6NHA
Crystal structure of SYNT001, a human FcRn blocking monoclonal antibody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | IgG receptor FcRn large subunit p51 | polymer | 279 | 31072.8 | 1 | UniProt (P55899) Pfam (PF00129) Pfam (PF07654) In PDB | Homo sapiens (Human) | FcRn,IgG Fc fragment receptor transporter alpha chain,Neonatal Fc receptor |
| 2 | B | Beta-2-microglobulin | polymer | 99 | 11748.2 | 1 | UniProt (P61769) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
| 3 | L | SYNT001-Fab light chain | polymer | 214 | 23445.9 | 1 | Homo sapiens (Human) | ||
| 4 | H | SYNT001-Fab heavy chain | polymer | 220 | 23515.4 | 1 | Homo sapiens (Human) | ||
| 5 | A, H | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID | non-polymer | 207.3 | 3 | Chemie (NHE) | |||
| 6 | water | water | 18.0 | 166 | Chemie (HOH) |
Sequence modifications
A: 1 - 273 (UniProt: P55899)
| PDB | External Database | Details |
|---|---|---|
| Ala 102 | Asn 125 | engineered mutation |
| Glu 274 | - | expression tag |
| Asn 275 | - | expression tag |
| Leu 276 | - | expression tag |
| Tyr 277 | - | expression tag |
| Phe 278 | - | expression tag |
| Gln 279 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 89782.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 621.9 | |
| All* | Total formula weight | 90404.2 |
