6NHA
Crystal structure of SYNT001, a human FcRn blocking monoclonal antibody
Experimental procedure
Experimental method | SINGLE WAVELENGTH |
Source type | SYNCHROTRON |
Source details | APS BEAMLINE 24-ID-E |
Synchrotron site | APS |
Beamline | 24-ID-E |
Temperature [K] | 100 |
Detector technology | CCD |
Collection date | 2016-11-09 |
Detector | ADSC QUANTUM 315 |
Wavelength(s) | 0.979 |
Spacegroup name | P 21 21 21 |
Unit cell lengths | 64.830, 77.664, 215.605 |
Unit cell angles | 90.00, 90.00, 90.00 |
Refinement procedure
Data quality characteristics
Overall | Inner shell | Outer shell | |
Low resolution limit [Å] | 200.000 | 200.000 | 2.540 |
High resolution limit [Å] | 2.380 | 6.790 | 2.500 |
Rmerge | 0.107 | 0.043 | 1.816 |
Rmeas | 0.116 | 0.046 | 1.981 |
Rpim | 0.044 | 0.018 | 0.777 |
Number of reflections | 41525 | 2153 | 1656 |
<I/σ(I)> | 7.3 | ||
Completeness [%] | 92.5 | 99.4 | 85.5 |
Redundancy | 6.4 | 6.5 | 6 |
CC(1/2) | 0.999 | 0.447 |
Crystallization Conditions
crystal ID | method | pH | temperature | details |
1 | VAPOR DIFFUSION, SITTING DROP | 9.5 | 277.15 | 0.1M CHES pH 9.5 50% polyethylene glycol 200 |