functionprotein heterodimerization activity
G0051301biological_processcell division
G0055037cellular_componentrecycling endosome
G0061015biological_processsnRNA import into nucleus
G0061676molecular_functionimportin-alpha family protein binding
G0070062cellular_componentextracellular exosome
G0070883molecular_functionpre-miRNA binding
G0071389biological_processcellular response to mineralocorticoid stimulus
G0090543cellular_componentFlemming body
G1902570biological_processprotein localization to nucleolus
H0005092molecular_functionGDP-dissociation inhibitor activity
H0005096molecular_functionGTPase activator activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005635cellular_componentnuclear envelope
H0005643cellular_componentnuclear pore
H0005737cellular_componentcytoplasm
H0005813cellular_componentcentrosome
H0005829cellular_componentcytosol
H0006607biological_processNLS-bearing protein import into nucleus
H0006913biological_processnucleocytoplasmic transport
H0007165biological_processsignal transduction
H0031267molecular_functionsmall GTPase binding
H0045296molecular_functioncadherin binding
H0046604biological_processpositive regulation of mitotic centrosome separation
H0046907biological_processintracellular transport
I0005096molecular_functionGTPase activator activity
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0006611biological_processprotein export from nucleus
I0006913biological_processnucleocytoplasmic transport
I0031267molecular_functionsmall GTPase binding
I0034399cellular_componentnuclear periphery
I0048471cellular_componentperinuclear region of cytoplasm
J0000054biological_processribosomal subunit export from nucleus
J0000055biological_processribosomal large subunit export from nucleus
J0000056biological_processribosomal small subunit export from nucleus
J0000070biological_processmitotic sister chromatid segregation
J0000166molecular_functionnucleotide binding
J0000278biological_processmitotic cell cycle
J0000287molecular_functionmagnesium ion binding
J0000785cellular_componentchromatin
J0001673cellular_componentmale germ cell nucleus
J0002177cellular_componentmanchette
J0003682molecular_functionchromatin binding
J0003723molecular_functionRNA binding
J0003924molecular_functionGTPase activity
J0003925molecular_functionG protein activity
J0005049molecular_functionnuclear export signal receptor activity
J0005515molecular_functionprotein binding
J0005525molecular_functionGTP binding
J0005634cellular_componentnucleus
J0005635cellular_componentnuclear envelope
J0005643cellular_componentnuclear pore
J0005654cellular_componentnucleoplasm
J0005730cellular_componentnucleolus
J0005737cellular_componentcytoplasm
J0005814cellular_componentcentriole
J0005829cellular_componentcytosol
J0006259biological_processDNA metabolic process
J0006606biological_processprotein import into nucleus
J0006611biological_processprotein export from nucleus
J0006913biological_processnucleocytoplasmic transport
J0007049biological_processcell cycle
J0007052biological_processmitotic spindle organization
J0007286biological_processspermatid development
J0008104biological_processprotein localization
J0014070biological_processresponse to organic cyclic compound
J0015031biological_processprotein transport
J0016020cellular_componentmembrane
J0016032biological_processviral process
J0016787molecular_functionhydrolase activity
J0019003molecular_functionGDP binding
J0019904molecular_functionprotein domain specific binding
J0021766biological_processhippocampus development
J0030036biological_processactin cytoskeleton organization
J0030496cellular_componentmidbody
J0031503biological_processprotein-containing complex localization
J0032092biological_processpositive regulation of protein binding
J0032991cellular_componentprotein-containing complex
J0035281biological_processpre-miRNA export from nucleus
J0036126cellular_componentsperm flagellum
J0042307biological_processpositive regulation of protein import into nucleus
J0042470cellular_componentmelanosome
J0042565cellular_componentRNA nuclear export complex
J0044877molecular_functionprotein-containing complex binding
J0045296molecular_functioncadherin binding
J0045505molecular_functiondynein intermediate chain binding
J0046039biological_processGTP metabolic process
J0046872molecular_functionmetal ion binding
J0046982molecular_functionprotein heterodimerization activity
J0051301biological_processcell division
J0055037cellular_componentrecycling endosome
J0061015biological_processsnRNA import into nucleus
J0061676molecular_functionimportin-alpha family protein binding
J0070062cellular_componentextracellular exosome
J0070883molecular_functionpre-miRNA binding
J0071389biological_processcellular response to mineralocorticoid stimulus
J0090543cellular_componentFlemming body
J1902570biological_processprotein localization to nucleolus
K0005092molecular_functionGDP-dissociation inhibitor activity
K0005096molecular_functionGTPase activator activity
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005635cellular_componentnuclear envelope
K0005643cellular_componentnuclear pore
K0005737cellular_componentcytoplasm
K0005813cellular_componentcentrosome
K0005829cellular_componentcytosol
K0006607biological_processNLS-bearing protein import into nucleus
K0006913biological_processnucleocytoplasmic transport
K0007165biological_processsignal transduction
K0031267molecular_functionsmall GTPase binding
K0045296molecular_functioncadherin binding
K0046604biological_processpositive regulation of mitotic centrosome separation
K0046907biological_processintracellular transport
L0005096molecular_functionGTPase activator activity
L0005634cellular_componentnucleus
L0005737cellular_componentcytoplasm
L0005829cellular_componentcytosol
L0006611biological_processprotein export from nucleus
L0006913biological_processnucleocytoplasmic transport
L0031267molecular_functionsmall GTPase binding
L0034399cellular_componentnuclear periphery
L0048471cellular_componentperinuclear region of cytoplasm
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 1251
ChainResidue
ATHR24
ATHR42
AGNP1250
AHOH1253
AHOH1254

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG D 2251
ChainResidue
DHOH2254
DTHR24
DTHR42
DGNP2250
DHOH2253

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG G 3251
ChainResidue
GTHR24
GTHR42
GGNP3250
GHOH3253
GHOH3254

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG J 4251
ChainResidue
JTHR24
JTHR42
JGNP4250
JHOH4253
JHOH4254

site_idAC5
Number of Residues24
DetailsBINDING SITE FOR RESIDUE GNP A 1250
ChainResidue
AGLY20
ATHR21
AGLY22
ALYS23
ATHR24
ATHR25
AGLU36
ALYS37
ATYR39
ATHR42
AGLY68
AGLN69
AASN122
ALYS123
AASP125
AILE126
ASER150
AALA151
ALYS152
AMG1251
AHOH1252
AHOH1253
AHOH1254
AHOH1257

site_idAC6
Number of Residues25
DetailsBINDING SITE FOR RESIDUE GNP D 2250
ChainResidue
DGLY20
DTHR21
DGLY22
DLYS23
DTHR24
DTHR25
DGLU36
DLYS37
DTYR39
DALA41
DTHR42
DGLY68
DGLN69
DASN122
DLYS123
DASP125
DILE126
DSER150
DALA151
DLYS152
DMG2251
DHOH2252
DHOH2253
DHOH2254
DHOH2263

site_idAC7
Number of Residues23
DetailsBINDING SITE FOR RESIDUE GNP G 3250
ChainResidue
GGLY20
GTHR21
GGLY22
GLYS23
GTHR24
GTHR25
GGLU36
GLYS37
GTYR39
GTHR42
GGLY68
GGLN69
GASN122
GLYS123
GASP125
GILE126
GSER150
GALA151
GLYS152
GMG3251
GHOH3252
GHOH3253
GHOH3254

site_idAC8
Number of Residues24
DetailsBINDING SITE FOR RESIDUE GNP J 4250
ChainResidue
JLYS37
JTYR39
JTHR42
JGLY68
JGLN69
JASN122
JLYS123
JASP125
JILE126
JSER150
JALA151
JLYS152
JMG4251
JHOH4252
JHOH4253
JHOH4254
JHOH4280
JGLY20
JTHR21
JGLY22
JLYS23
JTHR24
JTHR25
JGLU36

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsSITE: Critical residue for GTP hydrolysis
ChainResidueDetails
CARG74
FARG74
IARG74
LARG74

site_idSWS_FT_FI2
Number of Residues8
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648
ChainResidueDetails
BTHR13
BTHR18
ETHR13
ETHR18
HTHR13
HTHR18
KTHR13
KTHR18

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
BSER21
ESER21
HSER21
KSER21

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
BSER60
ESER60
HSER60
KSER60

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P34022
ChainResidueDetails
BLYS150
ELYS150
HLYS150
KLYS150

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS183
ELYS183
HLYS183
KLYS183

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER188
ESER188
HSER188
KSER188

site_idSWS_FT_FI8
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS190
DTHR24
ELYS190
JTHR24
HLYS190
KLYS190

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:31075303
ChainResidueDetails
ALYS37
DLYS37
GLYS37
JLYS37

site_idSWS_FT_FI10
Number of Residues8
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS60
ALYS99
DLYS60
DLYS99
GLYS60
GLYS99
JLYS60
JLYS99

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS71
DLYS71
GLYS71
JLYS71

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:29040603
ChainResidueDetails
ALYS134
DLYS134
GLYS134
JLYS134

site_idSWS_FT_FI13
Number of Residues4
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62827
ChainResidueDetails
ALYS159
DLYS159
GLYS159
JLYS159

site_idSWS_FT_FI14
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
ChainResidueDetails
ALYS71
DLYS71
GLYS71
JLYS71

site_idSWS_FT_FI15
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS152
DLYS152
GLYS152
JLYS152

218853

PDB entries from 2024-04-24

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