7BQU
Cereblon in complex with SALL4 and (S)-thalidomide
Summary for 7BQU
| Entry DOI | 10.2210/pdb7bqu/pdb |
| Descriptor | Protein cereblon, Sal-like protein 4, S-Thalidomide, ... (5 entities in total) |
| Functional Keywords | zinc finger, e3 ubiquitin ligase, complex, thalidomide, metal binding protein |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 16134.24 |
| Authors | Furihata, H.,Miyauchi, Y.,Asano, A.,Tanokura, M.,Miyakawa, T. (deposition date: 2020-03-25, release date: 2020-08-26, Last modification date: 2023-11-29) |
| Primary citation | Furihata, H.,Yamanaka, S.,Honda, T.,Miyauchi, Y.,Asano, A.,Shibata, N.,Tanokura, M.,Sawasaki, T.,Miyakawa, T. Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide. Nat Commun, 11:4578-4578, 2020 Cited by PubMed: 32929090DOI: 10.1038/s41467-020-18488-4 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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