7BQV
Cereblon in complex with SALL4 and (S)-5-hydroxythalidomide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein cereblon | polymer | 109 | 12203.1 | 1 | UniProt (Q96SW2) Pfam (PF03226) | Homo sapiens (Human) | |
| 2 | B (B) | Sal-like protein 4 | polymer | 24 | 2806.3 | 1 | UniProt (Q9UJQ4) Pfam (PF00096) | Homo sapiens (Human) | Zinc finger protein 797,Zinc finger protein SALL4 |
| 3 | C (A) | 2-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-5-oxidanyl-isoindole-1,3-dione | non-polymer | 274.2 | 1 | Chemie (F4U) | |||
| 4 | D, F (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | E, G (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
A: 318 - 426 (UniProt: Q96SW2)
B: 410 - 432 (UniProt: Q9UJQ4)
| PDB | External Database | Details |
|---|---|---|
| Ser 366 | Cys 366 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 409 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 15009.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 597.2 | |
| All* | Total formula weight | 15606.5 |
