7BQU
Cereblon in complex with SALL4 and (S)-thalidomide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein cereblon | polymer | 114 | 12614.5 | 1 | UniProt (Q96SW2) Pfam (PF03226) | Homo sapiens (Human) | |
| 2 | B (B) | Sal-like protein 4 | polymer | 28 | 3130.7 | 1 | UniProt (Q9UJQ4) Pfam (PF00096) | Homo sapiens (Human) | Zinc finger protein 797,Zinc finger protein SALL4 |
| 3 | C (A) | S-Thalidomide | non-polymer | 258.2 | 1 | Chemie (EF2) | |||
| 4 | D, E (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
A: 318 - 426 (UniProt: Q96SW2)
B: 410 - 432 (UniProt: Q9UJQ4)
| PDB | External Database | Details |
|---|---|---|
| Gly 313 | - | expression tag |
| Pro 314 | - | expression tag |
| Leu 315 | - | expression tag |
| Gly 316 | - | expression tag |
| Ser 317 | - | expression tag |
| Ser 366 | Cys 366 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 405 | - | expression tag |
| Pro 406 | - | expression tag |
| Leu 407 | - | expression tag |
| Gly 408 | - | expression tag |
| Ser 409 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 15745.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 389.0 | |
| All* | Total formula weight | 16134.2 |
