7BQV
Cereblon in complex with SALL4 and (S)-5-hydroxythalidomide
Experimental procedure
Experimental method | SINGLE WAVELENGTH |
Source type | SYNCHROTRON |
Source details | PHOTON FACTORY BEAMLINE AR-NE3A |
Synchrotron site | Photon Factory |
Beamline | AR-NE3A |
Temperature [K] | 95 |
Detector technology | PIXEL |
Collection date | 2019-10-31 |
Detector | DECTRIS PILATUS 2M-F |
Wavelength(s) | 1.0000 |
Spacegroup name | C 2 2 21 |
Unit cell lengths | 83.621, 93.895, 43.682 |
Unit cell angles | 90.00, 90.00, 90.00 |
Refinement procedure
Resolution | 35.794 - 1.800 |
R-factor | 0.1983 |
Rwork | 0.197 |
R-free | 0.22340 |
Structure solution method | MOLECULAR REPLACEMENT |
Starting model (for MR) | 7bqu |
RMSD bond length | 0.006 |
RMSD bond angle | 0.858 |
Data reduction software | XDS |
Data scaling software | Aimless |
Phasing software | PHASER (Ver 1.15.1_3469) |
Refinement software | PHENIX (Ver 1.15.1_3469) |
Data quality characteristics
Overall | Outer shell | |
Low resolution limit [Å] | 46.950 | 1.840 |
High resolution limit [Å] | 1.800 | 1.800 |
Rmeas | 0.088 | 1.375 |
Rpim | 0.024 | 0.373 |
Number of reflections | 16362 | 957 |
<I/σ(I)> | 21 | 2.3 |
Completeness [%] | 100.0 | 100 |
Redundancy | 13.1 | 13.3 |
CC(1/2) | 1.000 | 0.832 |
Crystallization Conditions
crystal ID | method | pH | temperature | details |
1 | VAPOR DIFFUSION, SITTING DROP | 293 | 22% PEG 4000, 0.1 M MES (pH 6.0), 0.2 M lithium sulfate |