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1FQV

Insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex

Functional Information from GO Data
ChainGOidnamespacecontents
B0000082biological_processG1/S transition of mitotic cell cycle
B0000151cellular_componentubiquitin ligase complex
B0000209biological_processprotein polyubiquitination
B0000785cellular_componentchromatin
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0006338biological_processchromatin remodeling
B0006355biological_processregulation of DNA-templated transcription
B0006511biological_processubiquitin-dependent protein catabolic process
B0006879biological_processintracellular iron ion homeostasis
B0007346biological_processregulation of mitotic cell cycle
B0008013molecular_functionbeta-catenin binding
B0010564biological_processregulation of cell cycle process
B0010824biological_processregulation of centrosome duplication
B0014033biological_processneural crest cell differentiation
B0016567biological_processprotein ubiquitination
B0019005cellular_componentSCF ubiquitin ligase complex
B0019904molecular_functionprotein domain specific binding
B0030510biological_processregulation of BMP signaling pathway
B0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B0031467cellular_componentCul7-RING ubiquitin ligase complex
B0031507biological_processheterochromatin formation
B0031519cellular_componentPcG protein complex
B0032006biological_processregulation of TOR signaling
B0035102cellular_componentPRC1 complex
B0042752biological_processregulation of circadian rhythm
B0042981biological_processregulation of apoptotic process
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0045892biological_processnegative regulation of DNA-templated transcription
B0050727biological_processregulation of inflammatory response
B0051124biological_processsynaptic assembly at neuromuscular junction
B0051298biological_processcentrosome duplication
B0051457biological_processmaintenance of protein location in nucleus
B0051726biological_processregulation of cell cycle
B0060173biological_processlimb development
B0060271biological_processcilium assembly
B0070936biological_processprotein K48-linked ubiquitination
B0097602molecular_functioncullin family protein binding
B0140677molecular_functionmolecular function activator activity
B0160072molecular_functionubiquitin ligase complex scaffold activity
B1901524biological_processregulation of mitophagy
B1904415biological_processregulation of xenophagy
B1990444molecular_functionF-box domain binding
B1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
B1990757molecular_functionubiquitin ligase activator activity
B2000001biological_processregulation of DNA damage checkpoint
D0000082biological_processG1/S transition of mitotic cell cycle
D0000151cellular_componentubiquitin ligase complex
D0000209biological_processprotein polyubiquitination
D0000785cellular_componentchromatin
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0006338biological_processchromatin remodeling
D0006355biological_processregulation of DNA-templated transcription
D0006511biological_processubiquitin-dependent protein catabolic process
D0006879biological_processintracellular iron ion homeostasis
D0007346biological_processregulation of mitotic cell cycle
D0008013molecular_functionbeta-catenin binding
D0010564biological_processregulation of cell cycle process
D0010824biological_processregulation of centrosome duplication
D0014033biological_processneural crest cell differentiation
D0016567biological_processprotein ubiquitination
D0019005cellular_componentSCF ubiquitin ligase complex
D0019904molecular_functionprotein domain specific binding
D0030510biological_processregulation of BMP signaling pathway
D0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D0031467cellular_componentCul7-RING ubiquitin ligase complex
D0031507biological_processheterochromatin formation
D0031519cellular_componentPcG protein complex
D0032006biological_processregulation of TOR signaling
D0035102cellular_componentPRC1 complex
D0042752biological_processregulation of circadian rhythm
D0042981biological_processregulation of apoptotic process
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0045892biological_processnegative regulation of DNA-templated transcription
D0050727biological_processregulation of inflammatory response
D0051124biological_processsynaptic assembly at neuromuscular junction
D0051298biological_processcentrosome duplication
D0051457biological_processmaintenance of protein location in nucleus
D0051726biological_processregulation of cell cycle
D0060173biological_processlimb development
D0060271biological_processcilium assembly
D0070936biological_processprotein K48-linked ubiquitination
D0097602molecular_functioncullin family protein binding
D0140677molecular_functionmolecular function activator activity
D0160072molecular_functionubiquitin ligase complex scaffold activity
D1901524biological_processregulation of mitophagy
D1904415biological_processregulation of xenophagy
D1990444molecular_functionF-box domain binding
D1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
D1990757molecular_functionubiquitin ligase activator activity
D2000001biological_processregulation of DNA damage checkpoint
F0000082biological_processG1/S transition of mitotic cell cycle
F0000151cellular_componentubiquitin ligase complex
F0000209biological_processprotein polyubiquitination
F0000785cellular_componentchromatin
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005813cellular_componentcentrosome
F0005829cellular_componentcytosol
F0006338biological_processchromatin remodeling
F0006355biological_processregulation of DNA-templated transcription
F0006511biological_processubiquitin-dependent protein catabolic process
F0006879biological_processintracellular iron ion homeostasis
F0007346biological_processregulation of mitotic cell cycle
F0008013molecular_functionbeta-catenin binding
F0010564biological_processregulation of cell cycle process
F0010824biological_processregulation of centrosome duplication
F0014033biological_processneural crest cell differentiation
F0016567biological_processprotein ubiquitination
F0019005cellular_componentSCF ubiquitin ligase complex
F0019904molecular_functionprotein domain specific binding
F0030510biological_processregulation of BMP signaling pathway
F0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
F0031467cellular_componentCul7-RING ubiquitin ligase complex
F0031507biological_processheterochromatin formation
F0031519cellular_componentPcG protein complex
F0032006biological_processregulation of TOR signaling
F0035102cellular_componentPRC1 complex
F0042752biological_processregulation of circadian rhythm
F0042981biological_processregulation of apoptotic process
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0045892biological_processnegative regulation of DNA-templated transcription
F0050727biological_processregulation of inflammatory response
F0051124biological_processsynaptic assembly at neuromuscular junction
F0051298biological_processcentrosome duplication
F0051457biological_processmaintenance of protein location in nucleus
F0051726biological_processregulation of cell cycle
F0060173biological_processlimb development
F0060271biological_processcilium assembly
F0070936biological_processprotein K48-linked ubiquitination
F0097602molecular_functioncullin family protein binding
F0140677molecular_functionmolecular function activator activity
F0160072molecular_functionubiquitin ligase complex scaffold activity
F1901524biological_processregulation of mitophagy
F1904415biological_processregulation of xenophagy
F1990444molecular_functionF-box domain binding
F1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
F1990757molecular_functionubiquitin ligase activator activity
F2000001biological_processregulation of DNA damage checkpoint
H0000082biological_processG1/S transition of mitotic cell cycle
H0000151cellular_componentubiquitin ligase complex
H0000209biological_processprotein polyubiquitination
H0000785cellular_componentchromatin
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005813cellular_componentcentrosome
H0005829cellular_componentcytosol
H0006338biological_processchromatin remodeling
H0006355biological_processregulation of DNA-templated transcription
H0006511biological_processubiquitin-dependent protein catabolic process
H0006879biological_processintracellular iron ion homeostasis
H0007346biological_processregulation of mitotic cell cycle
H0008013molecular_functionbeta-catenin binding
H0010564biological_processregulation of cell cycle process
H0010824biological_processregulation of centrosome duplication
H0014033biological_processneural crest cell differentiation
H0016567biological_processprotein ubiquitination
H0019005cellular_componentSCF ubiquitin ligase complex
H0019904molecular_functionprotein domain specific binding
H0030510biological_processregulation of BMP signaling pathway
H0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
H0031467cellular_componentCul7-RING ubiquitin ligase complex
H0031507biological_processheterochromatin formation
H0031519cellular_componentPcG protein complex
H0032006biological_processregulation of TOR signaling
H0035102cellular_componentPRC1 complex
H0042752biological_processregulation of circadian rhythm
H0042981biological_processregulation of apoptotic process
H0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
H0045892biological_processnegative regulation of DNA-templated transcription
H0050727biological_processregulation of inflammatory response
H0051124biological_processsynaptic assembly at neuromuscular junction
H0051298biological_processcentrosome duplication
H0051457biological_processmaintenance of protein location in nucleus
H0051726biological_processregulation of cell cycle
H0060173biological_processlimb development
H0060271biological_processcilium assembly
H0070936biological_processprotein K48-linked ubiquitination
H0097602molecular_functioncullin family protein binding
H0140677molecular_functionmolecular function activator activity
H0160072molecular_functionubiquitin ligase complex scaffold activity
H1901524biological_processregulation of mitophagy
H1904415biological_processregulation of xenophagy
H1990444molecular_functionF-box domain binding
H1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
H1990757molecular_functionubiquitin ligase activator activity
H2000001biological_processregulation of DNA damage checkpoint
J0000082biological_processG1/S transition of mitotic cell cycle
J0000151cellular_componentubiquitin ligase complex
J0000209biological_processprotein polyubiquitination
J0000785cellular_componentchromatin
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005813cellular_componentcentrosome
J0005829cellular_componentcytosol
J0006338biological_processchromatin remodeling
J0006355biological_processregulation of DNA-templated transcription
J0006511biological_processubiquitin-dependent protein catabolic process
J0006879biological_processintracellular iron ion homeostasis
J0007346biological_processregulation of mitotic cell cycle
J0008013molecular_functionbeta-catenin binding
J0010564biological_processregulation of cell cycle process
J0010824biological_processregulation of centrosome duplication
J0014033biological_processneural crest cell differentiation
J0016567biological_processprotein ubiquitination
J0019005cellular_componentSCF ubiquitin ligase complex
J0019904molecular_functionprotein domain specific binding
J0030510biological_processregulation of BMP signaling pathway
J0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
J0031467cellular_componentCul7-RING ubiquitin ligase complex
J0031507biological_processheterochromatin formation
J0031519cellular_componentPcG protein complex
J0032006biological_processregulation of TOR signaling
J0035102cellular_componentPRC1 complex
J0042752biological_processregulation of circadian rhythm
J0042981biological_processregulation of apoptotic process
J0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
J0045892biological_processnegative regulation of DNA-templated transcription
J0050727biological_processregulation of inflammatory response
J0051124biological_processsynaptic assembly at neuromuscular junction
J0051298biological_processcentrosome duplication
J0051457biological_processmaintenance of protein location in nucleus
J0051726biological_processregulation of cell cycle
J0060173biological_processlimb development
J0060271biological_processcilium assembly
J0070936biological_processprotein K48-linked ubiquitination
J0097602molecular_functioncullin family protein binding
J0140677molecular_functionmolecular function activator activity
J0160072molecular_functionubiquitin ligase complex scaffold activity
J1901524biological_processregulation of mitophagy
J1904415biological_processregulation of xenophagy
J1990444molecular_functionF-box domain binding
J1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
J1990757molecular_functionubiquitin ligase activator activity
J2000001biological_processregulation of DNA damage checkpoint
L0000082biological_processG1/S transition of mitotic cell cycle
L0000151cellular_componentubiquitin ligase complex
L0000209biological_processprotein polyubiquitination
L0000785cellular_componentchromatin
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005737cellular_componentcytoplasm
L0005813cellular_componentcentrosome
L0005829cellular_componentcytosol
L0006338biological_processchromatin remodeling
L0006355biological_processregulation of DNA-templated transcription
L0006511biological_processubiquitin-dependent protein catabolic process
L0006879biological_processintracellular iron ion homeostasis
L0007346biological_processregulation of mitotic cell cycle
L0008013molecular_functionbeta-catenin binding
L0010564biological_processregulation of cell cycle process
L0010824biological_processregulation of centrosome duplication
L0014033biological_processneural crest cell differentiation
L0016567biological_processprotein ubiquitination
L0019005cellular_componentSCF ubiquitin ligase complex
L0019904molecular_functionprotein domain specific binding
L0030510biological_processregulation of BMP signaling pathway
L0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
L0031467cellular_componentCul7-RING ubiquitin ligase complex
L0031507biological_processheterochromatin formation
L0031519cellular_componentPcG protein complex
L0032006biological_processregulation of TOR signaling
L0035102cellular_componentPRC1 complex
L0042752biological_processregulation of circadian rhythm
L0042981biological_processregulation of apoptotic process
L0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
L0045892biological_processnegative regulation of DNA-templated transcription
L0050727biological_processregulation of inflammatory response
L0051124biological_processsynaptic assembly at neuromuscular junction
L0051298biological_processcentrosome duplication
L0051457biological_processmaintenance of protein location in nucleus
L0051726biological_processregulation of cell cycle
L0060173biological_processlimb development
L0060271biological_processcilium assembly
L0070936biological_processprotein K48-linked ubiquitination
L0097602molecular_functioncullin family protein binding
L0140677molecular_functionmolecular function activator activity
L0160072molecular_functionubiquitin ligase complex scaffold activity
L1901524biological_processregulation of mitophagy
L1904415biological_processregulation of xenophagy
L1990444molecular_functionF-box domain binding
L1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
L1990757molecular_functionubiquitin ligase activator activity
L2000001biological_processregulation of DNA damage checkpoint
N0000082biological_processG1/S transition of mitotic cell cycle
N0000151cellular_componentubiquitin ligase complex
N0000209biological_processprotein polyubiquitination
N0000785cellular_componentchromatin
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005654cellular_componentnucleoplasm
N0005737cellular_componentcytoplasm
N0005813cellular_componentcentrosome
N0005829cellular_componentcytosol
N0006338biological_processchromatin remodeling
N0006355biological_processregulation of DNA-templated transcription
N0006511biological_processubiquitin-dependent protein catabolic process
N0006879biological_processintracellular iron ion homeostasis
N0007346biological_processregulation of mitotic cell cycle
N0008013molecular_functionbeta-catenin binding
N0010564biological_processregulation of cell cycle process
N0010824biological_processregulation of centrosome duplication
N0014033biological_processneural crest cell differentiation
N0016567biological_processprotein ubiquitination
N0019005cellular_componentSCF ubiquitin ligase complex
N0019904molecular_functionprotein domain specific binding
N0030510biological_processregulation of BMP signaling pathway
N0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
N0031467cellular_componentCul7-RING ubiquitin ligase complex
N0031507biological_processheterochromatin formation
N0031519cellular_componentPcG protein complex
N0032006biological_processregulation of TOR signaling
N0035102cellular_componentPRC1 complex
N0042752biological_processregulation of circadian rhythm
N0042981biological_processregulation of apoptotic process
N0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
N0045892biological_processnegative regulation of DNA-templated transcription
N0050727biological_processregulation of inflammatory response
N0051124biological_processsynaptic assembly at neuromuscular junction
N0051298biological_processcentrosome duplication
N0051457biological_processmaintenance of protein location in nucleus
N0051726biological_processregulation of cell cycle
N0060173biological_processlimb development
N0060271biological_processcilium assembly
N0070936biological_processprotein K48-linked ubiquitination
N0097602molecular_functioncullin family protein binding
N0140677molecular_functionmolecular function activator activity
N0160072molecular_functionubiquitin ligase complex scaffold activity
N1901524biological_processregulation of mitophagy
N1904415biological_processregulation of xenophagy
N1990444molecular_functionF-box domain binding
N1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
N1990757molecular_functionubiquitin ligase activator activity
N2000001biological_processregulation of DNA damage checkpoint
P0000082biological_processG1/S transition of mitotic cell cycle
P0000151cellular_componentubiquitin ligase complex
P0000209biological_processprotein polyubiquitination
P0000785cellular_componentchromatin
P0005515molecular_functionprotein binding
P0005634cellular_componentnucleus
P0005654cellular_componentnucleoplasm
P0005737cellular_componentcytoplasm
P0005813cellular_componentcentrosome
P0005829cellular_componentcytosol
P0006338biological_processchromatin remodeling
P0006355biological_processregulation of DNA-templated transcription
P0006511biological_processubiquitin-dependent protein catabolic process
P0006879biological_processintracellular iron ion homeostasis
P0007346biological_processregulation of mitotic cell cycle
P0008013molecular_functionbeta-catenin binding
P0010564biological_processregulation of cell cycle process
P0010824biological_processregulation of centrosome duplication
P0014033biological_processneural crest cell differentiation
P0016567biological_processprotein ubiquitination
P0019005cellular_componentSCF ubiquitin ligase complex
P0019904molecular_functionprotein domain specific binding
P0030510biological_processregulation of BMP signaling pathway
P0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
P0031467cellular_componentCul7-RING ubiquitin ligase complex
P0031507biological_processheterochromatin formation
P0031519cellular_componentPcG protein complex
P0032006biological_processregulation of TOR signaling
P0035102cellular_componentPRC1 complex
P0042752biological_processregulation of circadian rhythm
P0042981biological_processregulation of apoptotic process
P0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
P0045892biological_processnegative regulation of DNA-templated transcription
P0050727biological_processregulation of inflammatory response
P0051124biological_processsynaptic assembly at neuromuscular junction
P0051298biological_processcentrosome duplication
P0051457biological_processmaintenance of protein location in nucleus
P0051726biological_processregulation of cell cycle
P0060173biological_processlimb development
P0060271biological_processcilium assembly
P0070936biological_processprotein K48-linked ubiquitination
P0097602molecular_functioncullin family protein binding
P0140677molecular_functionmolecular function activator activity
P0160072molecular_functionubiquitin ligase complex scaffold activity
P1901524biological_processregulation of mitophagy
P1904415biological_processregulation of xenophagy
P1990444molecular_functionF-box domain binding
P1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
P1990757molecular_functionubiquitin ligase activator activity
P2000001biological_processregulation of DNA damage checkpoint
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues200
DetailsRepeat: {"description":"LRR 1","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues216
DetailsRepeat: {"description":"LRR 2","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues192
DetailsRepeat: {"description":"LRR 3","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues176
DetailsRepeat: {"description":"LRR 4","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues208
DetailsRepeat: {"description":"LRR 5","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues176
DetailsRepeat: {"description":"LRR 6","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues168
DetailsRepeat: {"description":"LRR 7","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues176
DetailsRepeat: {"description":"LRR 8","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues152
DetailsRepeat: {"description":"LRR 9","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues168
DetailsRepeat: {"description":"LRR 10","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues8
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues16
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

245663

PDB entries from 2025-12-03

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