1F93
CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THE DIMERIZATION DOMAIN OF HNF-1 ALPHA AND THE COACTIVATOR DCOH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003713 | molecular_function | transcription coactivator activity |
| A | 0004505 | molecular_function | phenylalanine 4-monooxygenase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006559 | biological_process | L-phenylalanine catabolic process |
| A | 0006571 | biological_process | L-tyrosine biosynthetic process |
| A | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| A | 0008124 | molecular_function | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| A | 0008150 | biological_process | biological_process |
| A | 0009072 | biological_process | aromatic amino acid metabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043393 | biological_process | regulation of protein binding |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0003713 | molecular_function | transcription coactivator activity |
| B | 0004505 | molecular_function | phenylalanine 4-monooxygenase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006559 | biological_process | L-phenylalanine catabolic process |
| B | 0006571 | biological_process | L-tyrosine biosynthetic process |
| B | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| B | 0008124 | molecular_function | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| B | 0008150 | biological_process | biological_process |
| B | 0009072 | biological_process | aromatic amino acid metabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043393 | biological_process | regulation of protein binding |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| C | 0003713 | molecular_function | transcription coactivator activity |
| C | 0004505 | molecular_function | phenylalanine 4-monooxygenase activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006559 | biological_process | L-phenylalanine catabolic process |
| C | 0006571 | biological_process | L-tyrosine biosynthetic process |
| C | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| C | 0008124 | molecular_function | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| C | 0008150 | biological_process | biological_process |
| C | 0009072 | biological_process | aromatic amino acid metabolic process |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0043393 | biological_process | regulation of protein binding |
| C | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| D | 0003713 | molecular_function | transcription coactivator activity |
| D | 0004505 | molecular_function | phenylalanine 4-monooxygenase activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006559 | biological_process | L-phenylalanine catabolic process |
| D | 0006571 | biological_process | L-tyrosine biosynthetic process |
| D | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| D | 0008124 | molecular_function | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| D | 0008150 | biological_process | biological_process |
| D | 0009072 | biological_process | aromatic amino acid metabolic process |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0043393 | biological_process | regulation of protein binding |
| D | 0045893 | biological_process | positive regulation of DNA-templated transcription |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"8444860","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 30 |
| Details | Region: {"description":"Dimerization"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dco |
| Chain | Residue | Details |
| A | HIS80 | |
| A | HIS62 | |
| A | HIS63 | |
| A | ASP89 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dco |
| Chain | Residue | Details |
| B | HIS80 | |
| B | HIS62 | |
| B | HIS63 | |
| B | ASP89 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dco |
| Chain | Residue | Details |
| C | HIS80 | |
| C | HIS62 | |
| C | HIS63 | |
| C | ASP89 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dco |
| Chain | Residue | Details |
| D | HIS80 | |
| D | HIS62 | |
| D | HIS63 | |
| D | ASP89 |
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 73 |
| Chain | Residue | Details |
| A | TRP66 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
| A | TYR70 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | ASN71 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | ARG88 | electrostatic stabiliser, hydrogen bond donor |
| A | ASP89 | electrostatic stabiliser, hydrogen bond donor |
| A | GLU97 | electrostatic stabiliser, hydrogen bond acceptor |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 73 |
| Chain | Residue | Details |
| B | TRP66 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
| B | TYR70 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | ASN71 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| B | ARG88 | electrostatic stabiliser, hydrogen bond donor |
| B | ASP89 | electrostatic stabiliser, hydrogen bond donor |
| B | GLU97 | electrostatic stabiliser, hydrogen bond acceptor |
| site_id | MCSA3 |
| Number of Residues | 6 |
| Details | M-CSA 73 |
| Chain | Residue | Details |
| C | TRP66 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
| C | TYR70 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| C | ASN71 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| C | ARG88 | electrostatic stabiliser, hydrogen bond donor |
| C | ASP89 | electrostatic stabiliser, hydrogen bond donor |
| C | GLU97 | electrostatic stabiliser, hydrogen bond acceptor |
| site_id | MCSA4 |
| Number of Residues | 6 |
| Details | M-CSA 73 |
| Chain | Residue | Details |
| D | TRP66 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
| D | TYR70 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| D | ASN71 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| D | ARG88 | electrostatic stabiliser, hydrogen bond donor |
| D | ASP89 | electrostatic stabiliser, hydrogen bond donor |
| D | GLU97 | electrostatic stabiliser, hydrogen bond acceptor |
