Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1F93

CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THE DIMERIZATION DOMAIN OF HNF-1 ALPHA AND THE COACTIVATOR DCOH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003713	molecular_function	transcription coactivator activity
A	0004505	molecular_function	phenylalanine 4-monooxygenase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006558	biological_process	L-phenylalanine metabolic process
A	0006729	biological_process	tetrahydrobiopterin biosynthetic process
A	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
A	0008150	biological_process	biological_process
A	0009072	biological_process	aromatic amino acid metabolic process
A	0016829	molecular_function	lyase activity
A	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
A	0042802	molecular_function	identical protein binding
A	0043393	biological_process	regulation of protein binding
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	1902221	biological_process	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
B	0003713	molecular_function	transcription coactivator activity
B	0004505	molecular_function	phenylalanine 4-monooxygenase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006558	biological_process	L-phenylalanine metabolic process
B	0006729	biological_process	tetrahydrobiopterin biosynthetic process
B	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
B	0008150	biological_process	biological_process
B	0009072	biological_process	aromatic amino acid metabolic process
B	0016829	molecular_function	lyase activity
B	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
B	0042802	molecular_function	identical protein binding
B	0043393	biological_process	regulation of protein binding
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	1902221	biological_process	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
C	0003713	molecular_function	transcription coactivator activity
C	0004505	molecular_function	phenylalanine 4-monooxygenase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006558	biological_process	L-phenylalanine metabolic process
C	0006729	biological_process	tetrahydrobiopterin biosynthetic process
C	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
C	0008150	biological_process	biological_process
C	0009072	biological_process	aromatic amino acid metabolic process
C	0016829	molecular_function	lyase activity
C	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
C	0042802	molecular_function	identical protein binding
C	0043393	biological_process	regulation of protein binding
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	1902221	biological_process	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
D	0003713	molecular_function	transcription coactivator activity
D	0004505	molecular_function	phenylalanine 4-monooxygenase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006558	biological_process	L-phenylalanine metabolic process
D	0006729	biological_process	tetrahydrobiopterin biosynthetic process
D	0008124	molecular_function	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
D	0008150	biological_process	biological_process
D	0009072	biological_process	aromatic amino acid metabolic process
D	0016829	molecular_function	lyase activity
D	0019293	biological_process	tyrosine biosynthetic process, by oxidation of phenylalanine
D	0042802	molecular_function	identical protein binding
D	0043393	biological_process	regulation of protein binding
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	1902221	biological_process	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"8444860","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	30
Details	Region: {"description":"Dimerization"}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1dco

Chain	Residue	Details
A	HIS80
A	HIS62
A	HIS63
A	ASP89

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1dco

Chain	Residue	Details
B	HIS80
B	HIS62
B	HIS63
B	ASP89

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1dco

Chain	Residue	Details
C	HIS80
C	HIS62
C	HIS63
C	ASP89

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1dco

Chain	Residue	Details
D	HIS80
D	HIS62
D	HIS63
D	ASP89

site_id	MCSA1
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
A	TRP66	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
A	TYR70	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	ASN71	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
A	ARG88	electrostatic stabiliser, hydrogen bond donor
A	ASP89	electrostatic stabiliser, hydrogen bond donor
A	GLU97	electrostatic stabiliser, hydrogen bond acceptor

site_id	MCSA2
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
B	TRP66	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
B	TYR70	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
B	ASN71	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
B	ARG88	electrostatic stabiliser, hydrogen bond donor
B	ASP89	electrostatic stabiliser, hydrogen bond donor
B	GLU97	electrostatic stabiliser, hydrogen bond acceptor

site_id	MCSA3
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
C	TRP66	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
C	TYR70	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
C	ASN71	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
C	ARG88	electrostatic stabiliser, hydrogen bond donor
C	ASP89	electrostatic stabiliser, hydrogen bond donor
C	GLU97	electrostatic stabiliser, hydrogen bond acceptor

site_id	MCSA4
Number of Residues	6
Details	M-CSA 73

Chain	Residue	Details
D	TRP66	electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor
D	TYR70	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
D	ASN71	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
D	ARG88	electrostatic stabiliser, hydrogen bond donor
D	ASP89	electrostatic stabiliser, hydrogen bond donor
D	GLU97	electrostatic stabiliser, hydrogen bond acceptor

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)