6NHA

Crystal structure of SYNT001, a human FcRn blocking monoclonal antibody

Summary for 6NHA

Entry DOI	10.2210/pdb6nha/pdb
Descriptor	IgG receptor FcRn large subunit p51, Beta-2-microglobulin, SYNT001-Fab light chain, ... (6 entities in total)
Functional Keywords	fcrn, b2m, circulating igg and igg immune complex, synt001, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	90404.19
Authors	Blumberg, R.S.,Cheung, J.,Mahmood, A.,Gandhi, A.K. (deposition date: 2018-12-21, release date: 2019-12-25, Last modification date: 2023-10-11)
Primary citation	Blumberg, L.J.,Humphries, J.E.,Jones, S.D.,Pearce, L.B.,Holgate, R.,Hearn, A.,Cheung, J.,Mahmood, A.,Del Tito, B.,Graydon, J.S.,Stolz, L.E.,Bitonti, A.,Purohit, S.,de Graaf, D.,Kacena, K.,Andersen, J.T.,Christianson, G.J.,Roopenian, D.C.,Hubbard, J.J.,Gandhi, A.K.,Lasseter, K.,Pyzik, M.,Blumberg, R.S. Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses. Sci Adv, 5:eaax9586-eaax9586, 2019 Cited by PubMed: 31897428 DOI: 10.1126/sciadv.aax9586 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.381 Å)

Structure validation