1F93
CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THE DIMERIZATION DOMAIN OF HNF-1 ALPHA AND THE COACTIVATOR DCOH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003713 | molecular_function | transcription coactivator activity |
| A | 0004505 | molecular_function | phenylalanine 4-monooxygenase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006558 | biological_process | L-phenylalanine metabolic process |
| A | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| A | 0008124 | molecular_function | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| A | 0008150 | biological_process | biological_process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019293 | biological_process | tyrosine biosynthetic process, by oxidation of phenylalanine |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043393 | biological_process | regulation of protein binding |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0003713 | molecular_function | transcription coactivator activity |
| B | 0004505 | molecular_function | phenylalanine 4-monooxygenase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006558 | biological_process | L-phenylalanine metabolic process |
| B | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| B | 0008124 | molecular_function | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| B | 0008150 | biological_process | biological_process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019293 | biological_process | tyrosine biosynthetic process, by oxidation of phenylalanine |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043393 | biological_process | regulation of protein binding |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| C | 0003713 | molecular_function | transcription coactivator activity |
| C | 0004505 | molecular_function | phenylalanine 4-monooxygenase activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006558 | biological_process | L-phenylalanine metabolic process |
| C | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| C | 0008124 | molecular_function | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| C | 0008150 | biological_process | biological_process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0019293 | biological_process | tyrosine biosynthetic process, by oxidation of phenylalanine |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0043393 | biological_process | regulation of protein binding |
| C | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| D | 0003713 | molecular_function | transcription coactivator activity |
| D | 0004505 | molecular_function | phenylalanine 4-monooxygenase activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006558 | biological_process | L-phenylalanine metabolic process |
| D | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| D | 0008124 | molecular_function | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| D | 0008150 | biological_process | biological_process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0019293 | biological_process | tyrosine biosynthetic process, by oxidation of phenylalanine |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0043393 | biological_process | regulation of protein binding |
| D | 0045893 | biological_process | positive regulation of DNA-templated transcription |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP61 | |
| A | SER78 | |
| B | ASP61 | |
| B | SER78 | |
| C | ASP61 | |
| C | SER78 | |
| D | ASP61 | |
| D | SER78 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:8444860 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 | |
| C | ALA2 | |
| D | ALA2 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dco |
| Chain | Residue | Details |
| A | HIS80 | |
| A | HIS62 | |
| A | HIS63 | |
| A | ASP89 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dco |
| Chain | Residue | Details |
| B | HIS80 | |
| B | HIS62 | |
| B | HIS63 | |
| B | ASP89 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dco |
| Chain | Residue | Details |
| C | HIS80 | |
| C | HIS62 | |
| C | HIS63 | |
| C | ASP89 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dco |
| Chain | Residue | Details |
| D | HIS80 | |
| D | HIS62 | |
| D | HIS63 | |
| D | ASP89 |
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 73 |
| Chain | Residue | Details |
| A | GLU58 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
| A | HIS62 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | HIS63 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | HIS80 | electrostatic stabiliser, hydrogen bond donor |
| A | GLU81 | electrostatic stabiliser, hydrogen bond donor |
| A | ASP89 | electrostatic stabiliser, hydrogen bond acceptor |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 73 |
| Chain | Residue | Details |
| B | GLU58 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
| B | HIS62 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | HIS63 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| B | HIS80 | electrostatic stabiliser, hydrogen bond donor |
| B | GLU81 | electrostatic stabiliser, hydrogen bond donor |
| B | ASP89 | electrostatic stabiliser, hydrogen bond acceptor |
| site_id | MCSA3 |
| Number of Residues | 6 |
| Details | M-CSA 73 |
| Chain | Residue | Details |
| C | GLU58 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
| C | HIS62 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| C | HIS63 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| C | HIS80 | electrostatic stabiliser, hydrogen bond donor |
| C | GLU81 | electrostatic stabiliser, hydrogen bond donor |
| C | ASP89 | electrostatic stabiliser, hydrogen bond acceptor |
| site_id | MCSA4 |
| Number of Residues | 6 |
| Details | M-CSA 73 |
| Chain | Residue | Details |
| D | GLU58 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
| D | HIS62 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| D | HIS63 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| D | HIS80 | electrostatic stabiliser, hydrogen bond donor |
| D | GLU81 | electrostatic stabiliser, hydrogen bond donor |
| D | ASP89 | electrostatic stabiliser, hydrogen bond acceptor |
