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1A4R

G12V MUTANT OF HUMAN PLACENTAL CDC42 GTPASE IN THE GDP FORM

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000322cellular_componentstorage vacuole
A0002040biological_processsprouting angiogenesis
A0003015biological_processheart process
A0003161biological_processcardiac conduction system development
A0003253biological_processcardiac neural crest cell migration involved in outflow tract morphogenesis
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005813cellular_componentcentrosome
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0005925cellular_componentfocal adhesion
A0006897biological_processendocytosis
A0006911biological_processphagocytosis, engulfment
A0007015biological_processactin filament organization
A0007030biological_processGolgi organization
A0007088biological_processregulation of mitotic nuclear division
A0007097biological_processnuclear migration
A0007163biological_processestablishment or maintenance of cell polarity
A0007229biological_processintegrin-mediated signaling pathway
A0007264biological_processsmall GTPase-mediated signal transduction
A0007399biological_processnervous system development
A0008104biological_processprotein localization
A0009653biological_processanatomical structure morphogenesis
A0010591biological_processregulation of lamellipodium assembly
A0010592biological_processpositive regulation of lamellipodium assembly
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0017119cellular_componentGolgi transport complex
A0019901molecular_functionprotein kinase binding
A0021762biological_processsubstantia nigra development
A0030010biological_processestablishment of cell polarity
A0030036biological_processactin cytoskeleton organization
A0030141cellular_componentsecretory granule
A0030154biological_processcell differentiation
A0030175cellular_componentfilopodium
A0030225biological_processmacrophage differentiation
A0030307biological_processpositive regulation of cell growth
A0030335biological_processpositive regulation of cell migration
A0030425cellular_componentdendrite
A0030496cellular_componentmidbody
A0030742molecular_functionGTP-dependent protein binding
A0031252cellular_componentcell leading edge
A0031256cellular_componentleading edge membrane
A0031274biological_processpositive regulation of pseudopodium assembly
A0031333biological_processnegative regulation of protein-containing complex assembly
A0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
A0031996molecular_functionthioesterase binding
A0032427molecular_functionGBD domain binding
A0032467biological_processpositive regulation of cytokinesis
A0032488biological_processCdc42 protein signal transduction
A0032956biological_processregulation of actin cytoskeleton organization
A0032991cellular_componentprotein-containing complex
A0034191molecular_functionapolipoprotein A-I receptor binding
A0034329biological_processcell junction assembly
A0034332biological_processadherens junction organization
A0035050biological_processembryonic heart tube development
A0035088biological_processestablishment or maintenance of apical/basal cell polarity
A0036336biological_processdendritic cell migration
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0038189biological_processneuropilin signaling pathway
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043197cellular_componentdendritic spine
A0043410biological_processpositive regulation of MAPK cascade
A0043525biological_processpositive regulation of neuron apoptotic process
A0044788biological_processmodulation by host of viral process
A0045177cellular_componentapical part of cell
A0045198biological_processestablishment of epithelial cell apical/basal polarity
A0045335cellular_componentphagocytic vesicle
A0045740biological_processpositive regulation of DNA replication
A0046330biological_processpositive regulation of JNK cascade
A0046847biological_processfilopodium assembly
A0048549biological_processpositive regulation of pinocytosis
A0048664biological_processneuron fate determination
A0051130biological_processpositive regulation of cellular component organization
A0051233cellular_componentspindle midzone
A0051489biological_processregulation of filopodium assembly
A0051491biological_processpositive regulation of filopodium assembly
A0051492biological_processregulation of stress fiber assembly
A0051496biological_processpositive regulation of stress fiber assembly
A0051647biological_processnucleus localization
A0051649biological_processestablishment of localization in cell
A0051683biological_processestablishment of Golgi localization
A0051835biological_processpositive regulation of synapse structural plasticity
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051988biological_processregulation of attachment of spindle microtubules to kinetochore
A0060047biological_processheart contraction
A0060071biological_processWnt signaling pathway, planar cell polarity pathway
A0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
A0060661biological_processsubmandibular salivary gland formation
A0060997biological_processdendritic spine morphogenesis
A0061630molecular_functionubiquitin protein ligase activity
A0070062cellular_componentextracellular exosome
A0071346biological_processcellular response to type II interferon
A0071944cellular_componentcell periphery
A0072384biological_processorganelle transport along microtubule
A0072686cellular_componentmitotic spindle
A0086101biological_processendothelin receptor signaling pathway involved in heart process
A0090135biological_processactin filament branching
A0090316biological_processpositive regulation of intracellular protein transport
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099159biological_processregulation of modification of postsynaptic structure
A0099175biological_processregulation of postsynapse organization
A1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
A1990606molecular_functionmembrane scission GTPase motor activity
B0000139cellular_componentGolgi membrane
B0000322cellular_componentstorage vacuole
B0002040biological_processsprouting angiogenesis
B0003015biological_processheart process
B0003161biological_processcardiac conduction system development
B0003253biological_processcardiac neural crest cell migration involved in outflow tract morphogenesis
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005789cellular_componentendoplasmic reticulum membrane
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0005925cellular_componentfocal adhesion
B0006897biological_processendocytosis
B0006911biological_processphagocytosis, engulfment
B0007015biological_processactin filament organization
B0007030biological_processGolgi organization
B0007088biological_processregulation of mitotic nuclear division
B0007097biological_processnuclear migration
B0007163biological_processestablishment or maintenance of cell polarity
B0007229biological_processintegrin-mediated signaling pathway
B0007264biological_processsmall GTPase-mediated signal transduction
B0007399biological_processnervous system development
B0008104biological_processprotein localization
B0009653biological_processanatomical structure morphogenesis
B0010591biological_processregulation of lamellipodium assembly
B0010592biological_processpositive regulation of lamellipodium assembly
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0017119cellular_componentGolgi transport complex
B0019901molecular_functionprotein kinase binding
B0021762biological_processsubstantia nigra development
B0030010biological_processestablishment of cell polarity
B0030036biological_processactin cytoskeleton organization
B0030141cellular_componentsecretory granule
B0030154biological_processcell differentiation
B0030175cellular_componentfilopodium
B0030225biological_processmacrophage differentiation
B0030307biological_processpositive regulation of cell growth
B0030335biological_processpositive regulation of cell migration
B0030425cellular_componentdendrite
B0030496cellular_componentmidbody
B0030742molecular_functionGTP-dependent protein binding
B0031252cellular_componentcell leading edge
B0031256cellular_componentleading edge membrane
B0031274biological_processpositive regulation of pseudopodium assembly
B0031333biological_processnegative regulation of protein-containing complex assembly
B0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
B0031996molecular_functionthioesterase binding
B0032427molecular_functionGBD domain binding
B0032467biological_processpositive regulation of cytokinesis
B0032488biological_processCdc42 protein signal transduction
B0032956biological_processregulation of actin cytoskeleton organization
B0032991cellular_componentprotein-containing complex
B0034191molecular_functionapolipoprotein A-I receptor binding
B0034329biological_processcell junction assembly
B0034332biological_processadherens junction organization
B0035050biological_processembryonic heart tube development
B0035088biological_processestablishment or maintenance of apical/basal cell polarity
B0036336biological_processdendritic cell migration
B0036464cellular_componentcytoplasmic ribonucleoprotein granule
B0038189biological_processneuropilin signaling pathway
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0043410biological_processpositive regulation of MAPK cascade
B0043525biological_processpositive regulation of neuron apoptotic process
B0044788biological_processmodulation by host of viral process
B0045177cellular_componentapical part of cell
B0045198biological_processestablishment of epithelial cell apical/basal polarity
B0045335cellular_componentphagocytic vesicle
B0045740biological_processpositive regulation of DNA replication
B0046330biological_processpositive regulation of JNK cascade
B0046847biological_processfilopodium assembly
B0048549biological_processpositive regulation of pinocytosis
B0048664biological_processneuron fate determination
B0051130biological_processpositive regulation of cellular component organization
B0051233cellular_componentspindle midzone
B0051489biological_processregulation of filopodium assembly
B0051491biological_processpositive regulation of filopodium assembly
B0051492biological_processregulation of stress fiber assembly
B0051496biological_processpositive regulation of stress fiber assembly
B0051647biological_processnucleus localization
B0051649biological_processestablishment of localization in cell
B0051683biological_processestablishment of Golgi localization
B0051835biological_processpositive regulation of synapse structural plasticity
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051988biological_processregulation of attachment of spindle microtubules to kinetochore
B0060047biological_processheart contraction
B0060071biological_processWnt signaling pathway, planar cell polarity pathway
B0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
B0060661biological_processsubmandibular salivary gland formation
B0060997biological_processdendritic spine morphogenesis
B0061630molecular_functionubiquitin protein ligase activity
B0070062cellular_componentextracellular exosome
B0071346biological_processcellular response to type II interferon
B0071944cellular_componentcell periphery
B0072384biological_processorganelle transport along microtubule
B0072686cellular_componentmitotic spindle
B0086101biological_processendothelin receptor signaling pathway involved in heart process
B0090135biological_processactin filament branching
B0090316biological_processpositive regulation of intracellular protein transport
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099159biological_processregulation of modification of postsynaptic structure
B0099175biological_processregulation of postsynapse organization
B1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
B1990606molecular_functionmembrane scission GTPase motor activity
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG A 199
ChainResidue
ATHR17
AASP57
AGDP200
AHOH1000
AHOH1001
AHOH1002
AHOH1003

site_idAC2
Number of Residues20
DetailsBINDING SITE FOR RESIDUE GDP A 200
ChainResidue
AVAL14
AGLY15
ALYS16
ATHR17
ACYS18
AGLN116
AASP118
ALEU119
AARG147
ASER158
AALA159
ALEU160
AMG199
AHOH1001
AHOH1002
AHOH1006
AHOH1013
AHOH1045
AASP11
AALA13

site_idAC3
Number of Residues14
DetailsBINDING SITE FOR RESIDUE GNH B 400
ChainResidue
BVAL212
BALA213
BGLY215
BLYS216
BTHR217
BCYS218
BPHE228
BGLN316
BASP318
BLEU319
BARG347
BSER358
BALA359
BLEU360

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING:
ChainResidueDetails
AGLY10
ATHR115
BGLY210
BTHR315

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASP57
BASP257

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538, ECO:0000269|PubMed:20622875
ChainResidueDetails
ATYR32
BTYR232

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
ATHR35
BTHR235

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by SRC => ECO:0000269|PubMed:14506284
ChainResidueDetails
ATYR64
BTYR264

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Cysteine methyl ester => ECO:0000269|PubMed:10676816, ECO:0007744|PDB:1DOA
ChainResidueDetails
ACYS188
BCYS388

site_idSWS_FT_FI7
Number of Residues2
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000269|PubMed:10676816, ECO:0007744|PDB:1DOA
ChainResidueDetails
ACYS188
BCYS388

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
ATYR32
BTYR232

site_idSWS_FT_FI9
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
ATHR35
BTHR235

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AGLN61

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
BGLN261

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
BALA213

227111

PDB entries from 2024-11-06

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