Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1FQV

Insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000209	biological_process	protein polyubiquitination
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005829	cellular_component	cytosol
B	0006338	biological_process	chromatin remodeling
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0006513	biological_process	protein monoubiquitination
B	0008013	molecular_function	beta-catenin binding
B	0016567	biological_process	protein ubiquitination
B	0019005	cellular_component	SCF ubiquitin ligase complex
B	0019904	molecular_function	protein domain specific binding
B	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
B	0031519	cellular_component	PcG protein complex
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0051457	biological_process	maintenance of protein location in nucleus
B	0070936	biological_process	protein K48-linked ubiquitination
B	0097602	molecular_function	cullin family protein binding
B	0140677	molecular_function	molecular function activator activity
B	0160072	molecular_function	ubiquitin ligase complex scaffold activity
B	1990444	molecular_function	F-box domain binding
B	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
B	1990757	molecular_function	ubiquitin ligase activator activity
D	0000209	biological_process	protein polyubiquitination
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0006338	biological_process	chromatin remodeling
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006513	biological_process	protein monoubiquitination
D	0008013	molecular_function	beta-catenin binding
D	0016567	biological_process	protein ubiquitination
D	0019005	cellular_component	SCF ubiquitin ligase complex
D	0019904	molecular_function	protein domain specific binding
D	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
D	0031519	cellular_component	PcG protein complex
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051457	biological_process	maintenance of protein location in nucleus
D	0070936	biological_process	protein K48-linked ubiquitination
D	0097602	molecular_function	cullin family protein binding
D	0140677	molecular_function	molecular function activator activity
D	0160072	molecular_function	ubiquitin ligase complex scaffold activity
D	1990444	molecular_function	F-box domain binding
D	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
D	1990757	molecular_function	ubiquitin ligase activator activity
F	0000209	biological_process	protein polyubiquitination
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005829	cellular_component	cytosol
F	0006338	biological_process	chromatin remodeling
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0006513	biological_process	protein monoubiquitination
F	0008013	molecular_function	beta-catenin binding
F	0016567	biological_process	protein ubiquitination
F	0019005	cellular_component	SCF ubiquitin ligase complex
F	0019904	molecular_function	protein domain specific binding
F	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
F	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
F	0031519	cellular_component	PcG protein complex
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0051457	biological_process	maintenance of protein location in nucleus
F	0070936	biological_process	protein K48-linked ubiquitination
F	0097602	molecular_function	cullin family protein binding
F	0140677	molecular_function	molecular function activator activity
F	0160072	molecular_function	ubiquitin ligase complex scaffold activity
F	1990444	molecular_function	F-box domain binding
F	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
F	1990757	molecular_function	ubiquitin ligase activator activity
H	0000209	biological_process	protein polyubiquitination
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005829	cellular_component	cytosol
H	0006338	biological_process	chromatin remodeling
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0006513	biological_process	protein monoubiquitination
H	0008013	molecular_function	beta-catenin binding
H	0016567	biological_process	protein ubiquitination
H	0019005	cellular_component	SCF ubiquitin ligase complex
H	0019904	molecular_function	protein domain specific binding
H	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
H	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
H	0031519	cellular_component	PcG protein complex
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0051457	biological_process	maintenance of protein location in nucleus
H	0070936	biological_process	protein K48-linked ubiquitination
H	0097602	molecular_function	cullin family protein binding
H	0140677	molecular_function	molecular function activator activity
H	0160072	molecular_function	ubiquitin ligase complex scaffold activity
H	1990444	molecular_function	F-box domain binding
H	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
H	1990757	molecular_function	ubiquitin ligase activator activity
J	0000209	biological_process	protein polyubiquitination
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005813	cellular_component	centrosome
J	0005829	cellular_component	cytosol
J	0006338	biological_process	chromatin remodeling
J	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0006513	biological_process	protein monoubiquitination
J	0008013	molecular_function	beta-catenin binding
J	0016567	biological_process	protein ubiquitination
J	0019005	cellular_component	SCF ubiquitin ligase complex
J	0019904	molecular_function	protein domain specific binding
J	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
J	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
J	0031519	cellular_component	PcG protein complex
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0051457	biological_process	maintenance of protein location in nucleus
J	0070936	biological_process	protein K48-linked ubiquitination
J	0097602	molecular_function	cullin family protein binding
J	0140677	molecular_function	molecular function activator activity
J	0160072	molecular_function	ubiquitin ligase complex scaffold activity
J	1990444	molecular_function	F-box domain binding
J	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
J	1990757	molecular_function	ubiquitin ligase activator activity
L	0000209	biological_process	protein polyubiquitination
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005813	cellular_component	centrosome
L	0005829	cellular_component	cytosol
L	0006338	biological_process	chromatin remodeling
L	0006511	biological_process	ubiquitin-dependent protein catabolic process
L	0006513	biological_process	protein monoubiquitination
L	0008013	molecular_function	beta-catenin binding
L	0016567	biological_process	protein ubiquitination
L	0019005	cellular_component	SCF ubiquitin ligase complex
L	0019904	molecular_function	protein domain specific binding
L	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
L	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
L	0031519	cellular_component	PcG protein complex
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0051457	biological_process	maintenance of protein location in nucleus
L	0070936	biological_process	protein K48-linked ubiquitination
L	0097602	molecular_function	cullin family protein binding
L	0140677	molecular_function	molecular function activator activity
L	0160072	molecular_function	ubiquitin ligase complex scaffold activity
L	1990444	molecular_function	F-box domain binding
L	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
L	1990757	molecular_function	ubiquitin ligase activator activity
N	0000209	biological_process	protein polyubiquitination
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005813	cellular_component	centrosome
N	0005829	cellular_component	cytosol
N	0006338	biological_process	chromatin remodeling
N	0006511	biological_process	ubiquitin-dependent protein catabolic process
N	0006513	biological_process	protein monoubiquitination
N	0008013	molecular_function	beta-catenin binding
N	0016567	biological_process	protein ubiquitination
N	0019005	cellular_component	SCF ubiquitin ligase complex
N	0019904	molecular_function	protein domain specific binding
N	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
N	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
N	0031519	cellular_component	PcG protein complex
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0051457	biological_process	maintenance of protein location in nucleus
N	0070936	biological_process	protein K48-linked ubiquitination
N	0097602	molecular_function	cullin family protein binding
N	0140677	molecular_function	molecular function activator activity
N	0160072	molecular_function	ubiquitin ligase complex scaffold activity
N	1990444	molecular_function	F-box domain binding
N	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
N	1990757	molecular_function	ubiquitin ligase activator activity
P	0000209	biological_process	protein polyubiquitination
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005813	cellular_component	centrosome
P	0005829	cellular_component	cytosol
P	0006338	biological_process	chromatin remodeling
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0006513	biological_process	protein monoubiquitination
P	0008013	molecular_function	beta-catenin binding
P	0016567	biological_process	protein ubiquitination
P	0019005	cellular_component	SCF ubiquitin ligase complex
P	0019904	molecular_function	protein domain specific binding
P	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
P	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
P	0031519	cellular_component	PcG protein complex
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0051457	biological_process	maintenance of protein location in nucleus
P	0070936	biological_process	protein K48-linked ubiquitination
P	0097602	molecular_function	cullin family protein binding
P	0140677	molecular_function	molecular function activator activity
P	0160072	molecular_function	ubiquitin ligase complex scaffold activity
P	1990444	molecular_function	F-box domain binding
P	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
P	1990757	molecular_function	ubiquitin ligase activator activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	200
Details	Repeat: {"description":"LRR 1","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	216
Details	Repeat: {"description":"LRR 2","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	192
Details	Repeat: {"description":"LRR 3","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	176
Details	Repeat: {"description":"LRR 4","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	208
Details	Repeat: {"description":"LRR 5","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	176
Details	Repeat: {"description":"LRR 6","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	168
Details	Repeat: {"description":"LRR 7","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	176
Details	Repeat: {"description":"LRR 8","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	152
Details	Repeat: {"description":"LRR 9","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	168
Details	Repeat: {"description":"LRR 10","evidences":[{"source":"PubMed","id":"11099048","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	16
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)