7BQV

Cereblon in complex with SALL4 and (S)-5-hydroxythalidomide

Summary for 7BQV

Entry DOI	10.2210/pdb7bqv/pdb
Descriptor	Protein cereblon, Sal-like protein 4, 2-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-5-oxidanyl-isoindole-1,3-dione, ... (6 entities in total)
Functional Keywords	zinc finger, e3 ubiquitin ligase, complex, thalidomide, metal binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	15606.54
Authors	Furihata, H.,Miyauchi, Y.,Asano, A.,Tanokura, M.,Miyakawa, T. (deposition date: 2020-03-25, release date: 2020-08-26, Last modification date: 2023-11-29)
Primary citation	Furihata, H.,Yamanaka, S.,Honda, T.,Miyauchi, Y.,Asano, A.,Shibata, N.,Tanokura, M.,Sawasaki, T.,Miyakawa, T. Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide. Nat Commun, 11:4578-4578, 2020 Cited by PubMed: 32929090 DOI: 10.1038/s41467-020-18488-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation